High Spatial and Temporal Resolution Imaging Core
高时空分辨率成像核心
基本信息
- 批准号:10077906
- 负责人:
- 金额:$ 20.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalApplications GrantsAreaBiological ProcessBiomedical ResearchCardiovascular systemCellsCellular StructuresCenters of Research ExcellenceCore FacilityDiseaseEquipmentFeesFluorescence Resonance Energy TransferFundingFutureGenerationsGoalsHealthHuman ResourcesImageIndividualInfrastructureInternationalLabelLaboratoriesLogisticsMedicalMethodological StudiesMicroscopeMicroscopyMolecularMolecular MedicineNevadaPharmacologyPhasePreparationResearchResearch PersonnelResearch Project GrantsResolutionSamplingScienceServicesSignal PathwaySignal TransductionSpecialistStructureSupervisionSystemTechnologyTimeTissue SampleTrainingUniversitiesVisualizationbasebiological systemsdesignexperimental studyfluorescence microscopehigh resolution imagingimaging modalityinstrumentinstrumentationinterestinvestigator trainingmedical schoolsnew technologyoperationtemporal measurementtwo-photon
项目摘要
Project Summary
The goal of the present proposal is to establish and provide support for a High Spatial and Temporal Resolution
Imaging Core (HSTRI or Core C) facility that will offer a wide array of state- of-the-art instruments enabling
visualization of cells and tissues samples pharmacologically or genetically labeled with fluorescent indicators.
With the assistance of expert staff and unrestricted access to these instruments, we expect Core C to greatly
enhance the competitiveness of Project Leaders in grant applications, and promote their recognition and
contributions to their respective fields at the national and international level. This facility is specifically designed
to meet the needs of our Project Leaders, but will also enhance the overall capacity for biomedical research at
the University of Nevada, Reno, and UNR School of Medicine. Core C will accomplish the following Specific
Aims during Phase I of the COBRE: Specific Aim 1: To establish, maintain, and operate a facility providing
state-of-the-art high spatial and temporal resolution imaging methodologies for studying cellular
structure, signaling pathways, and function in health and disease. Recent advances in microscopy have
produced a generation of commercially available instruments that provide biomedical researchers the ability to
investigate the relationship between structure and function of biological systems with unprecedented spatial and
temporal resolution, near or below the diffraction limit. The goal of this Specific Aim is to make high spatial and
temporal resolution imaging available as a core facility to COBRE investigators. A comprehensive core
management plan will be implemented to effectively maintain the infrastructure of this core and prioritize access
of core services to COBRE investigators. Specific Aim 2: To advise and train investigators in the use of the
new technologies. Training users in the operation of the HSTRI core equipment and appropriate sample
preparation, as well as educating them about the scientific possibilities offered by these facilities, is a crucial part
of maximizing the core's impact on biomedical research. Core personnel will provide appropriate training and
supervision of users. Specific Aim 3: To develop a user base and an operational plan that will sustain the
core in the long-term. Plans will be developed to sustain support for the Core during and after the end of the
funded period through user fees. HSTRI core services will also be offered to non-COBRE investigators on a
recharge basis during time slots not reserved by COBRE investigators. Many well-funded labs at UNR Med and
UNR have expressed interest in incorporating high resolution imaging methods into their research and future
grant applications.
项目概要
本提案的目标是建立高空间和时间分辨率并为其提供支持
成像核心(HSTRI 或 Core C)设施将提供各种最先进的仪器,使
用荧光指示剂药理学或基因标记的细胞和组织样品的可视化。
在专家人员的协助和不受限制地使用这些工具的情况下,我们期望 Core C 能够大大提高
提高项目负责人在资助申请中的竞争力,并促进他们的认可和认可
在国家和国际层面对各自领域做出的贡献。这个设施是专门设计的
以满足我们项目负责人的需求,同时也将提高生物医学研究的整体能力
内华达大学里诺分校和内华达大学医学院。 Core C将完成以下具体任务
COBRE 第一阶段的目标: 具体目标 1:建立、维护和运营一个设施,提供
用于研究细胞的最先进的高空间和时间分辨率成像方法
健康和疾病中的结构、信号通路和功能。显微镜技术的最新进展
生产了一代商用仪器,使生物医学研究人员能够
以前所未有的空间和能力研究生物系统的结构和功能之间的关系
时间分辨率接近或低于衍射极限。这一具体目标的目标是使高空间和
时间分辨率成像可作为 COBRE 研究人员的核心设施。全面的核心
将实施管理计划,以有效维护该核心的基础设施并优先考虑访问
为 COBRE 调查人员提供的核心服务。具体目标 2:为调查人员提供使用建议和培训
新技术。培训用户操作 HSTRI 核心设备和适当的样品
准备工作以及对他们进行有关这些设施提供的科学可能性的教育是至关重要的一部分
最大化核心对生物医学研究的影响。核心人员将提供适当的培训和
用户的监督。具体目标 3:开发用户群和运营计划,以维持
长期的核心。将制定计划以在项目期间和结束后维持对核心的支持
通过使用费资助的期限。 HSTRI 核心服务也将向非 COBRE 研究人员提供
COBRE 调查人员未预留的时段内进行充值。 UNR Med 和许多资金充足的实验室
UNR 表示有兴趣将高分辨率成像方法纳入他们的研究和未来
拨款申请。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Normand Leblanc其他文献
Normand Leblanc的其他文献
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{{ truncateString('Normand Leblanc', 18)}}的其他基金
Properties of Clca Channels in Vascular Myocytes
血管肌细胞 Clca 通道的特性
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7839247 - 财政年份:2009
- 资助金额:
$ 20.4万 - 项目类别:
Properties of Clca Channels in Vascular Myocytes
血管肌细胞 Clca 通道的特性
- 批准号:
7245897 - 财政年份:2005
- 资助金额:
$ 20.4万 - 项目类别:
Properties of Clca Channels in Vascular Myocytes
血管肌细胞 Clca 通道的特性
- 批准号:
7079430 - 财政年份:2005
- 资助金额:
$ 20.4万 - 项目类别:
Properties of Clca Channels in Vascular Myocytes
血管肌细胞 Clca 通道的特性
- 批准号:
7637857 - 财政年份:2005
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$ 20.4万 - 项目类别:
Properties of Clca Channels in Vascular Myocytes
血管肌细胞 Clca 通道的特性
- 批准号:
7435283 - 财政年份:2005
- 资助金额:
$ 20.4万 - 项目类别:
Properties of Clca Channels in Vascular Myocytes
血管肌细胞 Clca 通道的特性
- 批准号:
6983085 - 财政年份:2005
- 资助金额:
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