NATIONAL SWINE RESEARCH AND RESOURCE CENTER

国家猪研究和资源中心

• 批准号: 8356903
• 负责人: LELA K. RILEY
• 金额: $ 146.58万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356903
• 关键词: Address; Biomedical Research; Communities; Country; Cryopreservation; Detection; Development; Discipline; Disease; Educational Activities; Embryo; Engineering; Ensure; Family suidae; Funding; Future; Germ Cells; Goals; Grant; Health; Human; Knock-out; Maintenance; Methods; Modeling; Monitor; National Center for Research Resources; Prevention; Principal Investigator; Production; Reagent; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scientist; Site; Somatic Cell; Source; Tissues; Training; Training Activity; Transgenic Organisms; United States National Institutes of Health; animal resource; base; cost; experience; human disease; improved; innovation; microbial; pathogen; prevent; skills

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Significant progress is being made toward prevention and cures for many human diseases via swine-based research. Unfortunately, there are several major impediments to the realization of the full potential of pigs as models of human disease. The overall goal for this application is to establish a National Swine Research and Resource Center (NSRRC), which will address these major impediments. The proposed NSRRC will develop the infrastructure to ensure that biomedical investigators across a variety of disciplines have access to critically needed swine models of human health and disease. The NSRRC will also serve as a central resource for reagents, information and training related to swine models. An interdisciplinary team of scientists exists at the MU with experience in establishing and operating successful animal resource centers and each of the disciplines required to operate the NSRRC. No other place in the country possesses this array of skills and resources. The Specific Aims are: 1. To develop a National Swine Research and Resource Center. Functions of the NSRRC will include: (a) Importation of existing swine models of human health and disease, (b) rederivation of pigs to eliminate pathogens and health monitoring to assure maintenance of a pathogen-free status, (c) cryopreservation and storage of gametes, embryos and somatic cells to prevent future loss of valuable models, (d) distribution of high quality, pathogen-free pigs, and (e) creation of genetically-engineered pigs. 2. To perform innovative research that will benefit the NSRRC and the biomedical research community. Research projects are aimed at improving: a) the cryopreservation of pig reproductive cells and tissues; and b) the detection and elimination of microbial pathogens in pigs, reproductive cells and tissues; and c) development of improved methods for the production of transgenic and knockout pigs. The NSRRC will also serve as a site for training and educational activities related to research employing swine models.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 描述（由申请人提供）： 通过基于猪的研究，正在为预防和治愈许多人类疾病取得重大进展。不幸的是，实现猪作为人类疾病模型的全部潜力的主要障碍。该应用程序的总体目标是建立国家猪研究和资源中心（NSRRC），该中心将解决这些主要障碍。拟议的NSRRC将开发基础设施，以确保各种学科的生物医学研究人员可以使用人类健康和疾病的急需的猪模型。 NSRRC还将作为与猪模型有关的试剂，信息和培训的中心资源。一个跨学科的科学家团队存在于MU中，具有建立和运营成功的动物资源中心以及操作NSRRC所需的每个学科的经验。该国没有其他地方拥有一系列技能和资源。 具体目的是： 1。开发国家猪研究和资源中心。 NSRRC的功能将包括：（a）进口人类健康和疾病的现有猪模型，（b）猪的重新生动以消除病原体和健康监测，以确保维持无病原体状态的状态，（（c）对配子，胚胎和体现细胞的冷冻保存和存储，以防止有价值的模型和少量模型的分布，D），D），D），D），（d）质量，d的分布，D）遗传工程猪。 2。进行创新的研究，将使NSRRC和生物医学研究界受益。 研究项目旨在改善：a）猪生殖细胞和组织的冷冻保存； b）在猪，生殖细胞和组织中检测和消除微生物病原体； c）开发改进的转基因和基因敲除猪的方法。 NSRRC还将作为与猪模型研究有关的培训和教育活动的站点。