Regulation of neutrophil function and inflammation by ADAM17 during infection

ADAM17 在感染过程中对中性粒细胞功能和炎症的调节

• 批准号: 8141692
• 负责人: BRUCE K WALCHECK
• 金额: $ 33.21万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-22 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141692
• 关键词: Adhesions; Affect; Animals; Apoptosis; Bacterial Infections; Biological; Biological Process; Caspase; Cell Adhesion Molecules; Cell Surface Proteins; Cells; Cessation of life; Clinical Research; Cytokine Receptors; Data; Distant; Drug Delivery Systems; Environment; Equilibrium; Escherichia coli; Event; Extravasation; Future; Genes; Goals; Gram-Negative Bacterial Infections; Host resistance; Human; Immune system; Immunology; Infection; Infiltration; Inflammation; Inflammatory; Inflammatory Response; Knockout Mice; Knowledge; L-Selectin; Leukocytes; Mediating; Membrane; Metalloproteases; Minnesota; Mitogen-Activated Protein Kinases; Modeling; Molecular; Mus; Neutrophil Activation; Neutrophil Infiltration; Organ; Pathogenesis; Peritonitis; Phagocytosis; Play; Process; Proteins; Proteolytic Processing; Receptor Signaling; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Resistance to infection; Role; Sepsis; Septicemia; Signal Transduction; Staging; Testing; Therapeutic; Time; Tissues; Translating; Universities; Work; bacterial resistance; base; chemokine; cytokine; data sharing; in vivo; insight; interest; macrophage; member; mouse model; neutrophil; novel; prevent; programs; public health relevance; receptor; response; tool

项目成果

ADAM17 cleaves CD16b (FcγRIIIb) in human neutrophils.

• DOI: 10.1016/j.bbamcr.2012.11.027
• 发表时间: 2013-03
• 期刊: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
• 影响因子: 5.1
• 作者: Wang, Yue;Wu, Jianming;Newton, Robert;Bahaie, Nooshin S.;Long, Chunmei;Walcheck, Bruce
• 通讯作者: Walcheck, Bruce