A Wearable Electrochemical Alcohol Sensor

可穿戴电化学酒精传感器

• 批准号: 10010893
• 负责人: Yue Huang
• 金额: $ 22.39万
• 依托单位: LABSYS, LLC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-05 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10010893
• 关键词: Alcohol consumption; Alcohols; Artificial skin; Automobiles; Blood; Body Fluids; Cellular Phone; Communication; Data; Detection; Development; Devices; Ear; Electrodes; Electrolytes; Ethanol; Feasibility Studies; Fingers; Goals; Harvest; Health; Human body; Individual; Intercellular Fluid; Intervention; Legal; Liquid substance; Measures; Metals; Microfabrication; Miniaturization; Outcome; Painless; Phase; Prevention; Process; Reaction; Reaction Time; Research; Risk; Safety; Sampling; Scheme; Semiconductors; Sensitivity and Specificity; Silicon; Skin; Structure; Techniques; Technology; Testing; Wireless Technology; adverse outcome; alcohol measurement; alcohol monitoring; analog; biomaterial compatibility; cost; design; detection limit; digital; drinking; improved; innovation; manufacturability; millimeter; miniaturize; minimally invasive; monitoring device; response; sensor; smart watch; social; success; wearable device; wearable sensor technology

Project Summary/Abstract Measuring alcohol consumption is important to individual health and the prevention of adverse consequences of drinking. There are tremendous needs for wearable alcohol continuous sensing devices that are accurate, minimal- or non-invasive, unobstructive and affordable. However, existing technologies cannot provide alcohol sensors with all specifications desired by wearable devices, including size, power, sensitivity, specificity, safety, manufacturability and cost. The proposed project is to develop an alcohol sensor suitable for wearable applications by innovating electrochemical alcohol sensors. The innovation uses microfabrication techniques to achieve high sensitivity, high safety, good manufacturability and low cost with a miniaturized membraneless structure. The catalytic effect of the designed electrolyte-electrode interface achieves high sensitivity and high selectivity. The size of the sensor is less than 2x2 millimeters, can unlock many possibilities for wearable, smartphone, and automobile for alcohol detection in breath, interstitial fluid, or blood. In this project, we aim to demonstrate the technology by an examplary ring form factor wireless powered wearable device that can accurately and continuously monitor the alcohol level in body fluid. In Phase I, in addition to the alcohol sensor, a minimal invasive biocompatible microneedle array is designed to painlessly sample and deliver the interstitial fluid to the sensor. The microneedle array is designed to be processed along with the sensor on the same silicon substrate. The entire process is compatible with the fabrication of complimentary oxde metal semiconductor (CMOS), allowing the further monolithic integration of the microneedle array, the alcohol sensor, and the CMOS sensor readout integrated circuit (IC) in Phase II.

项目概要/摘要 测量酒精消耗量对于个人健康和预防不良反应很重要 饮酒的后果。对可穿戴酒精连续传感的巨大需求 准确、微创或无创、无障碍且价格实惠的设备。然而， 现有技术无法提供具有可穿戴设备所需的所有规格的酒精传感器 设备，包括尺寸、功率、灵敏度、特异性、安全性、可制造性和成本。这 拟议项目是通过创新开发适合可穿戴应用的酒精传感器 电化学酒精传感器。该创新利用微加工技术来实现高 小型化无膜灵敏度高、安全性高、工艺性好、成本低 结构。所设计的电解质-电极界面的催化效果达到了高 灵敏度和高选择性。传感器尺寸小于2x2毫米，可解锁 可穿戴设备、智能手机和汽车用于呼吸酒精检测的多种可能性， 间质液或血液。在这个项目中，我们的目标是通过一个示例来演示该技术 环形无线供电可穿戴设备，可以准确、连续地监测 体液中的酒精含量。在第一阶段，除了酒精传感器之外，还采用了微创技术 生物相容性微针阵列旨在无痛地采样和输送间质液 到传感器。微针阵列设计为与传感器一起进行处理 相同的硅衬底。整个过程与互补的制造兼容 氧化物金属半导体（CMOS），允许微针进一步单片集成 第二阶段的阵列、酒精传感器和 CMOS 传感器读出集成电路 (IC)。