Enhancing basic and translational TB research in northern Vietnam

加强越南北部的基础和转化结核病研究

• 批准号: 10115836
• 负责人: Brian Thacher Murphy
• 金额: $ 21.59万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10115836
• 关键词: AIDS/HIV problem; Academy; Antibiotics; Basic Science; Biochemistry; Biodiversity; Biological Assay; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chicago; Clinical; Collaborations; Complement; Country; Development; Disease; Drug resistance in tuberculosis; Epidemiology; Foundations; Funding; HIV Seropositivity; Hygiene; Illinois; In Vitro; Infrastructure; Institutes; Institution; Lead; Medical; Mycobacterium tuberculosis; Natural Resources; Pathogenicity; Pharmaceutical Preparations; Plants; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Science; Scientist; Students; System; Technology; Training; Training Programs; Training and Education; Translational Research; Tuberculosis; United States National Institutes of Health; Universities; Vietnam; Work; World Health Organization; base; post-doctoral training; pre-doctoral; programs; screening; screening program; success

In 2014, the World Health Organization estimated that there were 1.5 million deaths as a result of Mycobacterium tuberculosis (TB) infection (0.4 million of which were HIV-positive). Vietnam is located in a region that accounts for 58% of the world's TB cases, and an estimated 137,000 Vietnamese are infected with TB per year (5,000 of which acquire drug-resistant TB). Of these, the disease kills an estimated 19,000 Vietnamese annually. In the current proposal, we aim to enhance and strengthen a research training program between the University of Illinois at Chicago (UIC), the Institute of Marine Biochemistry at the Vietnam Academy of Science and Technology (IMBC-VAST), and the National Institute of Hygiene and Epidemiology (NIHE) in Hanoi, Vietnam. We aim to enhance host country basic and translational research capacity that focuses on the discovery and development of antibiotic leads for TB. Since the 1990s, the Centers for Disease Control and Prevention have invested heavily in both clinical labs and HIV/AIDS/TB surveillance systems in Vietnam, though these and several other efforts have focused predominantly on building medical infrastructure. Our proposal will bridge this gap by enhancing basic and translational science research infrastructure and a researcher training program that focuses on utilizing host-country resources to discover antibiotic leads that will treat TB and probe its basic mechanisms of pathogenicity through coordinated antibiotic lead screening programs in Hanoi. The success of this program is driven by short- and long-term research training and education. UIC has a strong track record of collaboration with VAST. Through NIH and MacArthur Foundation funding in the past 20 years, the team has worked to build a plant-based drug-lead discovery and resource conservation program. However, with greater than 3,000 km of coastline, Vietnam harbors some of the richest marine biodiversity in the world, from which this proposal aims to mine. The aims of this program are 1) Establish three independent investigators at IMBC-VAST/NIHE via long-term postdoctoral training at UIC; 2) Provide short- and long-term antibiotic-specific training to nine IMBC/NIHE predoctoral students over the course of the program period; 3) Enhance biological assay research infrastructure through creation of an in vitro M. tuberculosis screening program at NIHE. In a five-year period, our program will generate twelve highly trained scientists who specialize in TB antibiotic discovery and development. Three of the twelve scientists – with considerable institutional support from the Director and President of their respective institutes – will establish independent research groups that complement a broader program that uses Vietnam's natural resources to discover TB antibiotics, and to use these leads to explore mechanisms of M. tuberculosis pathogenicity. Beyond the five-year project period, the significant enhancement in research capacity at IMBC and NIHE will establish northern Vietnam as a translational screening center for TB, and will facilitate collaboration with institutions across and outside Vietnam.

