Center for Quantitative Electrocardiography and Cardiac Safety

定量心电图和心脏安全中心

基本信息

批准号：
8103999
负责人：
JEAN-PHILIPPE Y COUDERC
金额：
$ 63.16万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-15 至 2013-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8103999
关键词：
Adult Aging American American Heart Association Arrhythmia Cardiac Cardiology Cardiotoxicity Caring Cessation of life Clinical Communities Computers Data Data Storage and Retrieval Defibrillators Development Electrocardiogram Event Fostering Foundations Future Heart Diseases Heart failure Imaging technology Implantable Defibrillators International Internet Investigation Kinetics Lead Maintenance Medical Medical Imaging Medical center Methods Mission Molecular National Heart, Lung, and Blood Institute Patients Pharmaceutical Preparations Pharmacologic Substance Pharmacotherapy Play Population Public Health Reporting Research Research Project Grants Resources Risk Role Safety Secure Signal Transduction Societies Software Tools Stratification Surface Techniques Technology Testing Torsades de Pointes United States Food and Drug Administration Universities Validation college design digital drug testing empowered heart electrical activity heart rhythm improved member mortality novel therapeutics potassium ion prognostic prophylactic scientific organization sudden cardiac death technology validation tool working group

项目摘要

DESCRIPTION (provided by applicant): Cardiac safety remains a major public health concern. Sudden cardiac death (SCD) for instance, is responsible for half of all heart disease deaths and is the largest cause of natural death in the U.S. (representing about 325,000 adults each year). Despite the effort implemented to reduce this number by early advanced care, there is a clear need for the improvement of risk stratification techniques to optimize the use of prophylactic therapies such as implantable defibrillators and drug therapies. Meanwhile cardiac safety is also one of the most challenging hurdles in the development of new molecular entities. It has been estimated that as many as 86% of all drugs tested in pharmaceutical development show specific inhibitory activity of potassium ion kinetics which in some cases can lead to torsades de pointes and potentially to SCD. According to the US Food and Drug Administration (FDA), the main reason for the inability of the current pharmaceutical to effectively screen out potentially harmful drugs is the lack of better markers to improve predictability and efficacy of new compounds. The roles of the surface electrocardiograms (ECGs) as a noninvasive approach to assess drug cardiotoxicity, to predict arrhythmic events, and to risk stratify cardiac and non-cardiac patients represent a matter of paramount importance. We propose to the NHLBI to enable the creation of a "Center for Quantitative Electrocardiography and Cardiac Safety" (CES) by supporting its inceptive activities around 1) the development and maintenance of computer resources (data storage and computing center), 2) the deployment of medical information and 3) the formation of a scientific network. The CES will host the Telemetric and Holter ECG Warehouse, an initiative currently implemented by a working group consisting of staff members from the FDA, the University of Rochester and its Medical Center. The CES will distribute these resources to the International scientific community, sharing unique clinical and ECG information for the design and validation of technologies to improve quantitative electrocardiography and cardiac safety.

描述（由申请人提供）：心脏安全仍然是一个主要的公共卫生问题。例如，心脏猝死（SCD）是所有心脏病死亡的一半，是美国自然死亡的最大原因（每年约为325,000名成年人）。尽管努力通过早期的高级护理来减少这一数字，但显然需要改善风险分层技术，以优化使用预防性疗法（例如可植入的除颤器和药物疗法）。同时，心脏安全也是新分子实体发展中最具挑战性的障碍之一。据估计，在药物开发中测试的所有药物中，多达86％均显示出钾离子动力学的特异性抑制活性，在某些情况下可能导致扭转扭转，并可能导致SCD。根据美国食品和药物管理局（FDA）的说法，当前药物无法有效筛选出潜在有害药物的主要原因是缺乏更好的标记来提高新化合物的可预测性和功效。表面心电图（ECG）作为评估药物心脏毒性，预测心律失常事件以及风险对心脏和非心脏患者进行风险的角色的作用，这是至关重要的问题。我们向NHLBI提议，以建立“定量心电图和心脏安全性中心”（CES）（CES），通过支持其侵入性活动左右1）计算机资源的开发和维护（数据存储和计算中心），2）2）部署医学信息和3）科学网络的形成。 CES将主持遥测和Holter ECG仓库，这是由FDA，Rochester大学及其医疗中心的工作组组成的工作组目前实施的一项计划。 CES将把这些资源分配给国际科学界，共享独特的临床和心电图信息，以设计和验证技术，以改善定量心电图和心脏安全性。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Analysis of T-wave Amplitude Adaptation to Heart Rate Using RR-binning of Long-Term ECG Recordings.

使用长期心电图记录的 RR 合并分析 T 波幅度对心率的适应。

DOI：
发表时间：
2010
期刊：
Computing in cardiology
影响因子：
0
作者：
Johannesen,L;Grove,Usl;Sørensen,Js;Schmidt,M;Graff,C;Couderc,J-P
通讯作者：
Couderc,J-P

Predictive value of beat-to-beat QT variability index across the continuum of left ventricular dysfunction: competing risks of noncardiac or cardiovascular death and sudden or nonsudden cardiac death.

DOI：
10.1161/circep.112.970541
发表时间：
2012-08-01
期刊：
Circulation. Arrhythmia and electrophysiology
影响因子：
0
作者：
Tereshchenko LG;Cygankiewicz I;McNitt S;Vazquez R;Bayes-Genis A;Han L;Sur S;Couderc JP;Berger RD;de Luna AB;Zareba W
通讯作者：
Zareba W

Torsadogenic Drug-induced Increased Short-term Variability of JT-area.

扭转致伤药物引起的 JT 面积短期变异性增加。