Signal Processing And Instrumentation Section

信号处理和仪器部分

基本信息

批准号：
10018389
负责人：
THOMAS J POHIDA
金额：
$ 193.04万
依托单位：
CENTER FOR INFORMATION TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10018389
关键词：
3-Dimensional Adult Automation Behavior Biological Biomedical Research Biophysics Bioreactors Bone Growth Bone Marrow Stem Cell Brain Caenorhabditis elegans Cardiovascular system Cartilage Cell Culture Techniques Cells Cervix Diseases Characteristics Chemicals Clinic Clinical Clinical Research Collaborations Communication Computers Custom Detection Development Devices Diagnosis Disease Disseminated Malignant Neoplasm Documentation Drosophila genus Electroconvulsive Therapy Electron Spin Resonance Spectroscopy Electronics Embryo Engineering Environment Environmental Monitoring Epiphysial cartilage Evaluation Evoked Potentials Eye Fluorescence Fostering Fresh Tissue Gel Generations Genomics Growth HIV-1 Hematopoietic stem cells Histology Histopathology Home environment Human Image Impaired cognition Incubators Individual Infrastructure Institutes Intervention Intramural Research Program Knowledge Laboratories Laboratory Research Learning Light Lighting Localized Malignant Neoplasm Locomotion Lymphoid Machine Learning Magnetic Resonance Imaging Malignant neoplasm of prostate Mechanics Memory Methodology Methods Microdissection Microfabrication Microfluidics Microscopy Mobile Health Application Modeling Molds Molecular Analysis Monitor Motor Mus National Heart, Lung, and Blood Institute National Institute of Allergy and Infectious Disease National Institute of Biomedical Imaging and Bioengineering National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Drug Abuse National Institute of Environmental Health Sciences National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute on Alcohol Abuse and Alcoholism National Institute on Deafness and Other Communication Disorders Near-Infrared Spectroscopy Neurons Neurosciences Optics Organ Oxygen Oxygen saturation measurement Pain Pathology Peritoneum Pharmaceutical Preparations Phase Phenotype Placenta Postdoctoral Fellow Principal Investigator Process Production Prostate Prostatectomy Prostatic Neoplasms Proteins Proteomics Radiochemistry Research Research Personnel Resources Retinal Retinal Dystrophy Robotics Rodent Science Scientist Sensory Signal Transduction Sleep Software Engineering Specimen Spinal Surface System Systems Biology Techniques Technology Testing Time Tissues Training Transurethral Resection United States National Institutes of Health Validation Vibrissae adaptive optics analog analytical ultracentrifugation base bioimaging bone cancer cell cancer imaging cancer therapy cognitive testing collaborative environment data acquisition design digital drug efficacy electric field engineering design experience fluorescence lifetime imaging fly high reward high risk improved in vivo innovation instrument instrumentation intravital microscopy machine vision micromanipulator mimetics molecular diagnostics monitoring device motor disorder multimodality neuroimaging neuronal circuitry next generation novel novel strategies otoacoustic emission portability pre-clinical precision medicine programs prototype radio frequency radiotracer research and development research clinical testing research study response retinal imaging scaffold sensor signal processing software development somatosensory systems research technology development theories tissue culture

