H2A Admin Core

H2A 管理核心

• 批准号: 10084612
• 负责人: Gregory D Kirk
• 金额: $ 26.51万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-09 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10084612
• 关键词: Accounting; Advocate; Africa; Africa South of the Sahara; African; Age; Biological Specimen Banks; Cell Nucleus; Clinical; Collaborations; Communication; Communities; Computer software; Country; Data Collection; Database Management Systems; Development; Documentation; Electronic Mail; Ensure; Face; Generations; Goals; Grant; HIV; Hepatitis B; Hepatitis B Virus; Hepatitis C virus; Human; Infection; Intercept; International; Interruption; Lead; Leadership; Link; Malignant Neoplasms; Medical; Mentors; Monitor; Online Systems; Patient Recruitments; Patients; Peer Review; Periodicity; Policies; Preparation; Primary carcinoma of the liver cells; Problem Solving; Progress Reports; Public Relations; Publications; Reporting; Research; Research Personnel; Resources; Review Literature; Risk Factors; Role; Schistosoma mansonii infection; Senegal; Site; Structure; Supervision; Time; Training; Uganda; Universities; Work; chronic infection; data harmonization; data sharing; expectation; human subject protection; meetings; organizational structure; participant retention; programs; symposium; web site

Hepatocellular carcinoma (HCC) is a very common and lethal cancer in Africa, and as patients with HIV live longer, the HCC burden may increase. In prior studies, our team identified chronic infection with hepatitis B and C viruses (HBV, HCV), HIV and Schistosomiasis mansoni as independent risk factors for HCC. Compared to the US, HCC in sub-Saharan Africa occurs at younger age and more advanced stage with survival of only months. Proposed is an East and West African partnership between colleagues at Makerere University in Uganda, Fann University in Senegal and Johns Hopkins University focused on HIV and hepatocellular carcinoma (HCC) in Africa: The H2A Consortium. Building on long-standing collaborative research, mentoring and clinical activities in both countries, our overarching goal is to reduce the heavy burden of HCC in sub- Saharan Africa. We advocate investigating cancer interception strategies using appropriate medical treatments to interrupt or reverse the impact of these HCC-causing infections. The Administrative and Coordinating Core (ACC) will provide overall leadership for implementing the scientific agenda of the H2A consortium. Using best practices from decades of international research collaboration, the H2A Consortium proposes an effective organizational structure and strong leadership with a track record of international research collaboration. The organizational framework builds upon the ongoing close working relationship between prior co-PIs from Uganda and Hopkins and welcomes the Senegalese team as equal partners. The ACC will establish transparent structures to support rigorous study oversight, effective communication, and efficient problem- solving. The H2A Consortium effectively integrates ACC activities within a closely interacting Steering Committee (SC) comprised of the Overall Co-Leaders and the Project /Core PIs. For each Project or Core, the leadership represents an equitable partnership with PIs from each site sharing responsibilities. This leadership nucleus is further supported by an External Advisory Panel (EAP) and a Community Advisory Panel (CAP), with collaborative links to NCI Program leadership and other U54 Consortia sites. The impact of our integrated research and capacity development activities will be establishment of the H2A Consortium as partnered Centers of Excellence on HIV and HCC in East and West Africa.

肝细胞癌 (HCC) 是非洲一种非常常见且致命的癌症，随着艾滋病毒患者的生存 时间越长，HCC 负担可能会增加。在之前的研究中，我们的团队发现了乙型肝炎的慢性感染 C 病毒（HBV、HCV）、HIV 和曼氏血吸虫病是 HCC 的独立危险因素。比较的 与美国相比，撒哈拉以南非洲地区的 HCC 发生年龄更小，阶段更晚期，生存期仅为 几个月。提议在马凯雷雷大学的同事之间建立东非和西非伙伴关系 乌干达、塞内加尔范恩大学和约翰霍普金斯大学专注于艾滋病毒和肝细胞 非洲癌症 (HCC)：H2A 联盟。建立在长期合作研究、指导的基础上 以及两国的临床活动，我们的总体目标是减轻亚裔 HCC 的沉重负担 撒哈拉非洲。我们主张使用适当的医疗方法研究癌症拦截策略 中断或扭转这些引起 HCC 的感染的影响。行政及协调 Core (ACC) 将为实施 H2A 联盟的科学议程提供全面领导。使用 根据数十年国际研究合作的最佳实践，H2A 联盟提出了一种有效的 组织结构和强有力的领导力以及国际研究合作的记录。这 组织框架建立在前联合PI之间持续密切的工作关系之上 乌干达和霍普金斯欢迎塞内加尔队成为平等伙伴。 ACC 将建立 透明的结构支持严格的研究监督、有效的沟通和高效的问题解决 解决。 H2A 联盟有效地将 ACC 活动整合到紧密互动的指导中 委员会 (SC) 由总体联合领导者和项目/核心 PI 组成。对于每个项目或核心， 领导力代表着与每个站点的 PI 之间的公平合作伙伴关系，分担责任。这个领导 nucleus 得到外部咨询小组 (EAP) 和社区咨询小组 (CAP) 的进一步支持， 与 NCI 项目领导层和其他 U54 联盟网站的协作链接。我们综合的影响 研究和能力开发活动将建立 H2A 联盟作为合作伙伴 东非和西非艾滋病毒和肝癌卓越中心。