Structural and Neurometabolic White Matter Integrity in the Deficit Syndrome

缺陷综合征中的结构和神经代谢白质完整性

基本信息

批准号：
9033607
负责人：
Nina Vanessa Kraguljac
金额：
$ 17.74万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-16 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9033607
关键词：
Anisotropy Applications Grants Attenuated Autopsy Biological Markers Blood flow Brain Brain imaging Categories Characteristics Clinical Development Diffusion Magnetic Resonance Imaging Disease Enrollment Functional Magnetic Resonance Imaging Glutamates Glutamine Goals Image Impairment Inferior Intervention Knowledge Lead Magnetic Resonance Spectroscopy Matched Group Measurement Measures Mental disorders Multimodal Imaging N-acetylaspartate Neuroglia Neuronal Plasticity Neurons Onset of illness Outcome Parietal Parietal Lobe Patients Pattern Prevalence Preventive Principal Investigator Process Psychiatric Diagnosis Psychotic Disorders Quality of life Reporting Research Rest Risk Schizophrenia Severity of illness Specificity Structure-Activity Relationship Subgroup Symptoms System Taxonomy Techniques Testing Tissues Training Translational Research base biosignature brain circuitry career clinical phenotype deficit syndrome first episode psychosis first episode schizophrenia in vivo indexing longitudinal design mental development myoinositol neuroimaging neurophysiology neuropsychological outcome forecast prognostic public health relevance relating to nervous system white matter

项目摘要

DESCRIPTION (provided by applicant): The current system of psychiatric diagnosis does not include characteristics that delineate patterns of symptoms, severity of illness or prognostic features. This greatly hinders progress in our understanding of mental illness and development of more specific treatments. The deficit syndrome is thought to be a more homogeneous subgroup of schizophrenia that is characterized by primary and enduring negative symptoms. It is associated with greater global impairment, lower quality of life, and poorer long-term outcome. We propose to use multimodal neuroimaging to study 20 schizophrenia patients with the deficit syndrome, 20 schizophrenia patients without the deficit syndrome, and 20 matched healthy controls. We will use (1) Diffusion Tensor Imaging to measure structural white matter integrity, (2) Magnetic Resonance Spectroscopy to measure neurometabolic white matter integrity, and (3) resting state functional MRI to measure functional connectivity to test the hypotheses that white matter integrity and related functional connectivity patterns differ between deficit and non-deficit schizophrenia. Using complementary neuroimaging techniques will allow generating a broad characterization of structural and neurometabolic white matter abnormalities and their functional consequences in the deficit syndrome. The results of proposed study might not only lead to identification of biomarkers that can assist in identification of patients at risk for developing the deficit syndrome before the clinical picture manifests, it will also provide the training necessary to prepare the candidate for an independent research career with focus on translational research in psychotic disorders.

描述（由适用提供）：当前的精神诊断系统系统不包括描述症状模式，疾病严重性或进展的特征。这很大程度上阻碍了我们对精神疾病和发展更具体治疗的发展的进步。赤字综合征被认为是精神分裂症的更均匀的亚组，其特征是原发性和持久的负面症状。与更大的全球障碍，较低的生活质量和较差的长期结果有关。我们建议使用多模式神经影像学来研究20名缺陷综合征的精神分裂症患者，20名没有赤字综合征的精神分裂症患者以及20种匹配的健康对照。我们将使用（1）扩散张量成像测量结构白质完整性，（2）磁共振光谱以测量神经代谢白质完整性，以及（3）静止状态功能MRI以测量功能连接性以测试功能连接以测试白质完整性和相关功能连接模式在缺陷和非缺陷和非缺乏和非缺乏症之间不同的假设。使用完整的神经影像技术将允许对结构和神经代谢白质异常的广泛表征及其在赤字综合征中的功能后果。拟议研究的结果不仅可能导致生物标志物的鉴定，这些标志物可以帮助鉴定出在临床图片表现之前患有缺陷综合征的患者，还将提供必要的培训，以准备候选人为独立研究职业准备，重点是精神疾病的转化研究。