Administrative Core

行政核心

• 批准号: 8068441
• 负责人: JUNFENG ZHANG
• 金额: $ 16.42万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-28 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8068441
• 关键词: Acute; Address; Advisory Committees; Asthma; Biometry; Carbon; Cellular biology; Characteristics; Collaborations; Computer Simulation; Diesel Exhaust; Disease; Environmental Exposure; Environmental and Occupational Exposure; Exposure to; Funding; Goals; Health; Health Sciences; Human; Immunology; In Vitro; Institutes; Interdisciplinary Study; Journals; Leadership; Left; Liquid substance; London; Lung; Medicine; Modeling; Molecular; National Institute of Environmental Health Sciences; New England; New Jersey; Paper; Persons; Physiological; Play; Property; Publishing; Pulmonology; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Risk; Risk Assessment; Role; Seminal; Silver; Structure; Toxicology; base; college; consumer product; design; in vivo; member; multidisciplinary; nano; nanomaterials; nanotoxicology; organizational structure; particle; research study; respiratory; success

The proposed RESAC Center, entitled Respiratory Effects of Silver and Carbon Nanomaterials, builds on the long-term collaborative relationship between UMDNJ/Rutgers and Imperial College London. This relationship started in 2000-2001 when Dr. Zhang was spending his sabbatical leave at Imperial College. Since then Drs. Zhang and Chung, along with other researchers at UMDNJ and Imperial College, have collaborated on the worid's first study of acute respiratory effects of real-worid exposure to diesel exhaust particles in persons with asthma. This study generated a seminal paper published in New England Journal of Medicine. Drs. Zhang, Chung, and Tetley have continued to collaborate and developed research proposals to further investigate pathophysiological mechanisms underiying cardio-respiratory effects of exposure to diesel exhaust particles and to consumer products containing ENMs, respecfively. (Funding decisions are pending.) The UMDNJ/Rutgers investigators who are part of the RESAC Center proposal are all members of the NlEHS-funded Center for Environmental Exposure and Diseases (CEED) at the Environmental and Occupafional Health Sciences Institute (EOHSI) in New Jersey. The CEED researchers probe scientific questions related to the multidimensional interface between environmental/occupational exposure and human health. This is reflected by the wide range of multidisciplinary expertise (e.g., exposure and risk assessment, PBPK modeling, toxicology, immunology, biostatistics) possessed by the CEED members participafing in the proposed RESAC Center. The UK collaborators provide complimentary expertise (e.g., nano-toxicology, lung and cell biology, pulmonary medicine, nanomaterial synthesis and characterization), enhancing the capability of the RESAC Center to address critical issues called for by the current U19 RFA. The RESAC Center's organizational chart is shown in Figure ACI. The RESAC Center consists of an administrative core, a scientific core, and three research projects. Additionally, the Center has an Integration Committee and a Scientific Advisory Committee. This organizafional structure is designed to encourage, maximize, and facilitate interactions both within and between the research projects, among researchers, and with other centers participating in the NIEHS Consortium established through this RFA. The organizational structure is designed to address, in a highly integrated and synergistic way, the overarching theme of the RESAC Center: the interaction between ENMs and the components of the lung lining fluid. Our Center's approaches involves the use of (1) two model ENMs, nano silver and carbon nanotube, with a large contrast in their physiochemical properties (Scientific Core), (2) a suite of in vitro experiments determining ENM effects and interacfions with the lung lining fluid at the cellular and molecular level (Project 1), (3) a set of in vivo studies to study ENM fate in the lung and physiological effects and underiying mechanisms (project 2), and (4) computational models that can specifically accommodate the unique physicochemical (and consequently toxicological) characteristics of ENMs in the characterization of risk (Project 3).

拟议中的RESAC中心题为《银和碳纳米材料的呼吸作用》，建立在Umdnj/Rutgers与伦敦帝国学院之间的长期合作关系的基础上。这种关系始于2000 - 2001年，当时张博士在帝国大学度过休假。 从那以后Drs。张和钟与Umdnj和帝国学院的其他研究人员一起，合作了Worid的首次研究，该研究对哮喘患者中现实中沃德利德暴露于柴油排气颗粒的急性呼吸作用。这项研究生成了一篇发表在新英格兰杂志的开创性论文 药品。博士。张，钟和泰特利继续合作并制定了研究建议，以进一步研究暴露于柴油排气颗粒的心脏呼吸作用和对含有ENM的消费产品的病理生理机制，并分别对含有ENM的消费产品进行了评估。 （资金决定正在等待。） RESAC中心提案的一部分的UMDNJ/RUTGERS调查人员都是新泽西州环境和占领健康科学研究所（EOHSI）的NLEHS资助的环境暴露与疾病中心（CEED）的成员。 CEED研究人员探究了与环境/职业暴露与人类之间的多维接口有关的科学问题 健康。这反映在广泛的多学科专业知识（例如，接触和风险评估，PBPK建模，毒理学，免疫学，生物统计学）中所拥有的CEED成员参与参与 建议的RESAC中心。英国合作者提供免费的专业知识（例如纳米毒理学，肺和细胞生物学，肺医学，纳米材料合成和表征），增强了RESAC中心解决当前U19 RFA所需的关键问题的能力。 RESAC中心的 组织图如图ACI所示。 RESAC中心由行政核心，科学核心和三个研究项目组成。此外，该中心还有一个集成委员会和科学咨询委员会。这种组织的结构旨在鼓励，最大化和促进研究项目内部和研究人员之间以及与其他参与NIEHS联盟中通过此RFA建立的NIEHS财团的互动。组织结构旨在以高度集成和协同的方式解决RESAC中心的总体主题：ENMS与肺衬里液体的组成部分之间的相互作用。我们中心的方法涉及使用（1）两个模型ENM，纳米银和碳纳米管，其生理化学特性（科学核心）具有很大的对比，（科学核心），（2）一套体外实验的套件，确定ENM效应和与细胞和分子水平的肺部液体的肺部液体（3）（3）的肺部衬里（3）（3）的肺部衬里（3），viv fo and Fo fo and Fo fo and（3）生理效应和不足的机制（项目2）和（4）可以特异性地适应ENM在风险表征中的独特物理化学（并因此是毒理学）特征的计算模型（项目3）。