Wingard S06GM07518 (NARCH)

翼加德 S06GM07518 (NARCH)

• 批准号: 8145827
• 金额: $ 11.5万
• 依托单位: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8145827
• 关键词: Acupuncture procedure; Adult; Affect; Aftercare; Age; Amputation; Body mass index; California; Clinic; Clinical; Cohort Studies; Complications of Diabetes Mellitus; Diabetes Mellitus; Diabetic Neuropathies; Diagnosis; Disease; Endothelium; Gender; Hand; Health; Intervention; Intervention Studies; Lasers; Lead; Limb structure; Measures; Microcirculation; Native Americans; Nerve; Neuropathy; Non-Insulin-Dependent Diabetes Mellitus; Numbness; Pain; Patients; Peripheral Nervous System Diseases; Pharmaceutical Preparations; Placebos; Prevalence; Prevalence Study; Procedures; Quality of life; Questionnaires; Randomized; Sampling; Severities; Symptoms; Testing; Time; cost effective; diabetic patient; disability; experience; foot; healthy volunteer; high risk; improved; prevent; study characteristics

TITLE: Acupuncture and Diabetic Neuropathy among Native Americans Native Americans are at high risk for developing type 2 diabetes and a common complication of diabetes, peripheral neuropathy (DPN), The symptoms associated with DPN are typically debilitating, reduce quality of life, and can lead to amputation in the affected limb. Acupuncture has been shown to improve microcirculation measured in healthy volunteers, however this association has not been tested in patients wjth neurovascular disease, in particular those with DPN. In the Prevalence Study, all consecutive patients seen at the Indian Health Council (IHC) Diabetes Clinic over a one year period (approximately 500) will be assessed for clinical peripheral neuropathy, diagnosed using the Neuropathy Disability Score (NDS) and the Neuropathy Symptom Score (NSS). In the Intervention Study. 60 adult diabetic patients with peripheral neuropathy attending the IHC Diabetes Clinic wil) be. randomized to acupuncture treatment or sham acupuncture (placebo), once per week over a 10-week period. Microcirculation/endothelia) activity will be assessed by laser Doppler f luxmetry (LDF) at baseline, immediately after 10 weeks of intervention, and 10 weeks after treatment ends. The standardized Neuropathy Total Symptom Score-6 (NTSS-6) questionnaire will be used to assess symptomatology at the same three points of time. Baseline characteristics of the study cohort (such as age, gender, body mass index, medication use, diabetes severity and control) will be evaluated. It is anticipated that those treated with acupuncture will experience improved microcirculation/endothelial activity as well as fewer symptoms of neuropathy, when compared to those receiving the sham procedure. Nerve damage is a common complication of diabetes that can cause pain and numbness in the hands and feet, and lead to amputations. Acupuncture may be a cost-effective way to treat symptoms of this nerve damage and to prevent more severe complications. In a sample of Native Americans, who are at particularly high risk of diabetes and subsequent nerve damage, acupuncture will be tested as a possible treatment.

标题：美洲原住民的针灸和糖尿病神经病变 美洲原住民患 2 型糖尿病和糖尿病常见并发症周围神经病变 (DPN) 的风险很高。与 DPN 相关的症状通常会导致患者衰弱、降低生活质量，并可能导致患肢截肢。针灸已被证明可以改善健康志愿者的微循环，但这种关联尚未在神经血管疾病患者（尤其是 DPN 患者）中进行测试。在患病率研究中，印度健康委员会 (IHC) 糖尿病诊所一年内连续就诊的所有患者（约 500 名）都将接受临床周围神经病变评估，并使用神经病变残疾评分 (NDS) 和神经病变症状评分进行诊断（国家安全局）。在干预研究中。 60 名患有周围神经病变的成年糖尿病患者将参加 IHC 糖尿病诊所。随机接受针灸治疗或假针灸（安慰剂），每周一次，持续 10 周。将在基线、干预 10 周后以及治疗结束后 10 周立即通过激光多普勒通量测定 (LDF) 评估微循环/内皮细胞活性。标准化神经病总症状评分 6 (NTSS-6) 调查问卷将用于评估同一三个时间点的症状。将评估研究队列的基线特征（例如年龄、性别、体重指数、药物使用、糖尿病严重程度和控制情况）。与接受假手术的患者相比，预计接受针灸治疗的患者的微循环/内皮活性会得到改善，神经病变症状也会减少。神经损伤是糖尿病的常见并发症，可导致手脚疼痛和麻木，并导致截肢。针灸可能是治疗这种神经损伤症状并预防更严重并发症的一种经济有效的方法。在美洲原住民样本中，针灸将作为一种可能的治疗方法进行测试，他们患糖尿病和随后的神经损伤的风险特别高。