D1, AT1 RECEPTORS IN HUMAN HYPERTENSION: SODIUM SENSITIVITY OF BLOOD PRESSURE

人类高血压中的 D1、AT1 受体：血压的钠敏感性

• 批准号: 8167153
• 负责人: ROBERT MUNSON CAREY
• 金额: $ 1.6万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167153
• 关键词: Blood Pressure; Blood Tests; Computer Retrieval of Information on Scientific Projects Database; Diet; Dietary Sodium; Funding; Genes; Genetic; Genetic Screening; Genetic Variation; Grant; Human; Hypertension; Hypotension; Institution; Kidney; Measurement; Pattern; Randomized; Research; Research Personnel; Resources; Sodium; Sodium Chloride; Source; United States National Institutes of Health; Urine; Water; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if there is a relationship between salt sensitivity and genetic variations. Certain genetic patterns may result in a change in the ability of the kidney to get rid of dietary sodium, resulting in sodium and water retention and a subsequent rise in blood pressure. Genetic screening will be performed in up to 3000 people in order to identify those with certain gene profiles. Four hundred (400) of those screened will be invited to participate in two weeks of diets, one week of low salt and one week of high salt, in randomized order. Blood pressure measurements, urine and blood tests will be taken while subjects are on the two weeks of varied salt diets. A significant rise in blood pressure from low salt to high salt diets will indicate salt sensitivity.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是确定盐敏感性与遗传变异之间是否存在关系。 某些遗传模式可能会导致肾脏清除膳食钠的能力发生变化，导致钠和水潴留，从而导致血压升高。将对多达 3000 人进行基因筛查，以识别具有特定基因谱的人。四百 (400) 名接受筛查的人将被邀请以随机顺序参加两周的饮食，一周低盐饮食和一周高盐饮食。当受试者接受为期两周的不同盐饮食时，将进行血压测量、尿液和血液检查。从低盐饮食到高盐饮食血压显着升高表明盐敏感性。