2010 Biology and Pathobiology of The Cornea

2010 角膜生物学与病理学

• 批准号: 7795339
• 负责人: Shukti Chakravarti
• 金额: $ 3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795339
• 关键词: Affect; Animal Model; Anterior; Area; Biology; Biomechanics; Biomimetics; Blindness; Clinical; Contact Lenses; Cornea; Disease; Equilibrium; Eye; Eyelid structure; Fees; Funding; Gene Delivery; Gene Expression Regulation; Genetic Research; Genomics; Hydration status; Image; Immune response; Infection; Injury; Lacrimal gland structure; Light; Molecular and Cellular Biology; Operative Surgical Procedures; Participant; Play; Postdoctoral Fellow; Property; Proteomics; Quality of life; Research; Research Personnel; Role; Secure; Staging; Students; Time; Tissues; Transgenic Animals; Travel; Vision; angiogenesis; career; conjunctiva; cost; frontier; graduate student; immunoregulation; insight; meetings; meibomian gland; ocular surface; public health relevance; regenerative; skills; stem cell biology; symposium

DESCRIPTION (provided by applicant): Vision plays a huge role in the quality of life, and the ocular surface is instrumental in the appropriate refraction and passage of light for normal vision. The cornea is the "window to the eye" and thus as the outermost barrier is uniquely transparent, avascular, and provides 75% of the refractive power of the eye. Unlike other barrier tissues of the body, the cornea and supporting adnexa (eyelids, conjunctiva, meibomian glands, lacrimal glands) have evolved distinctive mechanisms to maintain transparency and refraction. These functional demands are met by the tears, appropriate tissue hydration, biomechanical strength, barrier properties, immune modulation and restricted angiogenesis. Disease, injury, surgery, contact lens wear and infections may all adversely affect the delicate balance required to maintain corneal functions, leading to haze, opacification and blindness. Corneal and anterior eye research has grown tremendously in recent years, and certain areas have become remarkably sophisticated. The intent of this Gordon Research Conference is to provide a setting for researchers, clinicians, clinical fellows, graduate students and postdoctoral fellows to meet and push forward the frontiers of cornea research. This Gordon Research Conference, the first in this area, will provide a unique opportunity to bring together groups exploring corneal function in the context of broader ocular tissues, using cell and molecular biology, imaging, biomechanics, transgenic animal models, gene delivery, microRNA, proteomics, genomics and regenerative stem cell biology. This is a good time to bring these different groups together to compare notes, to collaborate and gain new insights. This biennial conference will also provide a much needed continuity for students and trainees to gradually develop their skill and gain confidence as they strive to become independent investigators. The sessions will be organized to cover recent advances in cornea and ocular surface research, genetic genomic and proteomic approaches, gene regulation by microRNA, barrier functions and secretion, infections, immune response, surgery, biomimetics, stem cell biology and its applications. The aim of this proposal is to secure partial funding for the conference to cover registration fees and/or travel costs for participants. PUBLIC HEALTH RELEVANCE: This biennial Gordon Research Conference on the Biology and pathobiology of the cornea will make a huge impact on the field by providing a well-known conference setting for investigators with diverse expertise and at different career stages to meet and push the frontiers of cornea research.

描述（由申请人提供）：视觉在生活质量中起着巨大的作用，而眼表具有适当的折射和通过，以实现正常视力。角膜是“通往眼睛的窗户”，因此，由于最外面的屏障是独特的透明，易血管，并提供了眼睛折射率的75％。与人体的其他屏障组织不同，角膜和支撑Adnexa（眼睑，结膜，梅博米亚腺体，泪腺）已经发展出独特的机制，以维持透明度和折射。这些功能需求是通过泪水，适当的组织水合，生物力学强度，屏障特性，免疫调节和受限的血管生成来满足的。疾病，损伤，手术，隐形眼镜磨损和感染可能会对维持角膜功能所需的微妙平衡产生不利影响，从而导致雾霾，痴迷和失明。近年来，角膜和前眼研究的增长巨大，某些地区变得非常复杂。这次戈登研究会议的目的是为研究人员，临床医生，临床研究员，研究生和博士后研究员提供环境，以见面并推动角膜研究的前沿。这次戈登研究会议是该领域的第一次会议，将提供一个独特的机会，可以使用细胞和分子生物学，成像，生物力学，转基因动物模型，基因递送，microRNA，蛋白质组学，蛋白质组学，基因组学和再生干细胞生物学来汇集探索角膜功能的小组。这是将这些不同群体聚集在一起以比较笔记，协作并获得新见解的好时机。这两年一次的会议还将为学生和受训者提供急需的连续性，以逐步发展自己的技能并在努力成为独立调查员时获得信心。这些会议将被组织为涵盖角膜和眼表面研究，遗传基因组和蛋白质组学方法的最新进展，通过microRNA，屏障功能和分泌，感染，免疫反应，手术，仿生学，干细胞生物学及其应用的基因调节。该提案的目的是为会议获得部分资金，以支付参与者的注册费和/或旅行费用。 公共卫生相关性：这次双年展的戈登研究会议会议关于角膜生物学和病理生物学将通过为具有多样专业知识和不同职业阶段的调查人员提供众所周知的会议环境，从而对现场产生巨大影响，以相遇和推动角膜研究的前沿。