Inhibition of Malaria Chloroquine Resistance Transporters

疟疾氯喹耐药性转运蛋白的抑制

• 批准号: 8084905
• 负责人: GEOFFREY A CHANG
• 金额: $ 102.38万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-21 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8084905
• 关键词: Accelerated Phase; Acute; Africa; Antimalarials; Arts; Binding; Biological Assay; Biological Availability; Cells; Cessation of life; Chemicals; Chemistry; Child; Chloroquine; Chloroquine resistance; Cultured Cells; Data; Developing Countries; Development; Dose; Drug Delivery Systems; Drug Design; Drug Transport; Drug resistance; Enzymes; Essential Genes; Falciparum Malaria; Family; Goals; Health; Human; In Situ; In Vitro; Integral Membrane Protein; Laboratories; Libraries; Life; Life Cycle Stages; Malaria; Membrane Proteins; Molecular; Mutation; New Agents; Oligopeptides; Organism; Parasites; Performance; Pharmaceutical Chemistry; Pharmaceutical Preparations; Plasmodium falciparum; Play; Population; Production; Proteins; Research Personnel; Resistance; Resolution; Risk; Role; Screening procedure; Site; Southeastern Asia; Structure; Techniques; Testing; Therapeutic; Vacuole; base; cellular targeting; chemical synthesis; clinically relevant; combat; combinatorial; design; drug development; drug discovery; drug metabolism; experience; fighting; global health; high throughput screening; improved; in vivo; inhibitor/antagonist; innovation; killings; mutant; novel; novel therapeutics; pharmacophore; pre-clinical; preclinical evaluation; programs; quinoline; response; small molecule; structural biology; therapy resistant

项目成果

Resin-supported catalysts for CuAAC click reactions in aqueous or organic solvents.

用于水或有机溶剂中 CuAAC 点击反应的树脂负载催化剂。

• DOI: 10.1021/co300076k
• 发表时间: 2012
• 期刊: ACS combinatorial science
• 作者: Presolski,StanislavI;Mamidyala,SreemanK;Manzenrieder,Florian;Finn,MG
• 通讯作者: Finn,MG