Effects of electronic cigarette wattage setting on vascular harm

电子烟瓦数设置对血管伤害的影响

• 批准号: 10046156
• 负责人: Paul D Chantler
• 金额: $ 22.8万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10046156
• 关键词: Acute; Adolescent; Adult; Aerosols; Aorta; Biological; Blood Vessels; Cardiovascular Diseases; Cause of Death; Cerebrovascular Disorders; Cerebrum; Characteristics; Chemical Exposure; Chemicals; Chronic; Cigarette; Clinical; Data; Development; Devices; Disease; Electronic cigarette; Environment; Etiology; Exposure to; Female; Fetus; Foundations; Functional disorder; Generations; Goals; Guidelines; Health; Health Personnel; Human; Impairment; Inhalation; Knowledge; Laboratories; Life; Maternal Exposure; Medical; Memory; Neurocognitive; Neurocognitive Deficit; Outcome; Particle Size; Particulate Matter; Pregnancy; Public Health; Public Policy; Rattus; Regulation; Reporting; Resistance; Risk; Rodent; Smoking; Structure; Temperature; Testing; Tobacco Industry; Toxic effect; Toxicology; Vascular Diseases; Xenobiotics; adolescent offspring; arterial stiffness; base; carbonyl compound; cerebrovascular; consumer product; e-cigarette aerosols; e-cigarette cessation; electronic cigarette use; fetal; in utero; indexing; male; maternal vaping; middle cerebral artery; offspring; pre-clinical; preclinical study; smoking cessation; ultrafine particle; vaping

Emerging evidence indicates that electronic cigarettes (e-cigs) induced significant, and similar, harm to the blood vessel structure and function as that seen with smoking. Nevertheless, e-cigs are being aggressively publicized as a healthier alternative to smoking and suggested as a medical aid for smoking cessation by health care providers – even in the context of pregnancy. Given that cardiovascular disease (CVD) is the leading cause of death in the US (and worldwide), characterizing the toxicity and understanding the etiology of e-cig induced vascular dysfunction is critically important. The concern for maternal vaping and vascular health is also a significant issue, because, 1) the fetus is at a vulnerable period in life and 2) maternal inhalation of nearly any xenobiotic particulate matter is found to have adverse fetal/offspring developmental outcomes. Thus, there is a critical need for preclinical studies to examine the toxicity of vaping on vascular related outcomes. Current knowledge gaps relating to the toxicity potential of vaping include, 1) what effect does e-cig device settings (i.e. watts/temperature) have on toxicity potential relating to particle size and composition/concentration of chemical compounds generated; 2) what component(s) in the base solution contribute to development of vascular dysfunction; and 3) what are the long-term consequences of maternal vaping on offspring health and disease later in life? The goal of this proposal is to, 1) identify the relationship between the operating wattage/temperature of e-cigs on the particulate matter (PM) size distribution and chemical composition in association clinical/biological assessments of vascular function due to direct exposure (primary user) and indirect exposure (offspring health as consequence of maternal exposure during pregnancy). Our overarching hypothesis is that operating e-cig device at lower wattages/temperature increases the potential for vascular harm/impairment to user; and in the context of maternal vaping during pregnancy, will result in a hostile gestational environment that will lead to abnormal developmental programming that manifest as impaired cerebral vascular function and deficits in neurocognitive function compared to controls. Vascular toxicity effects will be determined by indices of arterial stiffness, vascular reactivity, and neurocognitive function, in relationship to altered physical-chemical exposures we generate. We expect our data will provide toxicological and clinical evidence to inform clinicians and consumers about vascular health concerns, and provide regulatory and federal agencies information needed in establishing public policy, guidelines or regulations.

新出现的证据表明，电子烟 (e-cigs) 对血液造成显着且类似的伤害 然而，电子烟的血管结构和功能却被大力宣传为吸烟。 更健康的吸烟替代品，并被医疗保健提供者建议作为戒烟的医疗辅助手段 – 即使在怀孕期间也是如此，因为心血管疾病 (CVD) 是导致死亡的主要原因。 美国（和世界各地），描述电子烟诱发血管的毒性并了解其病因学 对母亲电子烟和血管健康的关注也是一个重要问题。 因为，1) 胎儿正处于生命的脆弱时期，2) 母亲吸入了几乎所有的异生物质颗粒 已发现物质对胎儿/后代的发育结果产生不良影响，因此迫切需要。 检验电子烟对血管相关结果的毒性的临床前研究。 与电子烟潜在毒性相关的信息包括：1) 电子烟设备设置（即瓦特/温度）有何影响 具有与化合物的粒径和成分/浓度相关的潜在毒性 产生；2) 基础溶液中的哪些成分会导致血管功能障碍；以及 3) 母亲吸电子烟对后代的健康和以后的疾病有哪些长期影响？ 该建议的目的是，1) 确定电子烟的工作功率/温度之间的关系 颗粒物 (PM) 尺寸分布和化学成分与临床/生物学评估的关联 由于直接暴露（主要使用者）和间接暴露（后代健康）导致的血管功能的影响 我们的首要假设是在较低的温度下操作电子烟设备。 瓦数/温度会增加对使用者造成血管伤害/损害的可能性； 怀孕期间吸电子烟会导致妊娠环境恶劣，从而导致发育异常 表现为脑血管功能受损和神经认知功能缺陷的编程 与对照相比，血管毒性作用将由动脉僵硬度、血管指数确定。 反应性和神经认知功能，与我们产生的物理化学暴露有关。 期望我们的数据将提供毒理学和临床证据，以告知追随者和消费者有关血管的信息 健康问题，并提供制定公共政策所需的监管和联邦机构信息， 准则或规定。