THE MANHATTAN HIV BRAIN BANK

曼哈顿艾滋病毒脑库

• 批准号: 7718106
• 负责人: Susan Morgello
• 金额: $ 15.21万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718106
• 关键词: AIDS neuropathy; Autopsy; Brain; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Disease; Dissection; Funding; Grant; HIV; Hepatic; Institution; Investigation; Liquid substance; Liver diseases; Longitudinal Studies; Morbidity - disease rate; Neurologic; Neurologic Dysfunctions; Neuropsychology; Organ Donations; Pathogenesis; Pathologic; Pathology; Patients; Qualifying; Range; Recruitment Activity; Research; Research Personnel; Resources; Risk; Site; Source; Testing; Tissues; Transplantation; United States National Institutes of Health; cohort; defined contribution; health disparity; human tissue; mortality; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Manhattan HIV Brain Bank (MHBB) is a resource that provides well-characterized human tissues and fluids for NeuroAIDS research. As part of the National NeuroAIDS Tissue Consortium (NNTC), it distributes materials to a wide range of investigators, and has begun a program of observational investigation. In the next 5 year period, we will continue and increase the provision of information, tissues, and fluids from HIV-infected patients to qualified researchers investigating HIV pathogenesis, and continue to recruit HIV-infected patients into an organ donation program preceded by a longitudinal neurologic, neuropsychologic, and psychiatric study. Both individually and with other NNTC sites, we will examine traditional clinico-pathologic correlations of premortem function with postmortem pathology, and to examine the longitudinal progression of neuroAIDS disorders. We will additionally create an organ donation program in an HIV-negative control cohort, that will serve as a source of virologic control materials and also aid in the dissection of hepatic influences on NeuroAIDS disorders. Specifically, a group of pre-transplant liver disease patients with well-defined risk of mortality will be recruited to an organ donation program and longitudinal study with the NNTC battery of tests. There will be a continued focus on co-morbidities and health disparities in HIV-related CNS and PNS disorders, particularly in defining contributions of liver disease, substance disorders, and HIV on cognitive and neurologic dysfunction.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 曼哈顿艾滋病毒脑库 (MHBB) 是一个为神经艾滋病研究提供特征良好的人体组织和液体的资源。 作为国家神经艾滋病组织联盟 (NNTC) 的一部分，它向广泛的研究人员分发材料，并已开始一项观察调查计划。 在接下来的5年中，我们将继续并增加向研究HIV发病机制的合格研究人员提供来自HIV感染者的信息、组织和体液，并继续招募HIV感染者加入器官捐献计划，并在该计划之前进行纵向研究。神经学、神经心理学和精神病学研究。 无论是单独还是与其他 NNTC 站点一起，我们将检查死前功能与死后病理学的传统临床病理相关性，并检查神经艾滋病疾病的纵向进展。 我们还将在艾滋病毒阴性对照队列中创建一个器官捐赠计划，该计划将作为病毒学控制材料的来源，并有助于剖析肝脏对神经艾滋病疾病的影响。 具体来说，将招募一组具有明确死亡风险的移植前肝病患者参加器官捐赠计划，并使用 NNTC 一系列测试进行纵向研究。 我们将继续关注 HIV 相关中枢神经系统和三七总皂甙疾病的共病和健康差异，特别是定义肝病、物质障碍和艾滋病毒对认知和神经功能障碍的影响。