项目摘要

The research and development activities of the Signal Processing and Instrumentation Section (SPIS) are collaborative efforts with NIH Institute scientists that require the development of biomedical laboratory and clinical research systems, instrumentation, and methodologies. The majority of these collaborations require novel approaches and designs for which there are minimal established criteria or technical knowledge. SPIS staff have in-depth technical experience in all phases of engineering research and development. With their collaborators, SPIS staff review the clinical and biomedical sciences to formulate project specifications. SPIS staff evaluate the theoretical and practical constraints, consider commercially available technologies, and finally propose various solutions. SPIS responsibilities often continue with the hands-on design, implementation, testing, installation, training, documentation, and production of a custom research system or methodology. Current collaborative projects, as well as associated research studies include: 1. Improved Transurethral Resection Device; NCI. 2. Tissue Culture Matrix Casting for Spheroid Growth and Histology; NCI. 3. Ex Vivo Model Using Human Peritoneum for Primary and Metastatic Cancer of Human Mesothelial Surfaces; NCI. 4. Multimodal Nonlinear Microscopy with Spectral-focusing CARS and Stimulated Emission; NHLBI. 5. Video Acquisition of Mouse Locomotion and Motor Stability when Impacted by Chemogenetic Stimulation; NINDS. 6. Evaluation of a Novel Cognitive Testing Framework for Individuals with Severe Cognitive Impairment; NIMH. 7. Design and Fabrication of Electrospun Scaffolds for the Study of Humanized Bone Models; NCI. 8. Home-cage Mouse Monitoring Device for Learning and Memory; NIDDK. 9. Tissue Microdissection for Molecular Analysis of Disease and Normal States (LCM, TAM, xMD, TAM, fTAM); NICHD, NIDA, NIBIB, NCI, NIMH. 10. Electron Paramagnetic Resonance Imaging of In Vivo Oxygen Status Associated with Cancer Treatment Studies; NCI, NINDS. 11. Video Monitoring System for Automated Detection of Pain Related Mice Behaviors; NIDDK. 12. High-throughput Video-based Assessment of Drosophila - Drug Efficacy & Sleep Studies; NHLBI, NIDDK. 13. Microfluidic Platform for PNA-Based Molecular Diagnostics of HIV-1; NIDDK, NIBIB. 14. Intra-vital Microscopy Using Non-linear Optical Techniques; NHLBI. 15. Video-Based Tracking System for the Routine Clinical Evaluation of Motor Disorders; NIDA, NIA. 16. Electric Field Effects on Cells - Evaluation as Cancer Therapy; NICHD, NIBIB. 17. High-throughput Systems to Evaluate Drug/Chemicals in Adult Flies; NIDDK. 18. Advanced Methods of Whole Mount Sectioning of Prostatectomy Specimens for Imaging, Diagnosis, and Pathology Studies - Correlating In Vivo Prostate MRI and Histopathology using Individualized MR-Based Molds; NCI. 19. Response of Somatosensory Neurons Instrumentation; NCCIH. 20. Multi-characteristic Framework for Prostate Cancer Localization; NCI. 21. Prostate Tumor Fresh Tissue Guided Procurement Methods; NCI. 22. System for Continuous Observation of Rodents in Home-cage Environment (SCORHE) for Phenotyping and Cancer Treatment Evaluation; NCI, NIDDK, NHLBI, NIEHS, FDA. 23. Mouse Homecage Environmental Monitoring with Sensors; NIDDK, OD, FDA, HHS. 24. Quantitative Fluorescence Lifetime Imaging for Disease Detection and Monitoring; NICHD, NCI, NIBIB. 25. Vessel Mimetics for Cancer Cell Culture; NCI, NIBIB. 26. OCT and Adaptive Optics Retinal Imaging with Eye Tracking; NEI. 27. Mouse Illumination System for Retinal Dystrophy Studies; NEI. 28. PRiME - Cardiovascular Intervention; NHLBI, CNMC. 29. Using Light-sheet Microscopy to Understand Evoked Motor Sequence Generation in Drosophila; NIMH. 30. Engineering Retinal Therapies via Bioreactors & 3D Gels; NEI, NIBIB. 31. Analytical Ultracentrifugation for Protein Assembly Dynamics; NIBIB. 32. C. Elegans Embryo Tracking in Temporal SPIM Images; NIBIB. 33. Bone Growth Plate Cartilage Pellet Culture Bioreactor; NICHD. 34. Technologies to Study Rodent Vestibular Sensory Evoked Potentials; NIDCD. 35. Quantitative Characterization of Normal and Disease Cervix Tissue; NICHD, NHLBI. 36. Radiochemistry Laboratory Instrumentation and Automation Enabling Radiotracer Development and Preclinical Neuroimaging Research; NIAAA. 37. Hematopoietic Stem Cell Bone Marrow Bioreactor; NHLBI, NIBIB. 38. Portable Fluorescence Camera System for Offsite Tumor Imaging; NCI, NIBIB. 39. Image-Based Robotic Targeting System to Control Micromanipulators for Living Biological Tissues (Brain/Spinal) Studies; NINDS. 40. Placenta Real-time Oximetry Using Near Infrared Spectroscopy; NICHD. 41. Distortion Product Otoacoustic Emissions System; NIDCD. 42. Mouse Whisker Monitoring for Neuronal Circuit Studies; NIMH. 43. Next Generation Electroconvulsive Therapy System; NIMH. 44. Microfluidics, Microfabrication, and Microanalysis Technologies for Molecular Analysis and Biomedical Research; NIBIB, NIST. 45. Lymphoid Organ 3D Tissue Culture Bioreactor; NIAID.

