VIRAL REPLICATION, CLEARANCE IN ASTHMATICS, NON-ASTHMATICS-RHINOVIRUS CHALLENGE

病毒复制、哮喘清除、非哮喘鼻病毒挑战

• 批准号: 8167171
• 负责人: PETER W HEYMANN
• 金额: $ 10.02万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167171
• 关键词: Allergic; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; IgE; Infection; Institution; Investigation; Research; Research Personnel; Resources; Respiratory System; Respiratory tract structure; Rhinovirus; Risk; Sequence Analysis; Source; Symptoms; Testing; Time; United States National Institutes of Health; Viral; airway inflammation; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This investigation will provide a time-sequence analysis of the response to rhinovirus following viral inoculation in asthmatic subjects who are sero-negative to the strain of rhinovirus causing the infection. The investigators will test the hypothesis that asthmatics have a greater risk for respiratory tract symptoms and airway inflammation triggered by infections with rhinovirus if they have high levels of total IgE ( 200 IU/ml). In addition, this study will test the hypothesis that viral replication will be increased and viral clearance impaired in these allergic asthmatic subjects compared to the controls.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究将在哮喘受试者中对鼻病毒的反应进行时间序列分析，这些受试者对引起感染的鼻病毒菌株具有血清阴性。 研究人员将检验以下假设：哮喘患者具有呼吸道症状和气道炎症的风险更大，如果鼻病毒的感染具有高水平的总IGE（200 IU/ML），则会引起呼吸道炎症。此外，这项研究将检验以下假设：与对照组相比，这些过敏性哮喘受试者将增加病毒复制并损害病毒清除率。