Real-Time Digital Autoradiography System

实时数字放射自显影系统

• 批准号: 7794778
• 负责人: Todd E Peterson
• 金额: $ 15.99万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-29 至 2011-07-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794778
• 关键词: Animals; Applications Grants; Autoradiography; Biological Process; Bioluminescence; Core Facility; Data; Fluorescence; Funding; Image; Institutes; Investigation; Magnetic Resonance Imaging; Metric; Microtome - medical device; Positron-Emission Tomography; Process Assessment; Qualifying; Radiolabeled; Research Project Grants; Resolution; Resources; Science; Scientist; System; Therapeutic Intervention; Time; Training Programs; Ultrasonography; Universities; Validation; X-Ray Computed Tomography; cancer imaging; digital; experience; imaging modality; in vivo; instrumentation; molecular imaging; radiotracer; single photon emission computed tomography; tissue slice preparation

DESCRIPTION (provided by applicant): This shared instrumentation grant proposal is for the purchase of a digital, real-time autoradiography system with multiple radiolabel capability. The NIH-funded research projects that require this system are aimed primarily at developing new molecular imaging agents and validating existing radiotracers for the investigation of fundamental biological processes and the assessment of the impact of therapeutic interventions. The system will be located in the Center for Small Animal Imaging (CSAI) alongside systems representing the major in vivo imaging modalities (ultrasound, bioluminescence/fluorescence, X-ray CT, PET, SPECT, MRI and MRS). The CSAI also has a cryo-microtome that will facilitate the preparation of tissue slices for autoradiography. A key benefit of the autoradiography capability to many of the studies will be the opportunity to obtain high-resolution, quantitative data to assist in the interpretation and validation of in vivo imaging metrics. The CSAI functions as a Core Facility for the university and operates as part of the Vanderbilt University Institute of Imaging Science. The autoradiography system will be supported by an experienced group of imaging scientists and a highly qualified support staff. It also will be a key resource for postdoctoral trainees supported by our institutional training program in cancer imaging as well as our other trainees in imaging science.

描述（由申请人提供）：该共享仪器拨款提案用于购买具有多种放射性标记功能的数字实时放射自显影系统。美国国立卫生研究院资助的需要该系统的研究项目主要旨在开发新的分子成像剂并验证现有的放射性示踪剂，以研究基本生物过程并评估治疗干预的影响。该系统将位于小动物成像中心 (CSAI)，旁边还有代表主要体内成像模式（超声波、生物发光/荧光、X 射线 CT、PET、SPECT、MRI 和 MRS）的系统。 CSAI 还拥有一台冷冻切片机，有助于制备用于放射自显影的组织切片。放射自显影能力对许多研究的一个主要好处是有机会获得高分辨率的定量数据，以协助解释和验证体内成像指标。 CSAI 是大学的核心设施，是范德比尔特大学影像科学研究所的一部分。放射自显影系统将由经验丰富的成像科学家团队和高素质的支持人员提供支持。它也将成为我们癌症成像机构培训计划支持的博士后学员以及成像科学其他学员的重要资源。