Voltage-gated K channels, microglia and HIV Dementia

电压门控 K 通道、小胶质细胞和 HIV 痴呆

• 批准号: 8138841
• 负责人: HUANGUI Hank XIONG
• 金额: $ 37.13万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8138841
• 关键词: 4-Aminopyridine; AIDS Dementia Complex; Address; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Apoptotic; Applications Grants; Area; Attention; Attenuated; Basal Ganglia; Behavior; Biological Assay; Brain; Brain Injuries; CCL2 gene; CCR5 gene; CXCR4 gene; Cell Culture Techniques; Cell model; Cells; Central Nervous System Diseases; Characteristics; Chemokine (C-C Motif) Receptor 5; Coculture Techniques; Cognition; Collaborations; Computer software; Computers; Control Animal; Cues; Culture Media; Cyclic AMP-Dependent Protein Kinases; Cytotoxin; Disease; Emission-Computed Tomography; Exposure to; Figs - dietary; Functional disorder; Funding; GTP-Binding Proteins; Genes; Glycoproteins; Goals; HIV; HIV Envelope Protein gp120; HIV Infections; HIV encephalitis; HIV-1; Hippocampus (Brain); Human; Immigration; Immune; Immune system; Immunotherapy; Impaired cognition; Impairment; In Situ Nick-End Labeling; In Vitro; Infection; Inflammatory; Inflammatory Response; Injection of therapeutic agent; Ion Channel; Ions; Kir2.1 channel; Label; Laboratory Animal Models; Learning; Link; MAP Kinase Gene; MAPK14 gene; Measures; Mediating; Memory; Microglia; Minocycline; Mitogen-Activated Protein Kinase Inhibitor; Modeling; Molecular; Monocyte Chemoattractant Protein-1; Mus; Nerve Degeneration; Neurocognitive; Neurodegenerative Disorders; Neuronal Dysfunction; Neuronal Injury; Neurons; Neurosciences; Neurotoxins; Nitric Oxide; Patch-Clamp Techniques; Pathogenesis; Pathway interactions; Patients; Pattern; Pharmacology; Phosphorylation; Phosphorylation Site; Photons; Play; Potassium; Process; Production; Protein Kinase A Inhibitor; Protein-Serine-Threonine Kinases; Protocols documentation; Radial; Radioactivity; Rattus; Regulation; Research; Rest; Reverse Transcriptase Polymerase Chain Reaction; Role; SB 203580; SCID Mice; Signal Pathway; Signal Transduction Pathway; Slice; Small Interfering RNA; Staining method; Stains; Stimulus; Synaptic Transmission; System; T140 peptide; Techniques; Testing; Therapeutic; Time; Tissues; Up-Regulation; Vesicular stomatitis Indiana virus; Voltage-Gated Potassium Channel; Water; Western Blotting; Work; analog; arm; base; behavior test; bioimaging; brain tissue; caspase-3; cell motility; cell type; channel blockers; combat; cytokine; design; digital imaging; human disease; human subject; immunoregulation; in vivo; inhibitor/antagonist; injured; interest; lenalidomide; macrophage; migration; monocyte; nervous system disorder; neuron apoptosis; neuropathology; neuroprotection; neurotoxic; neurotoxicity; prevent; professor; protective effect; receptor; relating to nervous system; research study; therapeutic development; tomography; voltage