A nanoparticle-based immunoprophylactic strategy that protects against a broad sp

一种基于纳米粒子的免疫预防策略，可防止广泛传播

• 批准号: 8083758
• 负责人: ALLEN G HARMSEN
• 金额: $ 106.92万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8083758
• 关键词: Address; Adjuvant; Adverse effects; Aerosols; Affect; Aftercare; Allergic Disease; Allergic inflammation; Antiviral Response; Asthma; Attenuated; Avian Influenza A Virus; B-Lymphocytes; Bacteria; Bronchus-Associated Lymphoid Tissue; CD4 Positive T Lymphocytes; CD8B1 gene; Cells; Characteristics; Development; Disease; Dose; Effectiveness; Engineering; Ferrets; Freeze Drying; Heat shock proteins; Histocompatibility Testing; Hour; Hypertrophy; Immune; Immune response; Immune system; Infection; Inflammation; Influenza; Interferons; Interleukin-10; Interleukin-6; Libraries; Lung; Mediating; Mediator of activation protein; Modeling; Modification; Murine pneumonia virus; Mus; Natural Immunity; Peptide Hydrolases; Pneumovirus; Preparation; Principal Investigator; Production; Proteins; Receptor Signaling; Resistance; SARS coronavirus; Signal Transduction; Structure; System; T-Lymphocyte; Testing; Time; Tissue Engineering; Tissues; Toxic effect; Vaccines; Viral; Viral Antigens; Virus; Virus Diseases; Virus-like particle; Work; adaptive immunity; airway hyperresponsiveness; base; efficacy testing; follow-up; influenzavirus; lymph nodes; nanoparticle; novel; pathogen; programs; research study; respiratory virus; response; type I interferon receptor; vaccine development; viral nanoparticle

项目成果

Biomimetic antigenic nanoparticles elicit controlled protective immune response to influenza.

• DOI: 10.1021/nn4006544
• 发表时间: 2013-04-23
• 期刊: ACS NANO
• 影响因子: 17.1
• 作者: Patterson, Dustin P.;Rynda-Apple, Agnieszka;Harmsen, Ann L.;Harmsen, Allen G.;Douglas, Trevor
• 通讯作者: Douglas, Trevor

Regulation of IFN-γ by IL-13 dictates susceptibility to secondary postinfluenza MRSA pneumonia.

• DOI: 10.1002/eji.201444582
• 发表时间: 2014-11
• 期刊: EUROPEAN JOURNAL OF IMMUNOLOGY
• 影响因子: 5.4
• 作者: Rynda-Apple, Agnieszka;Harmsen, Ann;Erickson, Anfin S.;Larson, Kyle;Morton, Rachelle V.;Richert, Laura E.;Harmsen, Allen G.
• 通讯作者: Harmsen, Allen G.