Flu vaccine effectiveness in those hospitalized in a large diverse health system

流感疫苗对大型多元化卫生系统住院患者的有效性

• 批准号: 10227644
• 负责人: RICHARD K ZIMMERMAN
• 金额: $ 72.6万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227644
• 关键词: Flu; vaccine; effectiveness; those; hospitalized

 DESCRIPTION (provided by applicant): The elderly suffer the majority of influenza hospitalizations and deaths and are a priority for determining influenza vaccine effectiveness (VE). The Univ. of Pittsburgh and UPMC Health System (UPMC) are located in Allegheny County (AC), in which influenza is reportable & which has one of the 5 oldest populations in the U.S. We propose a test-negative case-control study of influenza VE in 2 UPMC hospitals to determine VE against hospitalizations of adults. UPMC has been on the US News honor roll for over a decade, including "most wired" and has a strong research tradition. The influenza season will be determined from syndromic surveillance from multiple hospital EDs, the Health Dept. (ACHD), & from lab data from >14,000 respiratory viral panels (RVP) done annually at UPMC. Theradoc informatics will identify adult inpatients who have had an RVP conducted. Enrollees' survey data will be directly entered into NIH's REDCap. Frailty can be assessed by survey and/or electronic medical record (EMR) data (e.g., Charleson Co-morbidity Index) to assess confounders and effect modifiers. Our Data Center manages REDCap data, EMR data from hospitalizations, & immunization data for uploading to CDC. Population-based incidence of influenza hospitalizations will be determined from ACHD and UPMC St. Margaret hospitalization data and by agent-based modeling at the Pittsburgh Supercomputing Center. Our team is a strong candidate for this project because: 1) UPMC is the dominant regional health system with a strong bond rating; 2) infection control personnel recommend RVPs to establish diagnoses, and our team's leadership responsibilities at the hospitals can further influence the use of RVPs; 3) we have published data showing excellent concordance between UPMC's GenMark RVP and the CDC's PCR for detecting influenza; 4) research shows better protection in the elderly from high-dose influenza (HD) vaccine; UPMC has recommended and promoted HD vaccine in large quantities, although regular vaccine is available, allowing for vaccine type comparisons; 5) UPMC's EMR links inpatient and outpatient vaccination records, and interfaces with the state immunization registry; 6) it includes diverse, well-published investigators who have worked together previously.

 描述（由申请人提供）： 老年人因流感住院和死亡，是确定流感疫苗有效性 (VE) 的优先对象 匹兹堡大学和 UPMC 卫生系统 (UPMC) 位于阿勒格尼县 (AC)。 ，其中流感是可报告的，并且是美国 5 个最古老的人口之一。我们建议在 2 家 UPMC 医院进行流感 VE 测试阴性病例对照研究，以确定 UPMC 成人住院的 VE。十多年来一直名列《美国新闻》荣誉榜，包括“最连线”，并且具有强大的研究传统，流感季节将根据多家医院急诊室、卫生部门 (ACHD) 和实验室的症状监测来确定。 UPMC 每年进行的超过 14,000 份呼吸道病毒检测 (RVP) 数据将识别进行过 RVP 的成年住院患者，其调查数据将直接输入 NIH 的 REDCap。可以通过调查和/或电子病历 (EMR) 数据（例如 Charleson 合并症指数）来评估虚弱情况，以评估混杂因素和效应修正因素。我们的数据中心管理 REDCap 数据、住院 EMR 数据以及上传到的免疫数据。 CDC。基于人群的流感住院发生率将根据 ACHD 和 UPMC 圣玛格丽特住院数据以及匹兹堡超级计算中心基于代理的模型来确定。我们的团队是该项目的有力候选者。因为：1) UPMC 是主要的地区卫生系统，具有很强的债券评级；2) 感染控制人员推荐 RVP 来建立诊断，而我们团队在医院的领导职责可​​以进一步影响 RVP 的使用；3) 我们已经发布了数据；显示 UPMC 的 GenMark RVP 与 CDC 检测流感的 PCR 之间具有极好的一致性；4) 研究表明，大剂量流感 (HD) 疫苗可以更好地保护老年人； UPMC 已推荐并大规模推广 HD 疫苗；尽管有常规疫苗可供使用，但可以进行疫苗类型比较；5) UPMC 的 EMR 将住院患者和门诊疫苗接种记录联系起来，并与州免疫登记处进行交互；6) 它包括以前合作过的不同的、发表过大量文章的研究人员。