Mentoring and neuroimaging research on new targets for DBS in OCD

强迫症 DBS 新目标的指导和神经影像学研究

基本信息

批准号：
10001008
负责人：
NIKOLAOS MAKRIS
金额：
$ 16.34万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-18 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10001008
关键词：
Affect Aging Anatomy Animals Anterior Appointment Autopsy Award Behavioral Biological Biological Markers Brain Brain Pathology Brain Stem Clinic Clinical Clinical Medicine Clinical Research Clinical Trials Collaborations Complex Corpus striatum structure Data Data Analyses Deep Brain Stimulation Development Diagnosis Diffusion Fiber Foundations Functional disorder Funding General Hospitals Generations Goals Grant Head Hospitals Human Image Implant Individual Investigation Laboratories Lesion Link Lobotomies Macaca mulatta Magnetic Resonance Imaging Maps Massachusetts Measures Medical Mental disorders Mentors Mentorship Metabolic Methods Modernization Monitor Myelin National Institute of Mental Health Nature Neurobiology Neurology Neurosciences Neurosurgical Procedures Obsessive-Compulsive Disorder Operative Surgical Procedures Outcome Parents Patients Pharmaceutical Preparations Play Population Positron-Emission Tomography Postdoctoral Fellow Postoperative Period Probability Prospective Studies Protocols documentation Psychiatrist Psychiatry Radiology Specialty Research Research Personnel Research Support Research Training Residual state Resistance Resolution Rest Retrospective cohort Role Scientist Senior Scientist Shapes Solid Structure Symptoms Talents Testing Thalamic structure Time Tissues Training Translating United States National Institutes of Health Validation Ventral Striatum Woman Work base capsule career career development cingulate cortex cingulotomy connectome electric field experience fluorodeoxyglucose positron emission tomography glucose metabolism graduate student gray matter improved outcome in vivo individual patient medical schools mid-career faculty multimodality neural circuit neuroimaging neuroimaging marker neuroinflammation neuropsychiatric disorder patient oriented programs response skills standard of care success summer student tool tractography treatment strategy undergraduate student white matter white matter change

项目摘要

Abstract I am a clinical psychiatrist by training, and neuroscientist. I have devoted my research career to understanding mechanisms, nature and time-course of intractable psychiatric illnesses, such as obsessive compulsive disorder (OCD). I am an Associate Professor in the Departments of Psychiatry and Neurology at Massachusetts General Hospital (MGH), Harvard Medical School. I serve as Director of the Center for Morphometric Analysis, Department of Psychiatry at MGH, and as Director of Computational Imaging Anatomy at the Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham & Women’s Hospital (BWH), where I hold secondary appointments, at Psychiatry and Radiology, as a research scientist. I have been conducting NIH sponsored research since 2003, when I received my first R03 award. I am currently a PI on two NIH grants (R01, funded by NIA & NIMH; R21 funded by NCCIH) focused on understanding mechanisms of brain development, maturation and aging through a set of neuroimaging tools and their validation in rhesus monkeys. Those two grants together have the potential of delivering validated neuroimaging biomarkers, which could be used to diagnose and monitor neurobiological changes due to myelin loss and neuroinflammation in aging, and a whole list of other neuropsychiatric diseases where those changes are involved. Furthermore, I’m a PI in a new grant (R01MH111917), which specifically focuses on retrospective investigation of imaging- based targeting for DBS in OCD and serves as the scientific basis upon which this K24 application is hoping to extend in depth and scope. Besides my research, I am also involved in mentoring Harvard, MIT and BU undergraduate and graduate students, postdoctoral fellows (including K23 awardees), foreign fellows, and summer students. I am also involved in administrative work, as head of two large laboratories, at MGH and at BWH, and various local and regional committees. Finally, I am getting involved in nonclinical and non-POR research (through my ongoing and pending animal projects), and that takes away from both my mentoring and my POR research. The K24 would protect time and help me to focus on most important for my career development- mentoring (30%), further training and new POR (20%), while devoting remaining 50% to ongoing neuroimaging research in biomarkers of white matter changes in aging and OCD.

抽象的我是一名受过训练的临床恐慌症患者，我的研究生涯致力于理解。顽固性精神疾病（例如强迫症）的机制、性质和时间进程我是精神病学和神经病学系的副教授。我担任哈佛医学院马萨诸塞州总医院 (MGH) 中心主任。麻省总医院精神病学系形态计量分析兼计算成像解剖学主任布莱根妇女医院 (BWH) 精神病学系精神病学神经影像实验室，我曾在精神病学和放射学担任二级职务，担任研究科学家。自 2003 年获得第一个 R03 奖项以来，我一直在进行 NIH 资助的研究，目前我是该项目的 PI。两项 NIH 拨款（R01，由 NIA 和 NIMH 资助；R21 由 NCCIH 资助）专注于理解机制通过一套神经影像工具观察大脑发育、成熟和衰老及其在恒河猴中的验证这两笔资助共同具有验证神经影像生物标志物的潜力，可用于诊断和监测因髓磷脂缺失和神经炎症而引起的神经生物学变化衰老，以及涉及这些变化的一系列其他神经精神疾病。此外，我还参与其中。一项新资助（R01MH111917）的 PI，该资助特别关注成像的回顾性调查基于强迫症 DBS 的目标，并作为 K24 应用程序希望的科学基础除了我的研究之外，我还参与指导哈佛大学、麻省理工学院和波士顿大学。本科生和研究生、博士后研究员（包括 K23 获奖者）、外国研究员和我还担任麻省总医院和麻省总医院两个大型实验室的负责人，参与行政工作。最后，我参与了非临床和非 POR 的工作。研究（通过我正在进行和悬而未决的动物项目），这剥夺了我的指导和我的 POR 研究可以节省时间并帮助我专注于对我职业生涯最重要的事情。发展 - 指导 (30%)、进一步培训和新的 POR (20%)，同时将剩余的 50% 用于持续进行衰老和强迫症白质变化生物标志物的神经影像研究。