Dietary Patterns, Diet Quality + Cancer Risk

饮食模式、饮食质量癌症风险

• 批准号: 8132995
• 负责人: Frank B Hu
• 金额: $ 31.9万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132995
• 关键词: Accounting; Address; Adherence; Affect; American; Animals; Biochemical; Biochemical Markers; Biological; Biological Markers; Breast Cancer Risk Factor; C-Peptide; Cancer Patient; Carbohydrates; Cause of Death; Cessation of life; Cohort Studies; Colon Carcinoma; Colorectal Cancer; Data; Descending colon; Diagnostic; Diagnostic Neoplasm Staging; Diet; Dietary Factors; Dietary Practices; Eating; Epidemiology; Estrogen Receptors; Factor Analysis; Fasting; Food; Frequencies; Funding; Gonadal Steroid Hormones; Grant; Guidelines; Health; Health Professional; Incidence; Insulin; Insulin Resistance; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Intake; Location; Macronutrients Nutrition; Malignant Neoplasms; Malignant neoplasm of prostate; Measurement; Mediating; Nurses; Nurses' Health Study; Nutrient; Nutritional; Pathway interactions; Patients; Pattern; Plasma; Progesterone Receptor Status; Questionnaires; Rectal Cancer; Recurrence; Risk; Sample Size; Somatomedins; Survival Rate; Testosterone; Time; Tumor Subtype; Tumor stage; Update; Vegetables; Woman; Work; adiponectin; aged; base; cancer recurrence; cancer risk; cancer site; cohort; cost; design; diet and cancer; follow-up; improved; indexing; malignant breast neoplasm; men; mortality; novel; prospective; receptor; tumor

DESCRIPTION: We propose to expand our current project by prospectively examining the associations between new dietary indexes and dietary patterns and risk of breast, colon, and prostate cancer in cohort studies of 121,700 women aged 30-55 years at baseline (1976, the Nurses' Health Study), 11,686 women aged 24-44 years at baseline (1989, Nurses' Healthy Study II), and 51,529 men aged 40-75 years at baseline (1986, Health Professionals Follow-up Study). Detailed dietary data have been collected through validated semi-quantitative food frequency questionnaires every 2-4 years in each cohort. This competing renewal has four specific aims: 1). We will construct overall, animal, and vegetable low-carbohydrate scores based on intakes of macronutrients and assess their associations with risk of breast cancer (NHS I, II only), colorectal cancer, and prostate cancer (HPFS only). We will consider tumor subtypes/locations as endpoints. 2). We will examine whether adherence to the 2005 Dietary Guidelines for Americans is associated with lower risk of breast, colorectal, and prostate cancers. In addition, we will evaluate the relationship between changes in dietary indices over time and subsequent risk of cancers. The temporal relationship between diet and cancer will be analyzed by using different lag-periods (e.g., 4-12 years). 3). Using a novel statistical approach, Reduced Rank Regression (RRR), we will develop diet patterns that represent the effect of diet on increased insulin resistance (as reflected by increased plasma levels of fasting insulin and C-peptide and decreased adiponectin concentrations), IGF-1 and IGFBP-3, and endogenous sex steroid hormones and examine the relationships between the identified patterns and risk of major cancers. 4). We will examine both pre- and post-diagnostic dietary patterns (including low-carbohydrate scores and the Healthy Eating Index) in relation to survival rates of patients with breast, colon, or prostate cancer. Specifically, we will examine death from any cause, death from the specific cancer, and cancer recurrence, taking into account different tumor stages and treatment. The large size of these cohorts, the prospective design, the repeated and detailed measurements of diet and covariates, the high follow-up rates, and the availability of biochemical measurements provide a unique opportunity to study the relationship between overall diet patterns and risk of the three major cancers and their survivals in an extremely cost-efficient manner. This competing renewal builds on exciting results from the current cycle of our grant and will extend to new cancer sites with tumor subtypes and also address dietary predictors of survival of three major cancers. PUBLIC HEALTH RELEVANCE: The traditional paradigm in epidemiology focuses on cancer risk in relation to a single or a few nutrients or foods. Our currently funded grant has addressed the limitations of traditional nutritional epidemiologic analyses by examining dietary patterns by considering how foods and nutrients are consumed in combinations. In the competing renewal, we propose to examine low carbohydrate diets and adherence to the 2005 Dietary Guidelines for Americans and risk of breast, colorectal, and prostate cancers in three large cohort studies. We will also examine the impact of these dietary patterns on cancer survival. In addition, we will use a novel statistical approach, Reduced Rank Regression (RRR), to develop diet patterns that represent the effect of diet on cancer biomarkers.

描述：我们建议通过前瞻性研究新的饮食指数与饮食模式与乳房，结肠和前列腺癌的风险之间的关联，该研究在121,700名基线时30-55岁的妇女（1976年）（1976年，护士健康研究），11,686名男性研究的妇女（1986年）II，1989年24-44岁的妇女（1989年）（1989年）（1989年），幼儿（1989年），及其健康（1989年），及其护士（1989年），及其护士，及其纽约。基线40 - 75年（1986年，卫生专业人员随访研究）。详细的饮食数据已通过经过验证的半定量食品频率问卷收集每2 - 4年。这种竞争的更新具有四个具体目标：1）。我们将根据大量营养素的摄入量来建立整体，动物和蔬菜低碳水化合物评分，并评估它们与乳腺癌风险（仅NHS I，仅II），结直肠癌和前列腺癌（仅HPFS）的关联。我们将肿瘤亚型/位置视为终点。 2）。我们将研究遵守2005年《美国人饮食指南》是否与乳房，结直肠癌和前列腺癌的风险较低有关。此外，我们将评估饮食指数随着时间的变化与随后的癌症风险之间的关系。饮食与癌症之间的时间关系将通过使用不同的滞后周期（例如4 - 12年）来分析。 3）。 Using a novel statistical approach, Reduced Rank Regression (RRR), we will develop diet patterns that represent the effect of diet on increased insulin resistance (as reflected by increased plasma levels of fasting insulin and C-peptide and decreased adiponectin concentrations), IGF-1 and IGFBP-3, and endogenous sex steroid hormones and examine the relationships between the identified patterns and risk of major cancers. 4）。我们将研究乳腺癌，结肠癌或前列腺癌患者的存活率，研究诊断前和诊断后饮食模式（包括低碳水化合物评分和健康饮食指数）。具体来说，我们将考虑到不同的肿瘤阶段和治疗，从任何原因，特定癌症的死亡以及癌症复发的死亡中进行检查。这些队列的较大尺寸，前瞻性设计，饮食和协变量的重复测量和详细的测量，高跟进率以及生物化学测量的可用性为研究三种主要癌症的整体饮食模式与三种主要癌症的风险与其生存之间的关系提供了独特的机会。这种竞争性的更新是基于我们当前赠款周期的令人兴奋的结果，并将扩展到具有肿瘤亚型的新癌症部位，并解决三种主要癌症生存的饮食预测指标。公共卫生相关性：流行病学的传统范式侧重于与单一或几种营养物质或食物有关的癌症风险。我们目前资助的格兰特通过考虑如何结合食用食物和营养来检查饮食模式，解决了传统营养流行病学分析的局限性。在竞争的更新中，我们建议在三项大型研究中检查低碳水化合物饮食并遵守2005年美国人的饮食指南以及乳房，结直肠癌和前列腺癌的风险。我们还将研究这些饮食模式对癌症生存的影响。此外，我们将使用一种新型的统计方法，减少等级回归（RRR）来开发代表饮食对癌症生物标志物的影响的饮食模式。