FOCUS ISSUE ON HIV AND THE CARDIOMETABOLIC SYNDROME

关注艾滋病毒和心脏代谢综合征

• 批准号: 8168733
• 负责人: TODD CADE
• 金额: $ 1.23万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168733
• 关键词: Adult; Age; Aging; Anti-Retroviral Agents; Antineoplastic Agents; Area; Behavioral; Cardiovascular Diseases; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Chronic; Complex; Computer Retrieval of Information on Scientific Projects Database; Data; Diabetes Mellitus; Drug abuse; Epidemic; Funding; General Population; Genetic; Grant; HIV; HIV-2; Health Services Accessibility; Heart Diseases; Human; Infection; Institution; Journals; Life; Life Style; Low income; Lung diseases; Malignant Neoplasms; Metabolic; Minority; Obesity; Pharmacotherapy; Process; Research; Research Personnel; Resources; Risk; Risk Factors; Source; Stroke; Syndrome; Therapeutic; United States National Institutes of Health; Virus Diseases; Woman; men; multidisciplinary; socioeconomics; virus related cancer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infection with human immunodeficiency virus (HIV), use of highly active antiretroviral drug therapies (HAART), undesirable lifestyle/behavioral choices, genetic background, and other factors all contribute to adverse metabolic and morphometric changes in appreciable numbers of adults and children living with HIV. At least in the developed world, HIV/AIDS has transitioned from certain death to a chronic, manageable condition with the potential for long-term salubrious survival, due to therapeutic advances made over the past 10yrs. But many challenges remain, as outlined by the articles in this volume of the Journal of the CardioMetabolic Syndrome. With longer-term survival, will HIV-infected people succumb to the causes of death that are most common among aging humans in the industrialized world, especially components of the cardiometabolic syndrome (heart disease, stroke, lung disease, diabetes), but at an earlier age? Does HIV-infection and the accompanying chronic proinflammatory processes, impart increased risk for these most common causes of death? Are there HIV-specific risk factors for the cardiometabolic syndrome? Recent observational data indicate that deaths from cardiovascular disease, diabetes, non-HIV-related cancer, and drug abuse may be increasing among HIV-infected people (4-8). In addition, socioeconomic and demographic data from the CDC suggest that low-income, poorly educated, young minority men and women with poor access to health care constitute a disproportionate percentage of people newly infected with HIV (2, 3). Are these not the same groups in the general population that are at greater risk for developing diabetes, obesity, heart disease, and cancer? Likewise, the HIV epidemic is most serious in resource-limited areas of the world. As these regions become more developed and industrialized, we anticipate a "collision of epidemics"; HIV and the cardiometabolic syndrome, and recent analyses support this notion (1). The issues are complex and will require multidisciplinary teams and approaches to resolve.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 感染人类免疫缺陷病毒（HIV），使用高度活跃的抗逆转录病毒药物疗法（HAART），不良的生活方式/行为选择，遗传背景和其他因素，都导致不良代谢和形态计数器，患有艾滋病毒的成人和儿童的不良代谢和形态变化。 至少在发达国家，由于过去10年中的治疗性进步，艾滋病毒/艾滋病已经从某些死亡转变为长期可管理的，有可能出现长期生存的状况。 但是，如《心脏代谢综合征杂志》杂志中的文章所概述的那样，仍然存在许多挑战。 具有长期的生存，将艾滋病毒感染的人屈服于工业化世界中衰老的人类中最常见的死亡原因，尤其是心脏代谢综合征的成分（心脏病，中风，肺部疾病，糖尿病），但在年龄？ 艾滋病毒感染和随附的慢性促炎过程是否会增加对这些最常见的死亡原因的风险？心脏代谢综合征是否有HIV特异性危险因素？最近的观察数据表明，心血管疾病，糖尿病，非HIV相关癌症和药物滥用的死亡可能正在增加HIV感染者（4-8）。 此外，来自CDC的社会经济和人口统计数据表明，获得医疗保健的低收入，受过良好教育的年轻男性和不良的男女占新感染艾滋病毒的人中的比例不成比例（2，3）。 这些在普通人群中与患糖尿病，肥胖，心脏病和癌症的风险更大的群体是否相同？ 同样，艾滋病毒流行病在世界上有限的领域中最严重。 随着这些地区变得越来越发达和工业化，我们预计会有“流行病的碰撞”。 HIV和心脏代谢综合征，最近的分析支持了这一概念（1）。 这些问题很复杂，需要多学科的团队和方法才能解决。