Beyond GWAS: the next 10 years of InterLymph

超越 GWAS：InterLymph 的未来 10 年

• 批准号: 8130430
• 负责人: Wendy Cozen
• 金额: $ 1.2万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-06 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8130430
• 关键词: Acquired Immunodeficiency Syndrome; Address; Africa; Agreement; Asia; Australia; Biological; British Columbia; California; Canada; Case-Control Studies; Characteristics; Classification; Clinical; Collaborations; Confusion; Country; Data; Denmark; Development; Environment; Environmental Risk Factor; Epidemic; Epidemiologic Studies; Epidemiologist; Epidemiology; Etiology; Europe; European; Finding by Cause; Follicular Lymphoma; Funding; Future; Genes; Genetic; Genetic Risk; Goals; Group Meetings; Heterogeneity; Hodgkin Disease; Incidence; Individual; Institutes; Institution; International; Investigation; Italy; Location; Lymphoma; Malignant Neoplasms; Maryland; Measurement; Medical center; Middle East; Multiple Myeloma; Neoplasms; New South Wales; New York; Non-Hodgkin' s Lymphoma; North America; Pathologic; Pattern; Policies; Population Heterogeneity; Prevention; Research Methodology; Research Personnel; Resources; Risk; Risk Factors; Sardinia; Scientist; Series; Serum; Site; South America; Students; Subgroup; Time; Travel; United States National Institutes of Health; Universities; Update; Work; base; clinically significant; follow-up; gene environment interaction; genome wide association study; insight; large cell Diffuse non-Hodgkin' s lymphoma; meetings; member; posters; professor; programs; working group

DESCRIPTION (provided by applicant): This is to be the 10th annual meeting of the International Lymphoma Epidemiology Consortium ("InterLymph"), an international group of epidemiologists, statisticians, geneticists, basic scientists, and clinicians collaborating to elucidate the causes of the several varieties of non- Hodgkin lymphoma and related neoplasms (Hodgkin lymphoma and multiple myeloma). These investigators convene to address the unknown causation and the substantial annual increase in incidence of non-Hodgkin lymphoma, and the confusion arising from the frequent changes in classification, the widespread non-recognition of clear etiologic differences between subgroups, the inadequacy of available exposure measurement, the constraints faced by individual investigators, and the need to pool results across international boundaries, both for statistical power and comprehensive coverage. Working subgroups address specific issues defined by clinical subgroup and etiologic hypotheses. Collaborative projects are reviewed and updated, findings exchanged, new collaborative studies developed and policies formulated. The program and theme of each meeting is developed by an organizing committee working with the meeting host, who is an investigator in one of the member studies, and who brings together pertinent local experts as outside speakers. The meeting site usually rotates between North America and the other member study locations. The 2011 meeting will be hosted by Professor Pierluigi Cocco from the University of Cagliari in Italy, and the program will be developed by the Chair of the Organizing Committee (Dr. Wendy Cozen, PI), along with other members of the Organizing Committee (Drs. Christine Skibola, Paolo Boffetta, and Henrik Hjalgrim). The theme is "Beyond GWAS: the next 10 years of InterLymph". We plan to review all completed genome-wide association study results, promote the development of new collaborative gene-environment, gene-gene, and environment-environment interactions, concentrating on subtype-specific results and potential translational issues. In addition to the working-group sessions, there will be a program of speakers, including key guest speakers, and poster sessions for junior investigators and students. Approximately 100 attendees are expected and will include investigators from 18 institutions with completed or ongoing epidemiologic studies of lymphoma on multiple continents with over 16,000 cases and 16,000 controls from four continents. PUBLIC HEALTH RELEVANCE: Non-Hodgkin lymphomas are a diverse group of malignancies with a common hematological origin but diverse biological, epidemiological, and clinical characteristics. Increasing in incidence over the past four or five decades at rates of 3-4% annually, even excluding the larger increase attributable the AIDS epidemic. These neoplasms therefore constitute a major cancer subgroup of obscure etiology and no current means of prevention. This will be the tenth meeting of an international group of investigators (the International Lymphoma Epidemiological Consortium ("InterLymph") convened to overcome the many difficulties of lymphoma investigation: frequent pathologic reclassification, multiple subtypes, difficult exposure classification, and diverse research methodologies. As the previous meetings of this group have been, this meeting will be a combination of idea exchange, with speakers, outside key speakers, and posters, and a series of working sessions of collaborating scientists, who have pooled resources to mount a collective attack on the ignorance concerning the causation of these malignancies with studies of known and suspected environmental causes, the genetic underpinnings, and the interactions between them.

描述（由申请人提供）：这将是国际淋巴瘤流行病学联盟（“ Interlmph”）的第10届年度会议，这是一个国际流行病学家，统计学家，遗传学家，基础科学家，基础科学家和临床医生，共同阐明非霍德氏菌和相关Neopgn lyopgn lyopgg lyopgg lasmplams（Hodgkin lymphlass and Myopgg lass）的原因（ These investigators convene to address the unknown causation and the substantial annual increase in incidence of non-Hodgkin lymphoma, and the confusion arising from the frequent changes in classification, the widespread non-recognition of clear etiologic differences between subgroups, the inadequacy of available exposure measurement, the constraints faced by individual investigators, and the need to pool results across international boundaries, both for statistical power and comprehensive覆盖范围。工作子组解决了由临床亚组和病因学假设定义的特定问题。审查和更新协作项目，开发的调查结果，开发了新的合作研究以及制定的政策。每次会议的计划和主题是由与会议主持人合作的组织委员会成立的，该委员会是其中一项会员研究的调查员，并将相关的当地专家汇集为外部演讲者。会议地点通常在北美和其他成员研究地点之间旋转。 2011年的会议将由意大利Cagliari大学的Pierluigi Cocco教授主持，该计划将由组织委员会主席（Wendy Cozen，PI）以及组织委员会的其他成员（Christine Skibola，Paolo Boffetta，Paolo Boffetta和Henrik Hjalik Hjalgrim）开发。主题是“超越GWAS：Interlymph的接下来的10年”。我们计划回顾所有完整的全基因组关联研究结果，促进新的协作基因环境，基因基因和环境环境的相互作用的发展，集中在亚型特异性结果和潜在的翻译问题上。除了工作组会议外，还将有一系列演讲者计划，包括主要的演讲嘉宾，以及针对初级调查员和学生的海报会议。预计将有大约100名参与者，并将包括来自18个机构的调查人员，该机构对多大洲的淋巴瘤进行了完整或正在进行的流行病学研究，其中有16,000多个病例和16,000例来自四大洲的对照。 公共卫生相关性：非霍奇金淋巴瘤是一群具有共同血液学起源的恶性肿瘤，但生物学，流行病学和临床特征多样化。在过去的四到五年中，每年以3-4％的速度增加发病率，甚至不包括艾滋病流行的较大增加。因此，这些肿瘤构成了晦涩的病因的主要癌症亚组，没有当前的预防手段。 This will be the tenth meeting of an international group of investigators (the International Lymphoma Epidemiological Consortium ("InterLymph") convened to overcome the many difficulties of lymphoma investigation: frequent pathologic reclassification, multiple subtypes, difficult exposure classification, and diverse research methodologies. As the previous meetings of this group have been, this meeting will be a combination of idea exchange, with speakers, outside key speakers, and posters,以及一系列合作的科学家会议，他们汇总了对这些恶性肿瘤的无知进行集体攻击，并研究了已知和可疑的环境原因，遗传基础以及它们之间的相互作用。