2014年，世界卫生组织估计有150万人死于结核分枝杆菌（TB）感染（其中40万人为艾滋病毒阳性），越南所在地区的结核病病例占世界的58%。据估计，每年有 137,000 名越南人感染结核病（其中 5,000 人患有耐药结核病）。估计每年有 19,000 名越南人。在目前的提案中，我们的目标是加强和加强伊利诺伊大学芝加哥分校 (UIC) 与越南科学技术研究院海洋生物化学研究所 (IMBC-VAST) 之间的研究培训项目，我们的目标是加强东道国的基础和转化研究能力，重点关注结核病抗生素的发现和开发。 20 世纪 90 年代，疾病控制和预防中心在越南的临床实验室和艾滋病毒/艾滋病/结核病监测系统上投入了大量资金，尽管这些和其他几项努力主要集中在建设医疗基础设施上，我们的建议将通过加强基本设施来弥补这一差距。转化科学研究基础设施和研究人员培训计划，重点是利用东道国资源发现治疗结核病的抗生素先导物，并通过河内协调一致的抗生素先导物筛查项目探索其致病性的基本机制。该计划的成功得益于以下因素。短期和长期UIC 与 VAST 有着良好的合作记录，在过去 20 年中，通过 NIH 和麦克阿瑟基金会的资助，该团队一直致力于建立基于植物的药物先导物发现和资源保护计划。越南拥有超过 3,000 公里的海岸线，拥有世界上最丰富的海洋生物多样性，本提案旨在从中进行采矿 该计划的目标是 1) 通过 IMBC-VAST/NIHE 建立三名独立调查员。在 UIC 进行长期博士后培训； 2) 在项目期间为 9 名 IMBC/NIHE 博士生提供短期和长期抗生素特异性培训； 3) 通过创建体外 M 增强生物测定研究基础设施NIHE 的结核病筛查项目将在五年内培养出 12 名训练有素的科学家，他们专门从事结核病抗生素的发现和开发，这 12 名科学家中的 3 名得到了各自研究所主任和院长的大力支持。将要建立独立的研究小组，补充更广泛的计划，利用越南的自然资源发现结核病抗生素，并利用这些线索探索结核分枝杆菌的致病机制。 在五年项目期之后，IMBC 和的研究能力显着增强。 NIHE 将把越南北部建立为结核病转化筛查中心，并将促进与越南国内外机构的合作。

项目成果

Discovery of a New Antibiotic Demethoxytetronasin Using a Dual-Sided Agar Plate Assay (DAPA).

使用双面琼脂平板测定 (DAPA) 发现一种新型抗生素去甲氧基四氢呋喃。

• 发表时间: 2023-08-11
• 影响因子: 5.3
• 作者: Lee, Jung;Ma, Rui;Nguyen, Linh;Khan, Shahebraj;Qader, Mallique;Mpofu, Enock;Shetye, Gauri;Krull, Nyssa K;Augustinović, Mario;Omarsdottir, Sesselja;Cho, Sanghyun;Franzblau, Scott G;Murphy, Brian T
• 通讯作者: Murphy, Brian T

Discovery of new genetic determinants of morphological plasticity in rice roots and shoots under phosphate starvation using GWAS.

使用 GWAS 发现磷酸盐饥饿下水稻根和芽形态可塑性的新遗传决定因素。

• DOI: 10.1016/j.jplph.2020.153340
• 发表时间: 2020-12-15
• 期刊: Journal of plant physiology
• 影响因子: 4.3
• 作者: Nga T. T. Mai;C. D. Mai;H. Nguyen;Khang Quoc Le;Linh Viet Duong;T. Tran;H. To
• 通讯作者: H. To

Chemical Composition and Biological Activities of Metabolites from the Marine Fungi Penicillium sp. Isolated from Sediments of Co To Island, Vietnam.

海洋真菌青霉属代谢物的化学成分和生物活性。

• 发表时间: 2019-10-24
• 作者: Le, Hong Minh Thi;Do, Quynh Thi;Doan, Mai Huong Thi;Vu, Quyen Thi;Nguyen, Mai Anh;Vu, Thu Huyen Thi;Nguyen, Hai Dang;Duong, Nguyen Thi Thuy;Tran, Manh Hung;Chau, Van Minh;Pham, Van Cuong
• 通讯作者: Pham, Van Cuong

Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea.

来自海绵衍生链霉菌的抗菌薰衣草酰化黄酮类化合物。

• 发表时间: 2019-09-10
• 影响因子: 5.4
• 作者: Cao, Duc Danh;Trinh, Thi Thanh Van;Mai, Huong Doan Thi;Vu, Van Nam;Le, Hong Minh;Thi, Quyen Vu;Nguyen, Mai Anh;Duong, Thu Trang;Tran, Dang Thach;Chau, Van Minh;Ma, Rui;Shetye, Gauri;Cho, Sanghyun;Murphy, Brian T;Pham, Van Cuong
• 通讯作者: Pham, Van Cuong

Antimicrobial lavandulylated flavonoids from a sponge-derived actinomycete.

来自海绵来源的放线菌的抗菌薰衣草酰化黄酮类化合物。

• 发表时间: 2020-02
• 影响因子: 2.2
• 作者: Cao, Duc Danh;Do, Thi Quynh;Doan Thi Mai, Huong;Vu Thi, Quyen;Nguyen, Mai Anh;Le Thi, Hong Minh;Tran, Dang Thach;Chau, Van Minh;Cong Thung, Do;Pham, Van Cuong
• 通讯作者: Pham, Van Cuong