The Canine as an Animal Model of Human Aging

犬作为人类衰老的动物模型

• 批准号: 8053539
• 负责人: Carl Wayne Cotman
• 金额: $ 66.53万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8053539
• 关键词: Accounting; Acetylation; Aerobic Exercise; Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Amyloid; Animal Model; Animals; Antioxidants; Area; Attenuated; Automobile Driving; Award; Behavioral; Biological Markers; Blood Volume; Brain; Brain Diseases; Brain Pathology; Brain region; Brain-Derived Neurotrophic Factor; Canis familiaris; Caspase; Cells; Cerebrum; Cognition; Cognitive; Complex; Cytosol; Data; Diet; Elderly; Environment; Epigenetic Process; Episodic memory; Event; Exercise; Functional disorder; Funding; Gene Expression; Genes; Goals; Grant; Gray unit of radiation dose; Growth Factor; Health; Hippocampus (Brain); Histone Acetylation; Histones; Human; Impaired cognition; Individual; Instruction; Insulin-Like Growth Factor I; Intervention; Intervention Studies; Learning; Life; Life Style; Link; Long-Term Effects; Magnetic Resonance Imaging; Memory; Memory impairment; Metabotropic Glutamate Receptors; Methylation; Mitochondria; Mitochondrial DNA; Modeling; Molecular; Monitor; N-Methyl-D-Aspartate Receptors; Nerve Degeneration; Neurons; Oxidative Stress; Pathology; Pathway interactions; Pattern; Peptide Hydrolases; Performance; Peripheral; Physical activity; Physiological; Plasma; Prefrontal Cortex; Principal Investigator; Process; Production; Progress Reports; Proteins; Protocols documentation; Relative (related person); Reporting; Reversal Learning; Rodent; Series; Signal Transduction; Surrogate Markers; Synapses; Synaptic plasticity; Testing; Time; Translations; Treatment Efficacy; Validation; activation product; age related; aged; aging brain; brain tissue; calmodulin-dependent protein kinase II; caspase-3; caspase-8; caspase-9; cofactor; cognitive change; cognitive function; combat; dentate gyrus; design; effective intervention; environmental enrichment for laboratory animals; executive function; follow-up; frontal lobe; human data; improved; improved functioning; in vivo; indexing; innovation; insertion/deletion mutation; lifestyle intervention; mitochondrial DNA mutation; mitochondrial dysfunction; mouse model; neurogenesis; neuron loss; neuronal survival; normal aging; oxidative damage; prevent; pro-apoptotic protein; programs; social; success; white matter