Clinical Core

临床核心

基本信息

批准号：
10017686
负责人：
John Paul Clancy
金额：
$ 24.61万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10017686
关键词：
Atlases Biological Markers Biological Models Biology Biometry Bronchoalveolar Lavage Fluid Bronchoscopy Caring Cells Center Core Grants Clinical Clinical Research Clinical Trials Colorectal Surgery Communities Consultations Coupled Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Data Analyses Emerging Technologies Epithelial Cells Foundations Health Human Image Infant Infrastructure Interdisciplinary Study International Intestines Investigator-Initiated Research Link Liquid substance Lung Lung Transplantation Magnetic Resonance Imaging Measurement Measures Medical center Monitor Mutation National Institute of Diabetes and Digestive and Kidney Diseases Nose Pathology Patients Pediatric Hospitals Physiological Process Pulmonology Research Research Personnel Research Project Grants Research Support Sampling Serum Source Specimen Spirometry Sputum Standardization Structure Structure of respiratory epithelium Therapeutic Studies Time Tissues Translational Research Vision biobank clinical efficacy clinical investigation cystic fibrosis patients design gastrointestinal indexing lung imaging novel programs ranpirnase translational scientist ventilation

项目摘要

PROJECT SUMMARY/ABSTRACT: A key foundational component of this P30 application is the Personalized Clinical Core, which will be the primary source of human cells, tissues, biofluids [e.g.: sputum, bronchoalveolar lavage fluid (BALF), sweat, serum] and translational research expertise. The Personalized Clinical Core builds directly on current clinical research strengths and infrastructure at CCHMC, including the CFF-TDN program, the CF-RDP program, investigator-initiated research, and institutional commitments to CF translational research. The Personalized Clinical Core will expand these capabilities in critical ways, focusing exclusively on obtaining patient-derived biospecimens accompanied by clinical correlates, and providing full clinical research capabilities to operationalize novel translational research projects. The Personalized Clinical Core will coordinate the procurement, expansion, banking, and distribution of human specimens, and provide translational researchers with appropriate clinical research support to execute and interpret clinical investigation. The vision of this P30 Core is to enhance the CF-focused research on campus by provision of well-characterized, high quality and human-only samples from CF patients and appropriate non- CF controls. Centralizing these capabilities through the Personalized Clinical Core structure will help to drive research efficiencies and standardization. In addition, the samples obtained and processed through the Personalized Clinical Core will be available for direct use by CF researchers, and for projects utilizing the Personalized Model Systems Core and the Atlas of the CF Respiratory Epithelial Cells Core.

项目概要/摘要：该 P30 应用程序的一个关键基础组件是个性化临床核心，它将成为人体细胞、组织、生物液体的主要来源[例如：痰、支气管肺泡灌洗液 (BALF)、汗液、血清]和转化研究专业知识。个性化临床核心直接建立在当前 CCHMC 的临床研究优势和基础设施，包括 CFF-TDN 计划、CF-RDP 计划、研究者发起的研究以及机构对 CF 转化研究的承诺。这个性化临床核心将以关键方式扩展这些能力，专注于获得源自患者的生物样本并附有临床相关性，并提供全面的临床研究实施新颖的转化研究项目的能力。个性化临床核心将协调人体标本的采购、扩展、储存和分配，并提供具有适当临床研究支持的转化研究人员来执行和解释临床调查。 P30 核心的愿景是通过提供以下内容来加强校园内以 CF 为重点的研究：来自 CF 患者的特征明确、高质量且仅限人类的样本以及适当的非 CF 控制。通过个性化临床核心结构集中这些能力将有助于推动研究效率和标准化。此外，获得并处理的样品通过个性化临床核心将可供 CF 研究人员直接使用，也可用于利用个性化模型系统核心和 CF 呼吸上皮细胞核心图谱。