Scientific Core: Acquisition, Synthesis, and Characterization of Nanomaterials

科学核心：纳米材料的获取、合成和表征

• 批准号: 8067633
• 负责人: Jeffrey I Zink
• 金额: $ 29.75万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-24 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8067633
• 关键词: Biological; Caliber; Charge; Chemicals; Cobalt; Copper; Data; Encapsulated; Engineering; Equus caballus; Fluorescence; Gatekeeping; Goals; Gold; Hand; In Vitro; Ions; Kilogram; Libraries; Lung; Manufacturer Name; Measurement; Measures; Metals; Methods; Molecular; Outcome; Property; Research; Research Activity; Services; Shapes; Shipping; Ships; Silicon Dioxide; Silver; Structure; Surface; Testing; Titania; Toxic effect; Zinc Oxide; base; cell injury; chemical property; design; fluorescence imaging; fundamental research; in vivo; medical specialties; metal oxide; nano; nanomachine; nanomaterials; nanoparticle; particle; physical property; programs; research study; response; retinal rods

The scientific core is responsible for all of the particles that will be studied in the center. These responsibilities include thorough chemical and physical characterization of all particles, synthesizing new particles for the purposes of completing libraries and for introducing new functionality such as fluorescence, and designing and synthesizing highly specialized particles that will be used to test hypotheses arising from the in vitro and in vivo biological studies about injurious effects at the nano-bio interface. Accurate, thorough and interpretable characterization of Engineered Nanomaterial (ENM) libraries (Table 1) is an absolute necessity for studies of pulmonary toxicity. The physical and chemical properties must be delineated in order to provide a basis for interpreting molecular and cellular injury mechanisms. Manufacturers' statements about the properties of the materials that they ship provide varying degrees of completeness and accuracy. The Scientific Core will carry out all of its own measurements (see section IB) and provide reliable data in a uniform arid interpretable fonnat to the project leaders.

科学核心负责将在中心研究的所有颗粒。这些责任包括所有颗粒的彻底化学和物理表征，合成新颗粒，以完成库以及引入新功能，例如荧光，设计和合成高度专业的颗粒，这些颗粒将用于测试由IntoRO和In Into intro和Vivo生物学在Nano-Bio-Bio-Bio-Bio-Bio-Bio-Bio界面上产生的假设。对工程纳米材料（ENM）文库的准确，透彻和可解释的表征（表1）是研究肺毒性的绝对必要性。必须划定物理和化学特性，以提供解释分子和细胞损伤机制的基础。制造商关于该特性的陈述 他们运送的材料具有不同程度的完整性和准确性。科学核心将进行所有自己的测量结果（请参阅IB节），并在统一的干旱解释中提供可靠的数据为项目负责人。