The Sixth International Mdm2 Workshop

第六届国际Mdm2研讨会

• 批准号: 8257339
• 负责人: James J Manfredi
• 金额: $ 0.45万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-19 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8257339
• 关键词: Academy; Address; Area; Award; Binding; Biology; Cancer Center; Collaborations; Complement; Doctor of Medicine; Doctor of Philosophy; Educational workshop; Embryonic Development; Ensure; Event; Family member; Funding; Gene Amplification; Goals; Human; Individual; International; Knowledge; Malignant Neoplasms; Mentors; Minority; Missense Mutation; New York; Oncogene Proteins; Pathway interactions; Philadelphia; Play; Protein p53; Reagent; Recruitment Activity; Reporting; Research; Research Personnel; Role; Science; Scientist; Senior Scientist; Site; Staging; Students; TP53 gene; Time; Translating; Travel; Tumor Suppressor Proteins; Underrepresented Minority; Universities; Woman; Writing; abstracting; career; graduate student; human disease; in vivo; medical schools; meetings; member; mouse model; overexpression; posters; social; symposium; tumor; ubiquitin-protein ligase

DESCRIPTION (provided by applicant): The p53 protein has been well-characterized as playing a tumor suppressor role in human cancer. Indeed, a majority of human tumors have sustained missense mutation in the TP53 gene. Mdm2 is a negative regulator of p53 that has been shown to act by inhibiting the transcriptional activity of p53 via direct binding as well as serving as an E3 ubiquitin ligase to target p53 for degradation. Consistent with such findings, Mdm2 has been implicated as also playing a role in human tumors with its overexpression or gene amplification being observed in a variety of cancers. A p53 Workshop is held every two years to bring together the p53 field in order to report on the latest research and to facilitate collaboration and exchange of reagents. In 2010, the 15th International p53 Workshop was held in Philadelphia, PA. Twelve years ago, a complementing Mdm2 Workshop was organized to be held in alternating years with the p53 conference. The sixth such workshop is to be held in New York, NY in October, 2011. The meeting is being co-organized by Drs. Carol Prives (Columbia University) and James J. Manfredi (Mount Sinai School of Medicine). The site of the conference is at the New York Academy of Sciences in downtown Manhattan. The New York Academy of Sciences is an established meeting facility. In this application, funds are being requested to support three important specific aims. The first aim is to facilitate the attendance of graduate students and postdoctoral researchers at the Sixth International Mdm2 Workshop and enhance their ability to interact with leaders in the field. The second aim is to ensure the attendance and participation of women and underrepresented minorities as invited speakers at the Workshop. This will be accomplished by the participation of two invited speakers who are both women and underrepresented minorities. The third aim is to enhance the attendance and participation of graduate students, postdoctoral researchers, and early-stage investigators who are from underrepresented groups including women and minorities. The goals of the three aims will largely be accomplished through the judicious use of travel awards. The International Mdm2 Workshop continues to be a unique venue in which researchers in the field of Mdm2 research can come together to share recent findings, facilitate collaborations, and enhance exchange of reagents. This stimulates scientific research by ensuring that Mdm2 investigators are aware of the most current research in this significant area. In so doing, duplicate efforts can be avoided, pitfalls can be shared, and knowledge in the field can move forward as rapidly as possible. PUBLIC HEALTH RELEVANCE: The p53 tumor suppressor and its negative regulator the Mdm2 oncoprotein have been clearly shown to play significant roles in a wide variety of human cancers. The Sixth International Mdm2 Workshop will ensure that research in this important field is accelerated and translated to have impact on human disease.

描述（由申请人提供）：p53 蛋白已被充分表征为在人类癌症中发挥肿瘤抑制作用。事实上，大多数人类肿瘤的 TP53 基因都存在持续错义突变。 Mdm2 是 p53 的负调节因子，已被证明通过直接结合抑制 p53 的转录活性以及充当 E3 泛素连接酶来靶向 p53 进行降解。与这些发现一致的是，Mdm2 也被认为在人类肿瘤中发挥着作用，在多种癌症中观察到其过度表达或基因扩增。 p53研讨会每两年举办一次，将p53领域聚集在一起，报告最新研究并促进试剂的合作和交流。 2010年，第15届国际p53研讨会在宾夕法尼亚州费城举行。十二年前，组织了一个补充性的 Mdm2 研讨会，与 p53 会议交替举行。第六次此类研讨会将于 2011 年 10 月在纽约州纽约市举行。该会议由 Drs. 共同组织。卡罗尔·普里夫斯（哥伦比亚大学）和詹姆斯·J·曼弗雷迪（西奈山医学院）。会议地点位于曼哈顿市中心的纽约科学院。纽约科学院是一个成熟的会议设施。在此申请中，请求资金来支持三个重要的具体目标。第一个目标是促进研究生和博士后研究人员参加第六届国际Mdm2研讨会，并增强他们与该领域领导者互动的能力。第二个目标是确保妇女和代表性不足的少数群体作为受邀发言人出席和参与研讨会。这将通过两名受邀演讲者的参与来完成，他们都是女性和代表性不足的少数族裔。第三个目标是提高来自女性和少数族裔等代表性不足群体的研究生、博士后研究人员和早期研究人员的出勤和参与。这三个目标将在很大程度上通过明智地使用旅行奖励来实现。国际 Mdm2 研讨会仍然是 Mdm2 研究领域的研究人员可以聚集在一起分享最新发现、促进合作并加强试剂交流的独特场所。这通过确保 Mdm2 研究人员了解这一重要领域的最新研究来刺激科学研究。这样做可以避免重复的工作，可以共享陷阱，并且可以尽快推进该领域的知识。 公共健康相关性：p53 肿瘤抑制因子及其负调节因子 Mdm2 癌蛋白已被明确证明在多种人类癌症中发挥重要作用。第六届国际 Mdm2 研讨会将确保这一重要领域的研究加速并转化为对人类疾病产生影响。