Vaccine Production Core

疫苗生产核心

• 批准号: 8294671
• 负责人: Thomas Denny
• 金额: $ 73.16万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8294671
• 关键词: AIDS/HIV problem; Administrator; Clinical Trials; Clinical trial protocol document; Collaborations; Contracts; Cyclic GMP; Development; Dolin; HIV Vaccine Trials Network; Immune response; Immunologic Monitoring; Immunology; Medical; Quality Control; Technology; Testing; TimeLine; United States National Institutes of Health; Vaccine Production; Vaccines; Work; experience; immunogenicity; pre-clinical; preclinical study; product development; programs; quality assurance; success; vaccine development; vector

Critical to the ultimate success of the CHAVI is the development of its capacity to rapidly move new discoveries and acquired technologies to testing in preclinical / clinical trials through collaboration with existing networks such as the HVTN, VRC, CAVD/Enterprise, and the NIH. In Year 3, CHAVI will ask critical questions with the current best vectors and inserts regarding insert immunogenicity and quality of the mucosal and systemic immune responses. The CHAVI Vaccine Production Core will coordinate and manage timelines required for preclinical studies in year 3.

Chavi的最终成功至关重要的是其迅速发展的能力的发展 通过与现有 HVTN，VRC，CAVD/Enterprise和NIH等网络。在第三年，Chavi会问关键问题 具有当前的最佳矢量和有关粘膜免疫原性和质量的插入物以及 系统性免疫反应。 Chavi疫苗生产核心将协调和管理时间表 临床前研究所需的3年级。