Animal Behavior & Neurophysiology

动物行为

基本信息

批准号：
10085504
负责人：
Deborah A Cory-Slechta
金额：
$ 18.45万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10085504
关键词：
Affect Animal Behavior Animal Model Behavior Behavioral Behavioral Assay Biological Assay Cells Cognition Complex Analysis Computer software Consultations Data Data Collection Development Ensure Equipment Faculty Generations Genes Goals Individual Infrastructure Intellectual and Developmental Disabilities Research Centers Intervention Investigation Laboratories Laboratory Research Leadership Link Measures Methodology Methods Neurons Neurosciences Research Phase Play Population Protocols documentation Reproducibility Research Research Personnel Research Project Grants Resources Rodent Model Sensory Social Behavior Techniques Training Universities Work analytical method behavioral study design experimental study insight large datasets medical schools member morris water maze neuronal patterning neurophysiology new technology relating to nervous system social theories

项目摘要

Project Summary: The URMC IDDRC Animal Behavior and Neurophysiology (ABN) Core will provide IDDRC members with access to behavioral and neurophysiological assays in rodent models that harness the expertise of the Core leadership and allow for investigation of the neural underpinnings of IDDs. The Core’s Components in animal behavior and neurophysiology are already central to work being conducted by IDDRC investigators, providing access to equipment, techniques, and analyses that are central to current neuroscience research. By providing access to well established assays that are essential to IDD research, the animal behavior component of the Core allows investigators to relate changes at the gene, cell, and circuit level in the animal models to behaviors that may provide mechanistic insight into IDDs. Similarly, by providing access to single neuron, multiunit, and population activity measures, the neurophysiology component of the core allows investigators to further establish bridges that link changes in patterns of neuronal activity to behavioral changes that may underlie a number of IDDs. Both components of the Core have continued to advance and validate new technologies; both are also critical to the Research Project. The ABN Core will be supported by dedicated administrative and technical faculty and staff to provide critical expertise in the design, implementation, and analysis of both behavioral and neurophysiological assays critical to IDD research. To achieve this, three Aims are proposed. Aim 1 is to provide vital access to resources (both equipment and expertise) for carrying out behavioral and neurophysiological assays critical to IDDRC investigator research. Aim 2 will provide technical and methodological guidance and support to generate data in both behavioral and neurophysiological assays critical to IDDRC investigator research. Aim 3 will provide analysis and statistical guidance and support to interpret data in both behavioral and neurophysiological assays critical to IDDRC investigator research. Collectively, the ABN Core of the URMC IDDRC will allow investigators to perform behavioral and neurophysiological assays in animal models to gain insight into the neural underpinnings of IDDs. Through its interactions with other IDDRC Cores, it will advance the long-term goal of identifying interventions and treatments at the cellular, neurophysiological, and behavioral levels.

项目摘要：URMC IDDRC 动物行为和神经生理学 (ABN) 核心将提供 IDDRC 成员可以利用专业知识在啮齿动物模型中进行行为和神经生理学检测核心领导力并允许研究 IDD 的神经基础。动物行为和神经生理学的组成部分已经成为 IDDRC 正在进行的工作的核心调查人员，提供对当前至关重要的设备、技术和分析的访问通过提供对 IDD 研究至关重要的成熟检测方法，核心的动物行为部分允许研究人员将基因、细胞和电路的变化联系起来动物模型中的行为水平可以提供对 IDD 的机制洞察。获得单神经元、多单元和群体活动测量，神经生理学组成部分 core 允许研究人员进一步建立将神经活动模式的变化与可能导致许多 IDD 的行为变化仍在继续。推进和验证新技术；两者对于 ABN 核心也至关重要。由专门的行政和技术教职员工支持，提供设计方面的关键专业知识，对 IDD 研究至关重要的行为和神经生理学测定的实施和分析。为了实现这一目标，提出了三个目标：目标 1 是提供对资源（设备和资源）的重要访问。专业知识），用于进行对 IDDRC 研究者研究至关重要的行为和神经生理学测定。目标 2 将提供技术和方法指导和支持，以生成行为和行为方面的数据。对 IDDRC 研究者研究至关重要的神经生理学测定将提供分析和统计。指导和支持解释对 IDDRC 至关重要的行为和神经生理学测定中的数据总的来说，URMC IDDRC 的 ABN 核心将允许研究人员进行研究。在动物模型中进行行为和神经生理学测定，以深入了解神经基础通过与其他 IDDRC 核心的互动，它将推进识别的长期目标。细胞、神经生理学和行为水平的干预和治疗。