Developmental Research Program

发展研究计划

• 批准号: 10044052
• 负责人: ULRIKE PETERS
• 金额: $ 7.3万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10044052
• 关键词: Advertising; Applications Grants; Area; Award; Collaborations; Colorectal Cancer; Communities; Development; Discipline; Early Diagnosis; Epidemiology; Evaluation; Faculty; Financial Support; Fostering; Funding; Goals; Grant; Guidelines; Infrastructure; Institution; Malignant Neoplasms; Manuscripts; Molecular Biology; Monitor; Morbidity - disease rate; Oral; Outcome; Pathology; Peer Review; Phase; Primary Prevention; Program Research Project Grants; Research; Research Personnel; Research Project Grants; Research Proposals; Sampling; Secondary Prevention; Structure; Therapeutic; Translational Research; United States National Institutes of Health; cancer health disparity; career; ethnic diversity; innovation; interest; medically underserved population; mortality; new technology; novel; outcome forecast; programs; racial and ethnic; research and development; success; survivorship; translational research program

Project Summary/Abstract of the Development Research Program The Developmental Research Program (DRP) will provide key support to develop novel translational early-phase Projects in the area of cancer disparities that, ultimately, will contribute to the reduction in the morbidity and mortality of cancer among medically underserved populations. In line with the overall goals of our Translational Research Program in Colorectal Cancer Disparities. The DRP will foster new collaborations between participating institutions and initiate collaborations with other SPOREs and Disparities P20’s. Additionally, our Career Enhancement Program (operated through our Administrative Core) will encourage early career investigators, particularly those from racially/ethnically diverse backgrounds, to apply to the DRP. Our goal is to fund Developmental Research Projects encompassing a range of translational cancer disparities research, including molecular biology, epidemiology (primary and secondary prevention), early detection, prognosis, therapeutics, and survivorship. To achieve this goal, we will identify promising translational cancer disparities Research Projects through broad solicitation (Aim 1). We will encourage early and senior investigators to collaborate across multiple disciplines. New ideas will be solicited on an annual basis by broadly advertising pilot funding and targeted engagement with promising faculty. Aim 2 will focus on rigorous and balanced scientific review of DRP proposals. We will convene an expert panel encompassing a broad range of scientific disciplines and also include participation from our Community Advisory Board. We will follow the National Institutes of Health SPORE guidelines for these reviews. In addition to financial support, funded DRP Projects will receive strong infrastructure support and access to biospecimens and expertise related to novel technologies through our Administrative and Biospecimen and Pathology Cores (Aim 3). With our generous institutional matching support we will award $100,000 of funding to DRP projects annually and anticipate that each year we will fund about 3 one-year projects. The progress of all DRP projects will be monitored regularly with respect to achieving their specific aims and milestones using clearly defined evaluation criteria (Aim 4). Of particular interest will be the potential of each project to advance to a full SPORE Project. We will also track long-term reportable outcomes of each project such as peer-reviewed manuscripts, oral presentations and grant funding.

发展研究计划的项目摘要/摘要 发展研究计划（DRP）将为开发新型转化药物提供关键支持 癌症差异领域的早期项目最终将有助于减少癌症差异 医疗服务不足人群的癌症发病率和死亡率符合总体目标。 我们的结直肠癌差异转化研究计划将促进新的合作。 参与机构之间的合作，并启动与其他 SPORE 和 Disparities P20 的合作。 此外，我们的职业提升计划（通过我们的行政核心运作）将鼓励 早期职业调查员，特别是来自不同种族/民族背景的调查员，向 DRP 提出申请。 我们的目标是资助涵盖一系列转化癌症差异的发展研究项目 研究，包括分子生物学、流行病学（一级和二级预防）、早期检测、 为了实现这一目标，我们将确定有希望的转化癌症。 通过广泛征集的差异研究项目（目标 1） 我们将鼓励早期和高级研究项目。 每年都会征求研究人员跨多个学科进行合作的新想法。 目标 2 将侧重于广泛的广告试点资金和有针对性的与有前途的教师的接触。 我们将召集一个涵盖广泛的专家小组，对 DRP 提案进行科学平衡的审查。 我们将关注一系列科学学科，并包括我们的社区咨询委员会的参与。 美国国立卫生研究院 SPORE 指南对这些审查除了提供财政支持外，还提供资助。 DRP 项目将获得强大的基础设施支持，并获得生物样本和相关专业知识 通过我们的管理、生物样本和病理学核心（目标 3）的新技术。 慷慨的机构匹配支持 我们每年将为 DRP 项目提供 100,000 美元的资金， 预计每年我们将资助大约3个为期一年的项目。所有DRP项目的进度将是。 使用明确定义的方法定期监控其具体目标和里程碑的实现情况 评估标准（目标 4）特别令人感兴趣的是每个项目晋级为完整 SPORE 的潜力。 我们还将跟踪每个项目的长期可报告成果，例如同行评审的手稿、 口头报告和拨款。