IMPROVING METABOLIC PARAMETERS OF ANTIPSYCHOTIC CHILD TREATMENT (IMPACT)

改善抗精神病药物儿童治疗的代谢参数（影响）

• 批准号: 8167274
• 负责人: CHRISTOPH U CORRELL
• 金额: $ 0.64万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167274
• 关键词: 17 year old; Adolescent; Antipsychotic Agents; Child; Computer Retrieval of Information on Scientific Projects Database; Counseling; Funding; Generations; Grant; Hospitals; Institution; Life Style; Metabolic; Metformin; Patients; Randomized; Research; Research Personnel; Resources; Site; Source; United States National Institutes of Health; Weight Gain; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This five-year, three-site study, entitled "Improving Metabolic Parameters of Antipsychotic Child Treatment", will evaluate two different strategies for reducing excessive weight gain associated with antipsychotic treatment in children and adolescents (8-17 years old). Two hundred forty patients (80 at NS-LIJ Zucker Hillside Hospital) will be randomized to one of three groups; A) Continuation of baseline SGA (second generation antipsychotic) + healthy lifestyle counseling; B) Continuation of baseline SGA + healthy lifestyle counseling + Metformin; C) Staggered switch from baseline SGA to Ariprozole + healthy lifestyle counseling.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项为期五年的三个站点研究的标题为“改善抗精神病药儿童治疗的代谢参数”，将评估两种不同的策略，以减少儿童和青少年（8-17岁）的抗精神病药物治疗相关的过度体重增加。 240名患者（在NS-Lij Zucker Hillside Hospital的80名患者）将被随机分为三组之一； a）延续基线SGA（第二代抗精神病药） +健康的生活方式咨询； b）基线SGA +健康生活方式咨询 +二甲双胍的延续； c）从基线SGA到Ariprozole +健康生活方式咨询的交错切换。