New Horizons in Adult Neurogenesis

成人神经发生的新视野

• 批准号: 8787461
• 负责人: AMELIA J EISCH
• 金额: $ 12.04万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8787461
• 关键词: Addictive Behavior; Address; Adult; Affect; Affinity Chromatography; Amelia; Animal Model; Applications Grants; Award; Bacterial Artificial Chromosomes; Behavior; Behavioral; Brain; Brain region; Candidate Disease Gene; Cells; Clinical; Cocaine; Cocaine Dependence; Cognitive deficits; Collaborations; Complex; Cues; Data; Data Collection; Detection; Development; Development Plans; Disease; Dissection; Doctor of Philosophy; Dose; Drug Addiction; Drug usage; Electrophysiology (science); Environment; Extinction (Psychology); Funding; Future; Goals; Grant; Health; Heroin; Hippocampus (Brain); Human; Immediate-Early Genes; Immunohistochemistry; Independent Scientist Award; Knowledge; Lead; Learning; Life; Light; Link; Medical center; Memory; Mentors; Molecular; Molecular Genetics; Morphine; Morphine Dependence; Morphology; Mus; National Institute of Drug Abuse; Neurons; Neurosciences; Opiate Addiction; Opiates; Pathway interactions; Pharmaceutical Preparations; Phase; Predisposing Factor; Process; Psychiatry; Publications; RNA; Recovery; Relapse; Research; Rewards; Ribosomes; Role; Running; Secure; Self-Administered; Series; Source; Stress; Structure; Symptoms; Synapses; Techniques; Testing; Time; Translating; Withdrawal; Work; addiction; adult neurogenesis; base; behavioral response; career; career development; dentate gyrus; drug of abuse; drug relapse; drug reward; improved; in vivo; indexing; injured; insight; nerve stem cell; neuroadaptation; neurogenesis; novel; novel strategies; optogenetics; professor; relating to nervous system; repaired; response; social; stem cell biology

DESCRIPTION (provided by applicant): This is a renewal application for a NIDA Independent Scientist Award (K02). The candidate, Amelia J. Eisch, Ph.D., is a tenured Associate Professor in the Department of Psychiatry at UT Southwestern Medical Center. Dr. Eisch is a pioneer in understanding the reciprocal relationship between certain forms of hippocampal plasticity such as adult hippocampal neurogenesis and behaviors relevant to addiction. The first award period of this K02 provided Dr. Eisch with the protected time she needed to accomplish her past goals, which included renewing her NIDA R01 grant on opiates and neurogenesis, securing additional federal funding, advancing her work from correlative to more mechanistic and "causative" studies, and being promoted to Associate Professor and receiving tenure. This K02 renewal is requested in order to continue this protected time and to allow Dr. Eisch to utilize the momentum she has established in understanding the proposed reciprocal role between new neurons in the adult brain and addiction. The receipt of a K02 renewal award would allow her continued protection from administrative burdens, and thus allow Dr. Eisch to advance: (1) research on the relationship between adult-generated neurons and behaviors relevant to addiction; (2) dissection of the cellular, molecular, and genetic control of adult-generated hippocampal neurons; (3) newly developed collaborations on translational profiling, ultrastructural analysis, and circuit-level impact of new neurons; (4) application of new techniques for these collaborations (BAC-TRAP, optogenetics, EM, electrophysiology); (5) data collection for grant applications: the 10-year renewal of her existing R01 on opiates and neurogenesis, a new NIDA R01 relevant to the molecular control of hippocampal neurogenesis, and a new NIDA R01 relevant to behavioral and circuit-level impact of adult-generated neurons. By providing this protected time, Dr. Eisch can work closely with her collaborators and rapidly advance her new ideas, thus benefitting the fields of addiction research and stem cell biology and neuroscience as a whole. The stability and protected time offered by this K02 award would ultimately support at least two new projects exploring the intriguing relationship between adult-generated hippocampal neurons and behaviors relevant to addiction. As these studies hold great potential to improve our understanding of the complex mechanisms by which drugs of abuse affect brain function, they therefore may open new avenues for treatment of addiction and relapse to drug seeking. As these studies also will also shed much-needed light on how adult-generated neurons influence complex behavior - such as drug/context association, extinction from drug-seeking, and behavioral response to stress - they will be important to future efforts to harness neural stem cells for repair of the injured, even addicted, brain and to our understanding of what new neurons can/will do in the adult brain.

描述（由申请人提供）：这是NIDA独立科学家奖（K02）的续签申请。候选人Amelia J. Eisch博士是UT西南医学中心精神病学系的终身副教授。 Eisch博士是理解某些形式的海马可塑性（例如成年海马神经发生和与成瘾有关的行为）之间相互关系的先驱。该K02的第一个奖项为EISCH博士提供了实现过去目标所需的受保护时间，其中包括更新她的NIDA R01 R01拨款和神经发生，确保了额外的联邦资金，将她的工作从相关性到更具机械性和“造成性”研究提高，并晋升为副教授和接收任期。要求进行此K02续订，以便继续这一受保护的时间，并允许Eisch博士利用她在理解成人大脑和成瘾中新神经元之间提出的相互作用时所建立的势头。获得K02更新裁决的收到将使她继续保护行政负担，从而允许Eisch博士进步：（1）研究成人生成的神经元与与成瘾有关的行为之间的关系； （2）对成人产生海马神经元的细胞，分子和遗传控制的解剖； （3）新开发的关于新神经元的翻译分析，超微结构分析和电路级影响的合作； （4）将新技术应用于这些合作（BAC-TRAP，光遗传学，EM，电生理学）； （5）授予应用的数据收集：她现有的R01在阿片类药物和神经发生上的10年续订，与海马神经发生的分子控制有关的新的NIDA R01，以及与成人生成神经元的行为和电路级别有关的新NIDA R01。通过提供这个受保护的时间，Eisch博士可以与她的合作者紧密合作，并迅速发展她的新想法，从而使成瘾研究和干细胞生物学和整体神经科学领域受益。该K02奖提供的稳定性和受保护的时间最终将至少支持两个新项目，探讨成人生成的海马神经元与与成瘾有关的行为之间的有趣关系。由于这些研究具有巨大的潜力，可以提高我们对滥用药物影响大脑功能的复杂机制的理解，因此它们可能为治疗成瘾和对药物的复发提供新的途径。由于这些研究还将对成年产生的神经元如何影响复杂行为（例如药物/情境关联，寻求药物的灭绝以及对压力的行为反应灭绝）的急需阐明 - 它们对于未来的努力来利用神经干细胞修复受伤的，甚至上瘾，大脑，以及我们对新神经元的理解/在成人大脑中所做的事情。