CORE--CHEMISTRY AND PET IMAGING

核心——化学和宠物成像

• 批准号: 7848302
• 负责人: JORGE R BARRIO
• 金额: $ 32.97万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7848302
• 关键词: Aging; Animals; Applications Grants; Biological; Chemistry; Collaborations; Computer Systems; Cyclotrons; Data; Data Collection; Dementia; Ensure; Equipment; Gamma counter; Human; Image; Image Analysis; Life; Magnetic Resonance Imaging; Measurement; Methods; Modeling; Molecular; Neurofibrillary Tangles; Operative Surgical Procedures; Positron-Emission Tomography; Product Labeling; Production; Program Research Project Grants; Protocols documentation; Quality Control; Radiation; Radioisotopes; Radiolabeled; Radiopharmaceuticals; Reagent; Regulation; Research; Research Personnel; Resources; Running; Scanning; Schedule; Senile Plaques; System; Techniques; Transgenic Mice; human subject; image reconstruction; imaging probe; instrument; instrumentation; molecular imaging; programs; radiochemical; radiotracer; research study

The Chemistry and PET Imaging Core will use the resources of two technical centers in the UCLA PET program: the Molecular Imaging Probe Production and the PET Imaging Instrumentation. The Molecular Imaging Probe Production Technical Center is responsible for the production of all the radiopharmaceuticals for the project included in this application. A wide range of products labeled with O-15, N-13, C-11 and F-18 are routinely synthesized, purified and provided to various investigators under a variety of different protocols. This Technical Center continually explores new radioisotope production techniques, new precursor syntheses and new radiolabeled reagents. It also focuses its activities in improvement of the radiochemical yields of established methods, new automated radiosynthesis modules and ways to reduce personal radiation exposures. For this Program Project grant the Technical Center will provide [18F]FDG, [18F]FDDNP and [18F]MPPF. The PET Imaging Instrumentation Core provides and supports the imaging instruments used by all Program investigators. It ensures that all instruments are maintained and kept in good running order and performs the periodic daily/monthly quality contol. It also educates investigators about the capabilities and limitations of the instruments and assists them in planning and executing their experiments. It ensures the quantitative accuracy of their measurements (wherever applicable) and in collaboration with the Computation and Modeling Tech Center (Image Analysis Core: Sung Cheng Huang, Core Leader) guides investigators in their data interpretation. In addition it ensures the proper data archival and storage, as well as compliance of investigators with all local, state and federal regulations governing molecular imaging research with animals and humans. This Core will provide and maintain the necessary tomographic and ancillary equipment and resources to perform human PET and microPET scans proposed in this grant application; perform periodic quality controls; implement and maintain detailed logs of all the operations; coordinate, schedule and optimize the use of all the tomographs and ancillary equipment (i.e. gamma counters) necessary in this application with the cyclotron production of short-lived molecular imaging probes; maintain and upgrade tomographic equipment and computer systems for data collection, image reconstruction and transfer; assist investigators in planning and performing studies with the imaging systems, including compliance with all local, state and federal regulations to conduct biological imaging research with animals and humans.

化学和 PET 成像核心将利用 UCLA PET 项目中两个技术中心的资源：分子成像探针生产和 PET 成像仪器。分子影像探针生产技术中心负责本申请项目所有放射性药物的生产。常规合成、纯化各种标有 O-15、N-13、C-11 和 F-18 的产品，并根据各种不同的方案提供给各种研究人员。该技术中心不断探索新的放射性同位素生产技术、新的前体合成和新的放射性标记试剂。它还将其活动重点放在提高现有方法的放射化学产量、新的自动放射合成模块以及减少个人辐射暴露的方法上。对于该计划项目拨款，技术中心将提供[18F]FDG、[18F]FDDNP 和[18F]MPPF。 PET 成像仪器核心提供并支持所有计划研究人员使用的成像仪器。它确保所有仪器得到维护并保持良好的运行状态，并执行定期的每日/每月质量控制。 它还向研究人员介绍仪器的功能和局限性，并帮助他们规划和执行实验。它确保测量的定量准确性（在适用的情况下），并与计算和建模技术中心（图像分析核心：Sung Cheng Huang，核心负责人）合作指导研究人员进行数据解释。此外，它还确保正确的数据归档和存储，以及研究人员遵守所有地方、州和联邦分子管理法规 动物和人类的成像研究。该核心将提供并维护必要的断层扫描和辅助设备及资源，以执行本拨款申请中提出的人体 PET 和 microPET 扫描；进行定期质量控制；实施并维护所有操作的详细日志；协调、安排和优化本应用中所需的所有断层扫描仪和辅助设备（即伽马计数器）的使用以及回旋加速器生产的短寿命分子成像探针；维护和升级断层扫描设备和计算机系统，以进行数据收集、图像重建和传输；协助 研究人员使用成像系统规划和执行研究，包括遵守所有地方、州和联邦法规，以对动物和人类进行生物成像研究。