Adaptive optics parallel confocal scanning ophthalmoscope (AO-PCSO)

自适应光学平行共焦扫描检眼镜 (AO-PCSO)

• 批准号: 8179238
• 负责人: Yuhua Liang Zhang
• 金额: $ 19.65万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8179238
• 关键词: Accounting; Age related macular degeneration; Age-Years; Blindness; Bruch' s basal membrane structure; Cells; Cessation of life; Child; Clinical; Complex; Data Collection; Degenerative Disorder; Diagnosis; Disabled Persons; Disease; Disease Progression; Elderly; Eye; Eye Movements; Functional disorder; Fundus photography; Health; Human; Image; Knowledge; Lasers; Life; Morphologic artifacts; Ophthalmoscopes; Ophthalmoscopy; Optical Coherence Tomography; Participant; Pathologic Nystagmus; Persons; Photoreceptors; Principal Investigator; Research; Resolution; Retinal; Retinal Cone; Retinal Degeneration; Retinal Diseases; Sampling; Scanning; Secondary to; Speed; Staging; Structure; Structure of retinal pigment epithelium; Visual; adaptive optics; clinical practice; early onset; handicapping condition; imaging modality; improved; in vivo; instrument; patient oriented; photoreceptor degeneration; prevent; programs; retinal rods; sample fixation; success

DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is the leading cause of blindness in people 50 years of age or older in the developed world. The most prominent clinical and histological damage involves retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris; but it is the degeneration, dysfunction, and death of photoreceptors that accounts for the vision loss. Anatomical and functional studies have found that photoreceptor degeneration and loss occur before disease in the RPE/Bruch's membrane complex progresses to late AMD. Although the cone photoreceptor degeneration is secondary to rod death, it is the cone loss that causes major visual handicap. As such detecting early cone degeneration in a clinical setting is strategically critical to prevent vision loss. Cone inner segments become widened and misshapen during the degeneration; we hypothesize that enlargement and deformation of the parafoveal cones could be used as an early clinical sign for the diagnosis of AMD. Identifying these signs may be facilitated by high-resolution and high-fidelity retinal imaging. The cellular scale retinal image in the living human eye can only be achieved by adaptive optics (AO) assisted ophthalmoscopy. But current AO retinal imaging is hampered by insufficient image acquisition speed and inadequate image fidelity. In this application, we will develop a high- speed, high-resolution AO parallel confocal scanning ophthalmoscope (AO-PCSO) to facilitate diagnosis of AMD at an earlier stage. The instrument developed in this application is 'real-world' patient oriented. The AO-PCSO exceeds current AO retinal imaging modalities with significantly improved data collection efficiency and image fidelity. This application breaks the barrier to the study of AMD, seeking to shift current clinical practice paradigms from macro-scale to micro-scale by providing cellular diagnosis of retinal degenerative disease. The success of this research will significantly improve our ability to diagnose AMD at its onset and our knowledge of disease progression. High-speed image acquisition is a signature advance in confocal retinal imaging; it is not only important for imaging the elderly subjects but also equally important for studies involving children with early onset retinal disease. PUBLIC HEALTH RELEVANCE: Age-related macular degeneration (AMD) is the leading cause of blindness in people 50 years of age or older in the developed world. We will develop a high-speed, high-resolution retinal imager called adaptive optics parallel confocal scanning ophthalmoscope (AO-PCSO) to facilitate diagnosis of AMD at an earlier stage.

描述（由申请人提供）：与年龄相关的黄斑变性（AMD）是发达国家50岁以上人群失明的主要原因。最突出的临床和组织学损害涉及视网膜色素上皮（RPE），BRUCH的膜和绒毛膜毛皮。但是，是感光者的变性，功能障碍和死亡的原因是视力丧失。解剖学和功能研究发现，在RPE/BRUCH的膜复合物中，光感受器的变性和损失发生在疾病之前，发展为晚期AMD。尽管锥形感受器变性是杆死亡的继发的，但锥体损失导致主要的视觉障碍。因此，在临床环境中检测早期锥变性对于防止视力丧失至关重要。锥体内部段在变性过程中变宽和畸形。我们假设偏盘锥的扩大和变形可以用作诊断AMD的早期临床征兆。高分辨率和高保真视网膜成像可以促进这些迹象。 活着的人眼中的细胞尺度视网膜图像只能通过自适应光学（AO）辅助眼镜镜来实现。但是，当前的AO视网膜成像受到图像采集速度不足和图像保真度不足的阻碍。在此应用中，我们将开发高速，高分辨率的AO平行共聚焦扫描眼镜镜（AO-PCSO），以促进早期阶段的AMD诊断。 在本应用程序中开发的仪器是“现实世界”以患者为导向的。 AO-PCSO超过了当前的AO视网膜成像方式，具有显着提高数据收集效率和图像保真度。该应用打破了对AMD研究的障碍，试图通过提供视网膜退行性疾病的细胞诊断来将当前的临床实践范式从宏观尺度转移到微尺度。这项研究的成功将显着提高我们诊断AMD发作和疾病进展知识的能力。高速图像采集是共聚焦视网膜成像中的签名进展。这不仅对于成像老年受试者很重要，而且对于涉及早期视网膜疾病儿童的研究同样重要。 公共卫生相关性：与年龄相关的黄斑变性（AMD）是发达国家50岁以上人群失明的主要原因。我们将开发一个高速，高分辨率的视网膜成像仪，称为自适应光学光学扫描眼镜（AO-PCSO），以促进在较早阶段诊断AMD。