PROJECT 13

项目13

• 批准号: 8337778
• 负责人: KATHARINA RIBBECK
• 金额: $ 21.76万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8337778
• 关键词: Accounting; Acquired Immunodeficiency Syndrome; Antibiotic Resistance; Bacterial Infections; Biodiversity; Biological Phenomena; Biology; Cells; Communities; Cystic Fibrosis; Disease; Ecosystem; Engineering; Environment; Evolution; Gene Expression; Gene Expression Alteration; Generations; Genetic Variation; Goals; Individual; Individual Differences; Malignant Neoplasms; Mutation; Mycoses; Noise; Organism; Pathway interactions; Pattern; Pharmaceutical Preparations; Phenotype; Play; Predisposition; Process; Proteins; Research; Role; Scientist; Social Behavior; Structure; Time; circadian pacemaker; pathogen; protein folding; research study; response; theories

This proposal focuses on the generation, control, and exploitation of diversity in biology. Genetic diversity drives the evolution of organisms, hinders cures of cystic fibrosis, AIDS and cancer, plays a crucial role in bacterial and fungal infections, and accounts for individual differences in susceptibility to disease agents and the responses to drugs. Non-.genetic diversity allows different cells to respond differently to the same environment, differences that can increase the infectivity of pathogens and their resistance to antibiotics. This team will use experiment and theory to study the origin and consequences of biological diversity over scales of size and time that range from the folding of individual proteins to the formation of new species. The core of the proposal is the group of Bauer fellows, young interdisciplinary scientists who come from a variety of backgrounds and interact to form a single collaborative community that nucleates interactions amongst a wide range of research groups.

该提案着重于生物学多样性的产生，控制和剥削。遗传多样性驱动了生物体的演变，阻碍囊性纤维化，艾滋病和癌症的治疗方法，在细菌和真菌感染中起着至关重要的作用，并说明了对疾病药物易感性的个体差异以及对药物的反应。非元化多样性使不同的细胞对相同环境的反应不同，差异可以增加病原体的感染性及其对抗生素的抗性。 该团队将使用实验和理论来研究生物多样性在大小和时间的起源和后果，范围从单个蛋白质的折叠到新物种的形成。该提案的核心是鲍尔研究员组，年轻的跨学科科学家来自各种背景，并互动以形成一个单一的协作社区，该社区对广泛的研究小组之间的相互作用有核。