信号处理和仪器部分 (SPIS) 的研发活动是与 NIH 研究所科学家的合作努力，需要开发生物医学实验室和临床研究系统、仪器和方法。这些合作中的大多数都需要新颖的方法和设计，而这些方法和设计的既定标准或技术知识很少。 SPIS员工在工程研发的各个阶段都拥有深厚的技术经验。 SPIS 工作人员与合作者一起审查临床和生物医学科学，以制定项目规范。 SPIS 工作人员评估理论和实践限制，考虑商用技术，最后提出各种解决方案。 SPIS 的职责通常是亲自设计、实施、测试、安装、培训、文档编制和定制研究系统或方法的生产。目前的合作项目以及相关研究包括： 1.改进的经尿道电切装置；国家癌症研究所。 2. 用于球体生长和组织学的组织培养基质铸造；国家癌症研究所。 3. 使用人腹膜治疗人间皮表面原发性和转移性癌症的离体模型；国家癌症研究所。 4. 具有光谱聚焦CARS和受激发射的多模态非线性显微镜； NHLBI。 5.受化学遗传学刺激影响时小鼠运动和运动稳定性的视频采集； NINDS。 6. 针对严重认知障碍患者的新型认知测试框架的评估； NIMH。 7. 用于人性骨模型研究的静电纺丝支架的设计与制作；国家癌症研究所。 8. 家用笼鼠学习记忆监测装置；尼德克。 9. 用于疾病和正常状态分子分析的组织显微切割（LCM、TAM、xMD、TAM、fTAM）； NICHD、NIDA、NIBIB、NCI、NIMH。 10.与癌症治疗研究相关的体内氧状态的电子顺磁共振成像； NCI、NINDS。 11. 自动检测小鼠疼痛相关行为的视频监控系统；尼德克。 12. 基于视频的高通量果蝇评估——药效和睡眠研究； NHLBI、NIDDK。 13. 基于 PNA 的 HIV-1 分子诊断微流控平台；尼德克，尼比布。 14. 使用非线性光学技术的活体显微镜检查； NHLBI。 15. 用于运动障碍常规临床评估的视频跟踪系统；尼达，尼娅。 16. 电场对细胞的影响——作为癌症治疗的评估； NICHD，NIBIB。 17. 评估成年果蝇药物/化学品的高通量系统；尼德克。 18. 用于成像、诊断和病理学研究的前列腺切除标本整体切片的先进方法 - 使用基于 MR 的个体化模具关联体内前列腺 MRI 和组织病理学；国家癌症研究所。 19. 体感神经元响应仪器； NCCIH。 20. 前列腺癌定位的多特征框架；国家癌症研究所。 21.前列腺肿瘤新鲜组织引导采购方法；国家癌症研究所。 22.用于表型分析和癌症治疗评估的在家笼环境中连续观察啮齿动物的系统（SCORHE）； NCI、NIDDK、NHLBI、NIEHS、FDA。 23. 用传感器进行小鼠笼环境监测； NIDDK、OD、FDA、HHS。 24. 用于疾病检测和监测的定量荧光寿命成像； NICHD、NCI、NIBIB。 25. 用于癌细胞培养的血管模拟物； NCI、NIBIB。 26. OCT 和带有眼动追踪的自适应光学视网膜成像；内伊。 27. 用于视网膜营养不良研究的小鼠照明系统；内伊。 28. PRiME——心血管干预； NHLBI、CNMC。 29. 使用光片显微镜了解果蝇的诱发运动序列生成； NIMH。 30. 通过生物反应器和 3D 凝胶进行工程视网膜治疗； NEI，NIBIB。 31. 蛋白质组装动力学分析超速离心；尼比布。 32. 时间 SPIM 图像中的线虫胚胎追踪；尼比布。 33. 骨生长板软骨颗粒培养生物反应器； NICHD。 34. 研究啮齿动物前庭感觉诱发电位的技术； NIDCD。 35. 正常和患病宫颈组织的定量表征； NICHD、NHLBI。 36. 放射化学实验室仪器和自动化支持放射性示踪剂开发和临床前神经影像研究； NIAAA。 37. 造血干细胞骨髓生物反应器； NHLBI、NIBIB。 38. 用于异地肿瘤成像的便携式荧光摄像系统； NCI、NIBIB。 39. 基于图像的机器人瞄准系统，用于控制活体生物组织（脑/脊髓）研究的微操作器； NINDS。 40. 使用近红外光谱法进行胎盘实时血氧测定； NICHD。 41. 失真产物耳声发射系统； NIDCD。 42. 用于神经元回路研究的小鼠晶须监测； NIMH。 43. 下一代电惊厥治疗系统； NIMH。 44.用于分子分析和生物医学研究的微流体、微加工和微分析技术； NIBIB、NIST。 45. 淋巴器官3D组织培养生物反应器； NIAID。