Early Autism Risk Longitudinal Investigation (EARLI) Network

早期自闭症风险纵向调查 (EARLI) 网络

基本信息

批准号：
8073689
负责人：
Craig J Newschaffer
金额：
$ 0.58万
依托单位：
DREXEL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2010-09-17
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8073689
关键词：
ADRB2 gene Address Age-Months Agonist Antibodies Autistic Disorder Autoimmunity Award Behavioral Biological Markers Blood specimen California Candidate Disease Gene Catecholamines Child Clinical assessments Collection Complex Data Data Collection Data Coordinating Center Diagnosis Documentation Epigenetic Process Etiology Evaluation Exposure to First Pregnancy Trimester Gene Expression Genes Genetic Genetic Polymorphism Genotype Goals Grant Home environment House Dust Institutes Interview Investigation Laboratories Life Measurement Measures Mediating Medical Records Methods Methylation Mind Molecular Profiling Mothers Natural History Nature Neonatal Newborn Infant Observational Study Patient Self-Report Pattern Pediatric Hospitals Perinatal Perinatal Exposure Phenotype Philadelphia Polychlorinated Biphenyls Population Study Predisposition Pregnancy Protocols documentation Public Health Schools Reporting Research Research Design Research Personnel Risk Risk Factors Risk Marker Sample Size Sampling Series Siblings Site Stress Telephone Interviews Third Pregnancy Trimester Time Umbilical Cord Blood Universities Visit autism spectrum disorder autoreactivity behavior measurement brain tissue cohort design diaries disorder risk endophenotype epidemiologic data fetal follow-up gene environment interaction high risk in utero maternal serum pollutant proband programs prospective repository urinary

项目摘要

DESCRIPTION (provided by applicant): The Early Autism Risk Longitudinal Investigation (EARLI) Network will establish and prospectively follow a cohort of mothers of children with an autism spectrum disorder (ASD) at the start of a subsequent pregnancy (with select preconception data collection). This enriched-risk cohort will have the potential to serve as a study population for a variety of observational studies on the etiology and natural history of ASDs. The Network includes an Administrative Center at the Drexel University School of Public Health, a Data Coordinating Center at University of California Davis, a Central Laboratory and Repository at the Johns Hopkins School of Public Health, and four field sites: 1) Drexel University School of Public Health / Children's Hospital of Philadelphia; 2) University of California Davis / MIND Institute; 3) Johns Hopkins University School of Public Health / Kennedy Krieger Institute; and 4) Northern California Kaiser Permanente. The EARLI Network will implement a core epidemiologic data collection protocol focusing on: 1) prospective documentation of exogenous exposure during pregnancy and early life; 2) collection and banking of biologic samples during pregnancy and early-life, allowing measurement of exposure biomarkers, endogenous risk biomarkers, genotypes, and gene-expression profiles; and 3) follow-up of the newborn sibling through 36 months of age to gather data on ASD diagnoses, continuous ASD behavioral domains, and other potential behavioral endophenotypes. The goal is to have data on 1,000 siblings of ASD probands from fetal life through 36 months of age. This will allow sufficiently-powered estimation of associations among exposures and biomarkers measured during the pre-, peri-, and neonatal periods and ASD risk as well as candidate gene, gene-environment interaction, epigenetic, and maternally-mediated genetic effects. Full data collection in the target sample size will require additional five-years beyond the initial award period; however, by the end of the award the Network will have followed 875 pregnancies and completed 250 24-month follow-up visits. The attached application describes a plan for establishing the cohort and presents a set of exemplary specific aims to be partially addressed during the initial award period and more completely addressed once data collection is completed. Other types of specific aims that could be addressed through additional analyses of EARLI Network cohort data are highlighted.

描述（由申请人提供）：早期自闭症风险纵向调查（Earli）网络将在随后的怀孕开始时建立并前瞻性地关注患有自闭症谱系障碍（ASD）的儿童母亲（ASD）（ASD）（ASD）。这种丰富的风险队列将有可能作为有关ASD的病因和自然历史的各种观察性研究的研究人群。该网络包括Drexel大学公共卫生学院的行政中心，这是加利福尼亚大学戴维斯大学的数据协调中心，约翰·霍普金斯公共卫生学院的中央实验室和存储库，四个现场地点：1）德雷克塞尔公共卫生学院 /费城公共卫生学院 /费城儿童医院； 2）加利福尼亚大学戴维斯大学 /思维学院； 3）约翰·霍普金斯大学公共卫生学院 /肯尼迪·克里格学院； 4）北加州凯撒永久。 Earli网络将实施核心的流行病学数据收集方案，重点是：1）预期在怀孕和早期生命期间外源性暴露的前瞻性文件； 2）在怀孕和早期生命期间收集和储存生物样品，从而测量暴露生物标志物，内源性风险生物标志物，基因型和基因表达谱； 3）在36个月大的时间内对新生同胞的随访，以收集有关ASD诊断，连续的ASD行为领域和其他潜在行为末端表型的数据。目的是获取有关从胎儿生命到36个月大的1,000个ASD先证者兄弟姐妹的数据。这将允许对在前，周期和新生儿时期和ASD风险以及候选基因，基因 - 环境相互作用，表观遗传学以及产物介导的遗传效应的疫苗和ASD风险以及候选基因的暴露和生物标志物之间进行足够的驱动估计。目标样本量中的完整数据收集将需要超出初始奖励期之外的五年；但是，到奖项结束时，该网络将在875例怀孕后进行，并完成了250个24个月的随访。所附的应用程序描述了建立队列的计划，并提出了一组示例性的特定目标，要在初始裁决期间部分解决，并在数据收集完成后更加完整地解决。突出显示了通过对Earli网络队列数据的其他分析来解决的其他类型的特定目标。