Expanding xenosurveillance capabilities in central America

扩大中美洲的异种监视能力

基本信息

批准号：
10041581
负责人：
Gregory David Ebel
金额：
$ 23.77万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-11 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10041581
关键词：
Ache Affect Africa Americas Anger Animals Bite Blood Blood capillaries Blood specimen Central America Child Clinical Data Clinical Medicine Communicable Diseases Communities Culicidae Data Detection Devices Disease Domestic Animals Ebola virus Emerging Communicable Diseases Enrollment Entomology Environment Epidemic Exanthema Fever Frequencies Guatemala Hate Health Home environment Hour Household Human Laboratories Laboratory Study Latin America Methodology Methods Middle East Middle East Respiratory Syndrome Coronavirus Midgut Mind Monitor Needles Pain Paper Pathogen detection Performance Pilot Projects Population Process Public Health Quantitative Reverse Transcriptase PCR RNA Reporting Resources Rural Sampling Site Spottings Symptoms Syndrome System Temperature Time Validation Venipunctures Venous blood sampling Veterinarians Veterinary Medicine Viral Visiting Nurse Work Yellow fever virus Zoonoses base burden of illness cohort design field study health economics innovation insight member minimally invasive multidisciplinary next generation sequencing pandemic disease pathogen prospective surveillance data syndromic surveillance tool transmission process virology

项目摘要

This proposal is for an R21, Expanding xenosurveillance capabilities in Central America. The project is a highly multidisciplinary effort that includes collaborators with expertise in virology, public health entomology, surveillance, and human clinical and veterinary medicine. Our study is based on the idea that mosquitoes can serve as surveillance tools because they are essentially autonomous blood sampling devices. Freshly fed mosquitoes are collected from within dwellings and blood is used for surveillance purposes. If successful, our work would have the impact of simplifying certain types of surveillance that require human blood because although most people hate it when they and their children are stuck with needles, they don’t seem to mind mosquitoes being removed from within their homes. In addition, our approach has the potential to make sampling from animals safer by vastly reducing the need for direct contact with fearful and angry animals that bite, kick, etc.. Aim 1 focuses on validating xenosurveillance through a direct comparison to human-based syndromic surveillance. Aim 2 is designed to maintain the scientific rigor of our work by obtaining quantitative estimates of the sensitivity of Cx. quinquefasciatus and Ae. aegypti for xenosurveillance. This proposal leverages significant prior work on xenosurveillance that has focused on An. gambiae in W. Africa, and an ongoing pilot study of xenosurveillance in rural Guatemala.

该提案针对 R21，扩大中美洲的异种监视能力，该项目是一个高度重视的项目。多学科的努力，包括具有病毒学、公共卫生昆虫学专业知识的合作者，监测、人类临床和兽医医学我们的研究基于蚊子可以的想法。作为监视工具，因为它们本质上是新鲜喂养的自主血液采样设备。从住宅内收集蚊子，并使用血液进行监测。如果成功，我们的研究人员将进行监测。这项工作将会简化某些需要人类血液的监测类型，因为尽管大多数人讨厌自己和孩子被针扎住，但他们似乎并不介意此外，我们的方法还有可能使蚊子从家中消失。通过大大减少与恐惧和愤怒的动物直接接触的需要，更安全地从动物中取样咬、踢等目标 1 侧重于通过与人类综合症的直接比较来验证异种监视目标 2 旨在通过获得定量估计来维持我们工作的科学研究。 Cx. quinquefasciatus 和 Aegypti 对异种监视的敏感性。该提案利用了先前针对冈比亚的异种监视的重要工作。非洲，以及危地马拉农村地区正在进行的异种监视试点研究。