IMPACT OF OBESITY AND PHYSICAL ACTIVITY ON ENDOMETRIAL CANCER GENESIS

肥胖和体力活动对子宫内膜癌发生的影响

• 批准号: 8167169
• 负责人: SUSAN C MODESITT
• 金额: $ 2.41万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167169
• 关键词: Adipocytes; Affect; Androgens; Biological Markers; Blood; Body mass index; Breast; Cardiovascular Diseases; Collection; Colon Carcinoma; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diabetes Mellitus; Endometrial; Endometrial Carcinoma; Endometrium; Estrogens; Fatty acid glycerol esters; Funding; Goals; Grant; Health; Hormonal; Hysterectomy; Institution; Link; Malignant - descriptor; Malignant Neoplasms; Measures; Obesity; Overweight; Pancreas; Physical activity; Play; Population; Postmenopause; Process; Production; Prostate; Qualifying; Research; Research Personnel; Resources; Risk Factors; Role; Sampling; Source; United States; United States National Institutes of Health; Woman; prevent; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity in the United States is reaching epic proportions with 65% of the population being defined as overweight (body mass index-BMI>25) and 30% also qualifying as obese (BMI>30). Obesity is linked to numerous adverse health consequences including cardiovascular disease, diabetes and cancers of the colon, prostate, pancreas, breast and endometrium (uterine lining). Endometrial cancer is the fourth most common cancer in women in the United States and is expected to affect 40,000 women in 2005. Approximately 40% of endometrial cancer may be attributed to obesity and this is thought to be primarily due to the increased estrogen production in adipocytes (fat cells) through the conversion of androgens to estrogens. Yet not all obese women will develop endometrial cancer suggesting that other factors aside from the increased estrogen must also play a role in the process of malignant transformation. Protective factors in obese women include physical activity but the exact mechanisms that underlie such protection remain poorly understood. Little prospective data exist on adipocyte derived factors or physical activity levels in overweight and obese women. Therefore, the purpose of this study is prospectively collect baseline physical activity measures, baseline body mass index, baseline hormonal levels, blood/fat samples, and endometrial samples from overweight and obese postmenopausal women who are undergoing hysterectomy. After collection, we will explore and identify differences in either fat or blood biomarkers or in physical activity levels in women with and without endometrial cancer. The goal of this research is to better define risk factors in postmenopausal overweight and obese women that predispose to endometrial cancer and to identify any protective factors that correlate with physical activity. The ultimate goal of the research is to be able to predict, and perhaps to eventually prevent, the development of endometrial cancer in obese women.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 美国的肥胖症已达到史诗般的比例，其中65％的人口被定义为超重（体重指数-BMI> 25），而30％的人口也被定义为肥胖（BMI> 30）。 肥胖与许多不良健康后果有关，包括结肠，前列腺，胰腺，乳腺癌和子宫内膜（子宫内膜）的心血管疾病，糖尿病和癌症（子宫内膜）。 子宫内膜癌是美国女性第四大癌症，预计在2005年将影响40,000名妇女。子宫内膜癌的大约40％可能归因于肥胖症，这被认为主要是由于依从脂肪细胞（脂肪细胞）的雌激素产生的增加，这是由于雌激素对雌激素的转化而产生的。然而，并非所有肥胖女性都会患上子宫内膜癌，这表明除了增加雌激素外，其他因素还必须在恶性转化过程中发挥作用。 肥胖妇女的保护因素包​​括体育锻炼，但这种保护基础的确切机制仍然很少理解。 超重和肥胖女性中的脂肪细胞衍生因素或体育活动水平几乎没有前瞻性数据。因此，这项研究的目的是预期收集基线体育锻炼措施，基线体重指数，基线激素水平，血液/脂肪样本以及正在进行子宫切除术的绝经后妇女的子宫内膜样品。 收集后，我们将探索和确定患有和没有子宫内膜癌的女性的脂肪或血液生物标志物或体育活动水平的差异。 这项研究的目的是更好地定义绝经后超重和肥胖女性的危险因素，这些妇女容易产生子宫内膜癌并确定与体育锻炼相关的任何保护因素。该研究的最终目标是能够预测肥胖妇女的子宫内膜癌的发展，甚至最终预测。