2011 Nucleosides, Nucleotides, and Oligonucleotides GRC

2011 核苷、核苷酸和寡核苷酸 GRC

基本信息

批准号：
8116777
负责人：
WILLIAM B PARKER
金额：
$ 0.35万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-06-14 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8116777
关键词：
Acquired Immunodeficiency Syndrome Address Antineoplastic Agents Antiviral Agents Area Biochemistry Biological Biological Process Biology Catalytic RNA Cellular Metabolic Process Chemistry Collaborations Complement DNA Development Diagnosis Discipline Disease Enzyme Inhibition Epigenetic Process Future Gene Expression Genetic Transcription Goals Health Hematologic Neoplasms Knowledge Lead Learning Life MicroRNAs Minority New Agents Nobel Prize Nucleosides Nucleotides Ointments Oligonucleotides Oral Participant Pharmaceutical Preparations Process RNA Request for Proposals Research Research Personnel Scientist Series Small Interfering RNA Solid Neoplasm Structure Students System Technology Therapeutic Agents Universities Virus Diseases Woman Work cancer therapy disease diagnosis drug development effective therapy lecture notes meetings novel therapeutics nucleic acid analog nucleic acid metabolism nucleoside analog nucleotide receptor outcome forecast posters programs symposium synthetic biology tool

项目摘要

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on Nucleosides, Nucleotides, and Oligonucleotides as a part of the Gordon Research Conference series to be held in Salve Regina University, Newport, RI from July 3 - 8, 2011. The broad and long term goal of the conference is to increase our understanding of the chemistry of nucleosides, nucleotides, and oligonucleotides. The biological significance of these agents as tools for diagnosis and as drugs for treatment of life-threatening diseases will complement the chemistry as well as their use in understanding biological processes. The specific aims of this meeting will be to convene nine discussion leaders to moderate nine sessions. Chair and vice-chair of the conference will supervise the whole conference. There will be 21 speakers who will represent critical areas of the chemistry and biology of nucleosides, nucleotides, and oligonucleotides and 10 oral student presentations. The program will have a keynote address and eight sessions that broadly address current issues in synthetic biology, systems chemistry, DNA and RNA structures, transcription control of gene expression, nucleoside analogues as therapeutic agents, nucleotide receptors, catalytic RNA and epigenetics. The key note lecture will be given by J Szostack (Nobel Prize, 2009). In addition, two evening poster sessions will permit all participants to contribute to these topics. The meeting will provide numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. The significance of this application is that the Gordon Research Conference is the only platform where chemists and biologists who focus on nucleosides, nucleotides, and oligonucleotides come together. Nucleoside analogs, acting by diverse mechanisms, are highly effective for treatment of solid tumor and hematological malignancies and several viral diseases including AIDS. Nucleic acids analogs as siRNA, miRNA, antisense, catalytic RNA belong to the most exciting new areas in drug development. This conference is therefore highly significant regarding its health relatedness. The discussions among chemists and scientists will generate new knowledge and avenues for development of novel therapeutics. Besides becoming major tools for prognosis and diagnosis of diseases, oligonucleotides are widely used as new tools in epigenetics, synthetic biology and systems chemistry, which will become important technologies for generating new drugs for the future. The conference will focus on all these new areas and will be a discussion forum and an exchange platform for generating new knowledge and collaborations. PUBLIC HEALTH RELEVANCE: There are numerous anticancer and antiviral drugs that work by inhibition of enzymes involved in nucleic acid metabolism. The goal of the Nucleoside, Nucleotide & Oligonucleotide Gordon Research conference is to aid investigators learn about the newest developments in this field. There will be numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. This conference will promote an enhanced understanding of an important cellular metabolic process and lead to collaborations amongst scientists of various disciplines that could lead to future drug development.

描述（由申请人提供）：本提案请求对核苷、核苷酸和寡核苷酸会议提供部分支持，作为戈登研究会议系列的一部分，该会议将于 2011 年 7 月 3 日至 8 日在罗德岛州纽波特萨尔维里贾纳大学举行。会议的广泛和长期目标是增加我们对核苷、核苷酸和寡核苷酸化学的理解。这些试剂作为诊断工具和治疗危及生命的疾病的药物的生物学意义将补充化学及其在理解生物过程中的用途。本次会议的具体目标是召集九位讨论领袖主持九场会议。会议主席和副主席将监督整个会议。将有 21 名代表核苷、核苷酸和寡核苷酸化学和生物学关键领域的演讲者以及 10 名学生口头报告。该计划将有一个主题演讲和八场会议，广泛讨论合成生物学、系统化学、DNA和RNA结构、基因表达的转录控制、作为治疗剂的核苷类似物、核苷酸受体、催化RNA和表观遗传学中的当前问题。主旨演讲将由 J Szostack（2009 年诺贝尔奖获得者）主讲。此外，两次晚间海报会议将允许所有参与者为这些主题做出贡献。此次会议将为年轻研究人员、女性和少数族裔提供大量与该领域高级领导人互动的机会。该应用的意义在于，戈登研究会议是专注于核苷、核苷酸和寡核苷酸的化学家和生物学家聚集在一起的唯一平台。核苷类似物通过多种机制发挥作用，对于治疗实体瘤、血液恶性肿瘤以及包括艾滋病在内的多种病毒性疾病非常有效。 siRNA、miRNA、反义、催化RNA等核酸类似物属于药物开发中最令人兴奋的新领域。因此，本次会议就其健康相关性而言具有非常重要的意义。化学家和科学家之间的讨论将为开发新疗法产生新知识和途径。寡核苷酸除了成为疾病预后和诊断的主要工具外，还广泛用作表观遗传学、合成生物学和系统化学的新工具，这将成为未来生成新药的重要技术。会议将重点关注所有这些新领域，并将成为产生新知识和合作的讨论论坛和交流平台。公共健康相关性：有许多抗癌和抗病毒药物通过抑制核酸代谢中涉及的酶来发挥作用。核苷、核苷酸和寡核苷酸戈登研究会议的目标是帮助研究人员了解该领域的最新进展。年轻研究人员、女性和少数族裔将有大量机会与该领域的高级领导者互动。这次会议将促进加深对重要细胞代谢过程的理解，并促进不同学科的科学家之间的合作，从而促进未来的药物开发。