Exposure Assessment of Engineered Nanoparticles

工程纳米颗粒的暴露评估

基本信息

批准号：
8062069
负责人：
金额：
$ 26.92万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8062069
关键词：
Address Adverse effects Agreement Artificial nanoparticles Attention Blood Platelets Carbon Carbon Nanotubes Cardiovascular Diseases Chemicals Complement Data Data Collection Electron Microscopy Engineering Environmental Exposure Epidemiology Evaluation Exposure to Goals Hand functions Hazard Assessment Hazard Identification Health Investigation Lung diseases Malignant - descriptor Manufacturer Name Measurement Nanotechnology National Institute of Environmental Health Sciences National Toxicology Program Non-Malignant Occupational Exposure Occupational Medicine Population Production Protocols documentation Research Risk Science Silicon Dioxide Site Site Visit Toxicology Workplace disorder prevention exposed human population flexibility interdisciplinary approach interest multi walled carbon nanotube nano nanofiber nanomaterials nanoparticle particle counter

项目摘要

The health effects from workplace exposure to engineered carbonaceous nanomaterials (e.g., single-walled and multi-walled carbon nanotubes) are uncertain, but may include malignant and non-malignant lung disease and cardiovascular disease. During FY10 the nanotechnology field team completed 5 site visits and emission assessment evaluations using hand held particle counters supplemented by electron microscopy and chemical analysis of the nanomaterials. Facilities evaluated included: 1) Manufacturer/packager of single-walled carbon nanotubes; 2) Research scale production of Multi-walled, carbon nanotube (MWCNT) infused composites. Evaluated emissions during the handling of raw MWCNT¿s as well as machining (cutting, sanding, grinding) of composites containing MWCNT¿s; 3) Manufacturer/packager of single-walled carbon nanotubes; 4) Research scale producer of carbon nanotubes and carbon nanofibers; 5) Manufacturer/packager of nano graphene platelets. Additonal field investigations at sites where engineered nanomaterials are handled and manufactured will be conducted. The focus of these investigations will be on nanomaterials of interest to NTP/NIEHS and NIOSH. Priority will be placed on materials on the OECD list of representative manufactured nanomaterials as well as those that are receiving increased attention due to requests to manufacture, use or distribute in the US.

工作场所接触工程碳纳米材料（例如单壁和多壁碳纳米管）对健康的影响尚不确定，但可能包括恶性和非恶性肺病和心血管疾病。在 2010 财年期间，纳米技术现场团队完成了 5 次实地考察。使用手持式粒子计数器进行排放评估，并辅以电子显微镜和纳米材料的化学分析。设施评估包括： 1) 制造商/包装商。单壁碳纳米管；2) 研究规模生产多壁碳纳米管 (MWCNT) 注入复合材料评估处理原始 MWCNT 过程中的排放量。以及含有 MWCNT 的复合材料的加工（切割、打磨、研磨）¿ s； 3) 单壁碳纳米管的制造商/包装商； 4) 碳纳米管和碳纳米纤维的研究规模生产商； 5) 纳米石墨烯片的制造商/包装商将在处理和制造工程纳米材料的地点进行额外的现场调查。这些调查的重点将放在 NTP/NIEHS 和 NIOSH 感兴趣的纳米材料上。具有代表性的制造纳米材料以及因要求在美国制造、使用或分销而受到越来越多关注的纳米材料清单。