Structure and Energetics in Mammalian Cells

哺乳动物细胞的结构和能量学

• 批准号: 8205361
• 负责人: Joannes B Hoek
• 金额: $ 0.7万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8205361
• 关键词: Area; Award; Biochemical; Cell physiology; Collaborations; Development; Disadvantaged; Disease; Energy Metabolism; Event; Funding; Genes; Goals; Great Britain; Individual; International; Knowledge; Malignant Neoplasms; Mammalian Cell; Metabolic; Minority; Pathway interactions; Phenotype; Process; Request for Applications; Research; Research Personnel; Role; Scientist; Societies; Specialist; Structure; Structure-Activity Relationship; Subcellular structure; System; Systems Biology; Travel; Woman; anticancer research; base; cancer cell; career; disability; improved; innovation; interest; knowledge base; neoplastic cell; novel; symposium; tumor

DESCRIPTION (provided by applicant): This application requests funding for travel awards to US-based scientists to attend a conference on the Systems Biology of Structures and Energetics in Mammalian Cells, with a focus on understanding the structural and functional basis for the transitions in integrated cell functions that characterize the development of tumors. Recent years have witnessed a remarkable surge in the recognition of the critical role of energy metabolism as a central constituent of the cancer phenotype. In addition, cancer cells involve major transitions in structure-function relationships that indicate a fundamental re-ordering of the integrated cell function. Although there are major gaps in our understanding of the relationships that drive these and related transitions, much of the detailed knowledge of the subcellular structural events and their energetic and metabolic implications resides with investigators who are not intimately involved in the disease-focused research. Based on these considerations, an international conference will be organized in Manchester, UK, under the auspices of the Biochemical Society of Great Britain, which will bring together investigators who are experts on the structural and energetic aspects of cellular function with systems biology researchers who have a major orientation on integrated cell function and with cancer researchers who can put these perspectives in a disease context. The conference format aims at an innovative approach to enhance discussion and promote interactions and collaborations between investigators from very different backgrounds and knowledge bases, to facilitate and promote their contribution to the understanding of changes in integrative cell function that leads to cancer. This application is to request travel awards for US-based investigators to participate in this conference. Applications will be encouraged from established investigators from diverse areas of research who can bring different perspectives to the discussion, as well as from early career investigators who are willing to break through existing paradigms and open new vistas on the problem of integrating cell function in disease. Particular emphasis will be placed on facilitating the participation of women scientists and encouraging the participation of researchers from disadvantaged minorities as well as investigators with disabilities. PUBLIC HEALTH RELEVANCE: There is much evidence that the transition to the cancer phenotype cannot be adequately described by the deregulation of individual genes or pathways, but requires an understanding of integrated cell function. The conference on Systems Biology of Structures and Energetics in Mammalian Cells aims at bringing together scientists who are specialists in structural and functional aspects of cell function and systems biologist interested in integrative cell function with cancer researchers who understand the disease process. The application requests funding for travel awards to encourage participation of US-based scientists to participate in and contribute to this conference, which is expected to bring novel perspectives to the field of cancer research that may contribute to the development of improved therapies.

描述（由申请人提供）：本申请要求为基于美国的科学家提供旅行奖励的资金，以参加哺乳动物细胞中结构和能量学系统生物学的会议，重点是了解综合细胞函数中特征表征肿瘤发育的综合细胞功能的结构和功能基础。近年来，人们认识到能源代谢作为癌症表型的主要成分的关键作用的巨大激增。此外，癌细胞涉及结构功能关系的主要过渡，这表明对综合细胞功能的基本重新排序。尽管我们对驱动这些和相关过渡的关系的理解存在重大差距，但对亚细胞结构事件的许多详细知识及其能量和代谢的意义都与与以疾病为中心的研究无关紧要的研究人员存在。基于这些考虑，将在英国曼彻斯特举行国际会议，在大不列颠的生物化学学会的主持下，该会议将召集研究人员，这些调查人员是针对细胞功能的结构和充满活力的专家，与系统生物学研究人员与在整合细胞功能上具有重大方向化的系统生物学研究人员，并与癌症研究者具有主要的疾病，可以在这些疾病中进行这些疾病的观点。会议格式旨在一种创新的方法，以增强与来自不同背景和知识基础的研究人员之间的互动和协作，以促进和促进其对导致癌症综合细胞功能变化的理解的理解的贡献。该申请旨在向美国调查人员申请旅行奖，以参加本次会议。从不同研究领域的既定调查员都会鼓励申请，他们可以为讨论带来不同的观点，以及愿意突破现有范式并开放有关将细胞功能整合在疾病中的问题的新远景的早期职业研究者。特别强调将促进女性科学家的参与，并鼓励来自处境不利的少数民族以及残疾研究人员的研究人员的参与。 公共卫生相关性：有很多证据表明，向癌症表型的过渡不能通过通过单个基因或途径的放松来充分描述，而需要了解综合细胞功能。哺乳动物细胞中结构和能量学系统生物学会议旨在将细胞功能的结构和功能方面的专家汇集在一起​​，以及与了解疾病过程的癌症研究人员感兴趣的综合细胞功能的生物学家。该申请要求提供旅行奖的资金，以鼓励美国科学家参与并为这次会议做出贡献，这有望将新颖的观点带入癌症研究领域，这可能有助于改善疗法的发展。