Molecular Genetics and Nutrigenomics

分子遗传学和营养基因组学

• 批准号: 8020197
• 负责人: BRAXTON D MITCHELL
• 金额: $ 26.86万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8020197
• 关键词: Affect; Aging; Area; Basic Science; Bioinformatics; Chronic Disease; Clinical Investigator; Clinical Research; Cloning; Complement; Complementary DNA; DNA; DNA Library; DNA Sequence; DNA Sequence Analysis; DNA analysis; Data; Data Analyses; Disease; Epidemiology; Faculty; Gene Targeting; Genes; Genetic; Genetic Polymorphism; Genetic Services; Genome; Genomics; Genotype; Goals; Haplotypes; High Pressure Liquid Chromatography; Human Resources; Ice; Instruction; Lead; Methods; Molecular; Molecular Biology; Molecular Genetics; Mutation Detection; Nutrient; Obesity; Plasma; Prevention; Process; Productivity; Quality Control; Research Design; Research Personnel; Risk; Services; Site-Directed Mutagenesis; Students; Translating; abstracting; base; common treatment; computerized data processing; cost; data mining; design; epidemiology study; field study; gene environment interaction; genetic epidemiology; genetic linkage analysis; genome wide association study; genome-wide; insight; member; nutrient metabolism; nutrition; trait

Abstract Nutrigenomics is a rapidly emerging field that studies the interface between nutrients and genomics. The study of nutrigenomics attempts to relate the processes affecting nutrient metabolism to particular genes or alternatively, to identify specific genes associated with a nutrition-related endpoint and then assess how its relation to nutrient metabolism. Insights derived from nutrigenomics will form the basis of individualized approaches to nutrition, or 'personalized nutrition.' The purpose of the Molecular Genetics and Nutrigenomics (MGN) Core is to provide services and support for basic science and clinical investigators that will enhance our understanding of the molecular and genetic basis of nutrient metabolism and the risk of chronic disease during aging. Elucidation of the genetic underpinnings of nutrition-related diseases and traits may provide key mechanistic insights that may lead to more effective prevention and treatment for these common diseases. To achieve these goals, the MGN Core will provide services to members of the Mid-Atlantic NORC in molecular genetics, genomics, and genetic epidemiology. Additionally, the Core will provide instruction and technical support to NORC users. The services to be provided by the MGN Core wil be in the areas of: (1) molecular genetics (DNA extraction, genotyping, sequencing, mutation detection); (2) molecular genomics (high through SNP genotyping and data processing); (3) and genetic epidemiology (study design, power calcuations, analysis for linkage and association studies, bioinformatics support for GWAS studies, and data mining). The MGN Core was designed to complement services available in other Cores by providing expertise and support to Center investigators to carry out genetic and genomic studies of obesity and other nutrition-related chronic diseases that can be translated into clinical studies to assess gene by environment interactions with support from the CTR Core, and pursued through basic mechanism studies to assess molecular and cellular level mechanisms with support from the ABBM Core. The extensive use and productivity of the MGN Core in the last five years demonstrates the enrichment it provides to ongoing studies by providing Center investigators with ready access to a wide range of services, promoting cross-disciplinary interactions among Center investigators, and educating students, fellows and junior faculty.

抽象的 营养基因组学是一个快速新兴的领域，研究营养物质和营养物质之间的相互作用 基因组学。营养基因组学的研究试图将影响营养的过程联系起来 代谢到特定基因，或者识别与特定基因相关的特定基因 营养相关终点，然后评估其与营养代谢的关系。见解 来自营养基因组学的成果将构成个体化营养方法的基础，或者 “个性化营养”。 分子遗传学和营养基因组学 (MGN) 核心的目的是提供 为基础科学和临床研究人员提供服务和支持，这将增强我们的能力 了解营养代谢的分子和遗传基础以及慢性病的风险 衰老过程中的疾病。阐明营养相关疾病的遗传基础 特征可能提供关键的机制见解，从而导致更有效的预防和治疗 针对这些常见疾病的治疗。为了实现这些目标，MGN 核心将提供 为中大西洋 NORC 成员提供分子遗传学、基因组学和遗传学服务 流行病学。此外，核心将为 NORC 提供指导和技术支持 用户。 MGN 核心提供的服务将涉及以下领域： (1) 分子遗传学 （DNA提取、基因分型、测序、突变检测）； (2)分子基因组学（高 通过SNP基因分型和数据处理）； (3) 和遗传流行病学（研究设计， 功效计算、连锁和关联研究分析、生物信息学支持 GWAS 研究和数据挖掘）。 MGN 核心旨在通过提供以下功能来补充其他核心中可用的服务： 为中心研究人员开展遗传和基因组研究提供专业知识和支持 肥胖和其他与营养相关的慢性疾病可以转化为临床研究 在 CTR 核心的支持下，通过环境相互作用评估基因，并通过 基本机制研究，以评估分子和细胞水平的机制，并得到以下机构的支持 ABBM 核心。过去五年 MGN Core 的广泛使用和生产力 展示了它为中心研究人员提供的正在进行的研究的丰富性 随时获得广泛的服务，促进跨学科互动 中心研究人员以及学生、研究员和初级教师的教育。