Nanotechnology Enabled Temporomandibular Joint(TMJ)Prosthesis

纳米技术颞下颌关节 (TMJ) 假体

• 批准号: 8199210
• 负责人: Raymond G. Thompson
• 金额: $ 43.5万
• 依托单位: VISTA ENGINEERING, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199210
• 关键词: Adhesions; Affect; American; Animal Model; Animals; Capital; Clinical; Clinical Pathways; Collaborations; Collection; Computer Analysis; Computer Simulation; Computers; Dental; Deposition; Deterioration; Devices; Diamond; Elements; Engineering; Family suidae; Health behavior; Human; Implant; Joint Prosthesis; Joints; Legal patent; Letters; Licensing; Life; Mandible; Masticatory muscles; Measurement; Medical; Metals; Modeling; Monitor; Nanotechnology; Osseointegration; Pathway interactions; Patients; Performance; Phase; Process; Production; Property; Prosthesis; Prosthesis Design; Prosthesis Failure; Replacement Arthroplasty; Route; Specific qualifier value; Stress; Structure; Surface; Surgical incisions; Technology; Temporomandibular Joint; Temporomandibular Joint Disorders; Test Result; Testing; Thick; Tissues; Translations; base; commercialization; design; implantable device; implantation; improved; meetings; minimally invasive; nanostructured; new technology; novel; prototype; research clinical testing; restoration; sample fixation; success; ultra-high molecular weight polyethylene

DESCRIPTION (provided by applicant): Temporomandibular Disorders (TMD) represent a collection of medical and dental conditions affecting the temporomandibular joint (TMJ) and/or the muscles of mastication, as well as contiguous tissue structures. For some patients with severe TMJ degeneration, a prosthetic replacement may be required. However, long-term success and functioning of current implant designs remains a serious problem due, in large part, to the deterioration of the implant and surrounding tissue resulting from wear debris. During Phase I of this project, the UAB and Vista Engineering team developed novel nanotechnology diamond coatings with enhanced adhesion and wear properties for articulation components in TMJ devices. This new technology will be used in the proposed Phase II to enable new total replacement TMJ prostheses of smaller size and longer life. The smaller sized prosthesis designs will enable minimally invasive clinical pathways targeted for a single-incision implantation. The new TMJ prostheses will be designed using finite element modeling and analysis to minimize the device size based on the use of nanostructured diamond on the articulating surfaces. The prototype designs will be manufactured and tested in a TMJ, mandibular wear simulator. Successful designs will be carried to clinical translation studies using a miniature pig animal model. Commercialization potential for the product will be developed through prosthesis design, prototype wear testing and clinical translation. Letters of support for this Phase II project have come from biomedical and venture capital companies in support of our commercialization plan. UAB and Vista Engineering have a strong track record of collaboration culminating in the licensing (to Vista Engineering) of a UAB patent involving this technology: "Process for Ultra Smooth Diamond Coating on Metals and Uses Thereof", Patent # 6,183,818. Our specific aims are as follows: Specific Aim 1: Optimize New Designs for Minimally Invasive TMJ Total Replacement Prosthesis by Computer Modeling and Analysis. Specific Aim 2: Manufacture Prototype Prostheses of Promising Minimally Invasive Designs. Specific Aim 3: Rank and Revise Computer-Optimized Designs Based on Test Results from Mandibular Wear Simulator Specific Aim 4: Conduct Clinical Translation Studies on Two Most Promising Designs PUBLIC HEALTH RELEVANCE: We propose the use of a nanotechnology approach, using nanostructured diamond for controlling interfaces between Temporomandibular Joint (TMJ) implants and the surrounding tissues, to improve the fixation, durability and osseointegration for long-term implant success. As many as 60,000 Americans could benefit from the nanostructured diamond-diamond components that will facilitate reductions in implant device size and enable a clinically less- invasive route to joint restoration. We also propose a clear pathway for commercialization of the nanotechnology enabled TMJ prosthesis.

描述（由申请人提供）：颞下颌疾病（TMD）代表影响颞下颌关节（TMJ）和/或咀嚼肌肉以及连续组织结构的医疗和牙科疾病的集合。对于某些严重TMJ变性的患者，可能需要修复假体。但是，由于磨损碎屑导致的植入物和周围组织的恶化，当前植入物设计的长期成功和当前植入物设计的功能仍然是一个严重的问题。在该项目的第一阶段，UAB和Vista工程团队开发了新型的纳米技术钻石涂料，具有增强的粘附和磨损特性，可用于TMJ设备中的发音组件。这项新技术将在拟议的II期中使用，以实现新的总替代TMJ假体，其尺寸较小，寿命更长。规模较小的假体设计将使最小的侵入性临床途径针对单个植入。新的TMJ假体将使用有限元建模和分析设计，以最大程度地降低设备大小，以在表达表面上使用纳米结构的钻石。原型设计将在TMJ，下颌磨损模拟器中制造和测试。成功的设计将使用微型猪动物模型进行临床翻译研究。该产品的商业化潜力将通过假体设计，原型磨损测试和临床翻译开发。对这一第二阶段项目的支持信来自生物医学和风险投资公司，以支持我们的商业化计划。 UAB和VISTA工程具有很强的协作记录，最终是UAB专利的许可（Vista Engineering），涉及这项技术：“用于金属上的超光滑钻石涂层的过程”，专利＃6,183,818。我们的具体目的如下：特定目的1：通过计算机建模和分析优化最小侵入性TMJ TMJ总替换假体的新设计。特定目的2：制造有希望的微创设计的原型假体。特定目的3：基于下颌磨损模拟器特定目标的测试结果的等级和修改计算机优化的设计4：对两个最有前途的设计进行临床翻译研究 公共卫生相关性：我们建议使用纳米技术方法，使用纳米结构的钻石来控制颞下颌关节（TMJ）植入物与周围组织之间的接口，以改善长期植入物成功的固定性，耐用性和渗透性。多达60,000名美国人可以从纳米结构的Diamond-Diamond组件中受益，这些组件将有助于减少植入物设备的大小，并使临床上较低的联合恢复途径降低。我们还提出了纳米技术的商业化启用TMJ假体的明确途径。