The Role of Accumbens Rapid Dopamine Signaling in Sucrose and Cocaine Seeking

伏隔快速多巴胺信号传导在蔗糖和可卡因寻找中的作用

• 批准号: 8288457
• 负责人: Courtney Marie Cameron
• 金额: $ 2.99万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8288457
• 关键词: Abstinence; Address; Animals; Area; Behavior; Behavioral; Brain; Brain region; Cells; Cocaine; Communities; Cues; Data; Development; Disease; Dopamine; Drug Addiction; Drug Exposure; Drug usage; Environment; Exhibits; Extinction (Psychology); Food; Goals; Human; Individual; Interruption; Intravenous; Laboratories; Laboratory Research; Location; Measurement; Measures; Mediating; Motor output; Neurons; Neurotransmitters; Nucleus Accumbens; Organism; Output; Pattern; Performance; Pharmaceutical Preparations; Pharmacological Treatment; Phase; Positioning Attribute; Process; Property; Public Health; Rattus; Recording of previous events; Reinforcement Schedule; Relapse; Reporting; Research; Resolution; Rewards; Role; Scanning; Schedule; Self Administration; Self-Administered; Signal Transduction; Stimulus; Sucrose; System; Techniques; Testing; Time; Training; Water; Work; addiction; design; drug abstinence; drug of abuse; drug reward; drug seeking behavior; insight; motivational processes; neurochemistry; public health relevance; reinforcer; relating to nervous system; reward processing

DESCRIPTION (provided by applicant): Targeting behaviors to successfully obtain rewards is an essential aspect of survival. In order to execute goal-directed behaviors, organisms must integrate information about their environment into motivated actions. However, in humans, unnatural rewards such as drugs of abuse can often come to take the place of natural rewards, leading to aberrant motivational processing. The performance of these goal-directed behaviors likely involves the concerted activation of specific brain regions and neurotransmitter systems. The nucleus accumbens (NAc) and its dopaminergic inputs form a key brain circuit for processing the reinforcing aspects of both natural and drug rewards. This proposal seeks to examine neurochemical activity in the NAc during the execution of goal-directed behaviors. Fast-scan cyclic voltammetry (FSCV) will be employed to measure changes in sub-second dopamine release in the NAc during a self-administration task for both sucrose and cocaine. Additionally, FSCV will be used to examine alterations in dopamine signaling following abstinence from cocaine self-administration. The results of these studies will provide insight into the factors influencing neurochemical signaling during the pursuit of natural as well as drug rewards. PUBLIC HEALTH RELEVANCE: Drug addiction is a pervasive public health issue for both individuals and their communities. Often, addicts are able to abstain from drug use for extended periods of time, only to relapse after encountering environments or situations previously associated with drug taking. This proposal seeks to examine the neurochemical factors mediating drug seeking behaviors, with a specific emphasis on the role of drug abstinence, and, therefore, will provide key information for the development of pharmacological treatments for drug addiction in humans.

描述（申请人提供）：针对成功获得奖励的行为是生存的重要方面。为了执行目标指导的行为，生物体必须将有关环境的信息整合到动机行动中。但是，在人类中，不自然的奖励（例如滥用药物）通常会代替自然奖励，从而导致异常的动机处理。这些目标指导行为的性能可能涉及特定大脑区域和神经递质系统的一致激活。伏隔核（NAC）及其多巴胺能输入构成了一种关键的脑电路，用于处理天然和药物奖励的增强方面。该提案试图在执行目标指导行为期间检查NAC中的神经化学活动。将使用快速扫描的环状伏安法（FSCV）来测量蔗糖和可卡因的自我管理任务期间NAC中NAC中下秒多巴胺释放的变化。此外，FSCV将用于检查可卡因自我管理的戒酒后多巴胺信号传导的变化。这些研究的结果将洞悉影响自然和药物奖励期间神经化学信号传导的因素。 公共卫生相关性：吸毒成瘾是个人及其社区的普遍公共卫生问题。通常，瘾君子能够长时间戒毒，只能在遇到与药物服用相关的环境或情况后复发。该建议旨在检查介导药物寻求行为的神经化学因素，并特别强调戒毒的作用，因此将为人类药物成瘾的药理治疗发展提供关键信息。