Identification of neural indices of distress tolerance using fMRI

使用功能磁共振成像识别应激耐受性的神经指标

基本信息

批准号：
8112236
负责人：
Stacey B Daughters
金额：
$ 22.08万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8112236
关键词：
Abstinence Accounting Adult Affective Alcohol or Other Drugs use Amygdaloid structure Anterior Antisocial Personality Disorder Area Arousal Behavior assessment Behavioral Borderline Personality Disorder Bulimia Chronic Clinical Cocaine Cocaine Dependence Complex Corpus striatum structure DSM-IV Data Decision Making Development Distress Dropout Drug usage Drug user Emotional Emotional Stress Event Failure Frequencies Functional Magnetic Resonance Imaging Goals Human Illicit Drugs Incidence Individual Individual Differences Laboratories Limbic System Link Measures Mediating Negative Reinforcements Neurobiology Outcome Participant Patient Self-Report Phase Prefrontal Cortex Prevention program Procedures Process Prospective Studies Proxy Psychology Public Health Relapse Reporting Research Rest Risk Sampling Scientist Staging Stress Structure Substance Addiction Substance abuse problem Time Treatment outcome Work addiction affective neuroscience avoidance behavior base behavior measurement cognitive neuroscience computerized craving dependence relapse distress tolerance experience indexing innovation interest intervention program neuroadaptation neuromechanism non-drug novel relating to nervous system response reward circuitry smoking cessation substance abuse treatment theories

项目摘要

DESCRIPTION (provided by applicant): Evidence indicates that distress intolerance, or one's inability to persist in goal directed activity while experiencing affective distress, provides a behavioral proxy of avoidance of affective distress, and is indicative of the ability to remain abstinent and in treatment during the early stages of an abstinence attempt. Despite the utility of the behavioral measures of distress intolerance in identifying individuals at risk for poor substance use outcomes, this line of work has yet to be utilized in an assessment paradigm capable of identifying the neural processes associated with distress intolerance. Although previous studies have identified key neural structures implicated in the relapse process including prefrontal and limbic regions, none to date have integrated these areas in an assessment paradigm that captures one's ability to tolerate distress without engaging in avoidance behavior. The specific aims of this study will thus allow for the bridging of scientists within affective and cognitive neuroscience with clinical and behavioral psychology in the utilization of a well validated distress intolerance paradigm in fMRI to identify key neurobiological indices responsible for distress intolerance. The distress intolerance paradigm provides an empirically validated and innovative approach to this line of research because it (1) elicits real-time distress in the context of goal directed activity as opposed to recalling a previously distressing event or viewing distressing pictures, (2) has repeatedly demonstrated a relationship with a number of "real-world" substance abuse outcomes, and perhaps most importantly, (3) allows for the study of one's behavioral response to distress (i.e. quitting the task) during the experimental procedure. Specifically, the primary aims of the current application are to identify the neural processes associated with the avoidance of affective distress (i.e., distress intolerance) in a sample of 30 healthy non-drug using and 30 cocaine dependent adults entering residential substance abuse treatment (Total n = 60), and the influence of these neural processes in explaining the relationship between distress intolerance and cocaine dependence. PUBLIC HEALTH RELEVANCE: Distress intolerance (i.e., the avoidance of affective distress) is associated with increased rates of substance dependence, relapse to substance use, as well as incidence of DSM-IV borderline personality disorder, antisocial personality disorder, and bulimia nervosa. Thus, identifying the neural mechanisms underlying distress intolerance will aide in the development of appropriate prevention and intervention programs and therefore holds considerable public health significance. The primary aims of the current application are to identify the neural processes associated with distress intolerance in a sample of 30 healthy non-drug using and 30 cocaine dependent adults entering residential substance abuse treatment (total n = 60), as well as the influence of these neural processes on explaining the relationship between distress intolerance and cocaine dependence.

描述（由申请人提供）：证据表明，痛苦不耐受，或者一个人在经历情感困扰时无法坚持目标导向的活动，提供了避免情感困扰的行为代表，并表明在治疗期间保持禁欲和治疗的能力禁欲尝试的早期阶段。尽管痛苦不耐受的行为测量可用于识别有不良药物使用结果风险的个体，但这一工作尚未用于能够识别与痛苦不耐受相关的神经过程的评估范式中。尽管之前的研究已经确定了与复发过程有关的关键神经结构，包括前额叶和边缘区域，但迄今为止还没有一项研究将这些区域整合到一个评估范式中，以捕获一个人在不参与回避行为的情况下忍受痛苦的能力。因此，这项研究的具体目标是将情感和认知神经科学领域的科学家与临床和行为心理学联系起来，利用功能磁共振成像中经过充分验证的痛苦不耐受范式来确定导致痛苦不耐受的关键神经生物学指标。痛苦不容忍范式为这一研究领域提供了一种经过经验验证的创新方法，因为它（1）在目标导向的活动背景下引发实时痛苦，而不是回忆以前的痛苦事件或观看痛苦的图片，（2）反复证明了与许多“现实世界”药物滥用结果的关系，也许最重要的是，（3）允许研究实验过程中一个人对痛苦（即退出任务）的行为反应。具体来说，当前应用程序的主要目的是在 30 名健康非吸毒者和 30 名可卡因依赖成年人进入住宅药物滥用治疗样本中，确定与避免情感困扰（即痛苦不耐受）相关的神经过程（总计n = 60），以及这些神经过程在解释痛苦不耐受和可卡因依赖之间关系方面的影响。公共卫生相关性：痛苦不耐受（即避免情感困扰）与物质依赖率增加、物质使用复发以及 DSM-IV 边缘性人格障碍、反社会人格障碍和神经性贪食症的发生率相关。因此，确定痛苦不耐受背后的神经机制将有助于制定适当的预防和干预计划，因此具有相当大的公共卫生意义。当前应用程序的主要目的是确定 30 名健康的非吸毒者和 30 名进入住宅药物滥用治疗的可卡因依赖成年人样本（总共 n = 60）中与痛苦不耐受相关的神经过程，以及这些神经过程解释了痛苦不耐受和可卡因依赖之间的关系。