CHILDHOOD ABSENCE EPILEPSY: RX, PK-PD-PHARMACOGENETICS

儿童失神癫痫：RX、PK-PD-药物遗传学

• 批准号: 8167077
• 负责人: RAMAN SANKAR
• 金额: $ 0.73万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167077
• 关键词: Absence Epilepsy; Adverse effects; Antiepileptic Agents; Attention; Behavior; Child; Childhood; Clinical Trials Design; Cognition; Computer Retrieval of Information on Scientific Projects Database; Ethosuximide; Failure; Freedom; Funding; Grant; Institution; Pharmacogenetics; Quality of life; Research; Research Personnel; Resources; Risk; Seizures; Source; United States National Institutes of Health; Valproic Acid; lamotrigine; time use

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1a: To determine whether ethosuximide (ETX), lamotrigine (LTG) or valproic acid (VPA) is the most effective initial monotherapy for pediatric subjects with childhood absence epilepsy (CAE), defined as the antiepileptic drug (AED) with the greatest likelihood of seizure control and lowest risk of treatment limiting side effects over time, using a freedom from failure trial design. Specific Aim 1b: To define and contrast the effects of ETX, LTG, and VPA monotherapy on cognition (especially attention), behavior and quality of life in children with CAE.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 Specific Aim 1a: To determine whether ethosuximide (ETX), lamotrigine (LTG) or valproic acid (VPA) is the most effective initial monotherapy for pediatric subjects with childhood absence epilepsy (CAE), defined as the antiepileptic drug (AED) with the greatest likelihood of seizure control and lowest risk of treatment limiting side effects over time, using a freedom from failure trial design. 特定目的1B：定义和对比ETX，LTG和VPA单一疗法对认知（尤其是注意），CAE儿童生活质量的影响。