Metamorphosis and development of Plasmodium within liver cells

肝细胞内疟原虫的变态和发育

• 批准号: 8112143
• 负责人: Isabelle Coppens
• 金额: $ 41万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-02 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8112143
• 关键词: 1-Phosphatidylinositol 3-Kinase; Antimalarials; Area; Autolysis; Autophagocytosis; Autophagosome; Binding; Biogenesis; Biological Metamorphosis; Biology; Cell Nucleus; Cell membrane; Cell physiology; Cells; Complex; Cytoskeleton; Data; Development; Developmental Process; Digestion; Docking; Endoplasmic Reticulum; Environment; Erythrocytes; Event; Exocytosis; Generations; Genes; Giant Cells; Goals; Hepatocyte; Human; Infection; Intervention; Invaded; Knowledge; Liver; Lysosomes; Malaria; Mammalian Cell; Mammals; Membrane; Metabolism; Mitochondria; Mitotic; Modeling; Molecular; Morphology; Organelles; Parasite Control; Parasites; Parasitic Diseases; Pathology; Pathway interactions; Penetration; Phase; Plasmodium; Play; Process; Production; Proteins; Proteolysis; Research; Role; Shapes; Signal Transduction; Site; Sporozoites; Staging; Structure; System; Therapeutic Intervention; Ubiquitin Like Proteins; Vacuole; Vesicle; base; biological systems; human disease; in vivo; inhibitor/antagonist; interest; intrahepatic; mortality; new therapeutic target; novel strategies; prevent; prophylactic; public health relevance; residence; trafficking; vector mosquito

项目成果

Metamorphoses of malaria: the role of autophagy in parasite differentiation.

• DOI: 10.1042/bse0510127
• 发表时间: 2011
• 期刊: Essays in biochemistry
• 影响因子: 6.4
• 作者: Coppens I

Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation

• DOI: 10.4161/auto.25832
• 发表时间: 2013-10-01
• 期刊: AUTOPHAGY
• 影响因子: 13.3
• 作者: Tomlins, Andrew M.;Ben-Rached, Fathia;Langsley, Gordon
• 通讯作者: Langsley, Gordon

Chemoprophylaxis vaccination with a Plasmodium liver stage autophagy mutant affords enhanced and long-lasting protection.

• DOI: 10.1038/s41541-021-00360-1
• 发表时间: 2021-08-10
• 期刊: NPJ vaccines
• 影响因子: 9.2
• 作者: Sahu T;Gehrke EJ;Flores-Garcia Y;Mlambo G;Romano JD;Coppens I
• 通讯作者: Coppens I