Novel Translucent Nanocomposite Biomaterials

新型半透明纳米复合生物材料

基本信息

批准号：
7777906
负责人：
Judit E Puskas
金额：
$ 23.17万
依托单位：
UNIVERSITY OF AKRON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-01 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7777906
关键词：
Address Adopted American Arts Back Benchmarking Binding Biocompatible Biocompatible Materials Breast Cancer Patient Carbon Carbon Black Cell Nucleus Cell Proliferation Collaborations Commit Communities Contracture Coronary Country Data Diagnosis Education Elastomers Engineering Excision Failure Fibrosis Filler Funding Future Gel Generations Goals Grant Group Meetings Health Health Services Research Health Status Health system Hematoma Hemorrhage Immersion Investigative Technique Implant In Vitro Incidence Infection Inflammatory Interdisciplinary Study Internal Breast Prosthesis Journals Learning Legal patent Malignant Neoplasms Mammaplasty Mastectomy Materials Testing Mechanics Medical Medical Device Mentors Methods Mind Modeling Molecular Weight Monitor Montmorillonite Necrosis Ohio Operative Surgical Procedures Optics Outcome Patients Peer Review Performance Pharmaceutical Preparations Polymers Postdoctoral Fellow Process Property Prosthesis Psychological reinforcement Publications Publishing Reaction Reporting Reproducibility Research Research Personnel Rupture Safety Saline Schedule School Teachers Science Scientist Shapes Silicone Elastomers Silicone Gels Societies Solutions Spinal Stents Structure Students Supervision Survival Rate Talents Technology Testing Training Trees United States National Institutes of Health Universities Woman Work Youth base biocompatible polymer biomaterial compatibility biomaterial development calcification career clay college copolymer design effective therapy elastomeric experience graduate student health science research high school improved in vivo isobutylene malignant breast neoplasm meetings melting member middle school nano nanocomposite nanoparticle next generation novel operation outreach outreach program particle programs public health relevance research study response skills styrofoam success symposium teacher vinyltoluene

项目摘要

DESCRIPTION (provided by applicant): This project aims to develop a new class of biocompatible nanocomposite using montmorillonite nano- clay with our proprietary polymer - an arborescent form of poly(isobutylene-b-(p-methylstyrene-co- isobutylene)) block copolymer (arbIB-MS), as an alternative to silicone rubber in a breast implant model. This model was selected because of the wide-spread breast cancer among American women, with one in eight women likely to develop invasive breast cancer. The existing design and material choice of silicone rubber for breast implants are associated with health complications, such as gel bleed and capsular contracture, to require patients to undergo re-operations for correction or implant removal. This situation calls for new materials. Our preliminary results show that the carbon nanocomposite of arbIB-MS mechanical performance and biocompatibility exceeds that of silicone rubber. Blending nano-clay into this polymer can further enhance the overall material performance and retain optical transparency/translucency. In this two-year project, specific aims are set to synthesize arbIB-MS at a lab-batch scale, prepare arbIB-MS-clay nanocomposites, evaluate important properties, such as thermal, physical and mechanical properties, and establish the in vitro biocompatibility of these materials (in collaboration with SUMMA Health System). The research tasks of the project have been designed to train and engage a team of a post-doctoral fellow, a graduate student, an undergraduate student, a local high school teacher with a high school student in biomedical and material science research, under the supervision of Dr. Puskas and our collaborators at SUMMA. The undergraduate students and the high school teacher are involved as an outreach initiative to encourage an early immersion of talented youths in scientific study, and bring "research into our classroom" at the local high school level to instill a positive perspective of science, technology and engineering in the next generations of potential graduate students. The project will be tied in with existing and successful outreach programs such as Polymer in a Backpack, Upward Bound and Educational Talent Search, designed for middle school students. The post- doctoral fellow and graduate student will be challenged to develop and conduct research related to biomedicine. Through informal discussion, regular group meetings, regional or national scientific meetings of the Society for Biomaterials, and journal publications, the team members trained in traditional polymer and material science will be given opportunities to present research findings to the biomedical community. If funded, the proposed project would be the first NIH-funded research in the Department of Polymer Science, the leading polymer program in the nation and widely recognized globally. PUBLIC HEALTH RELEVANCE: This AREA project is to develop novel translucent elastomeric clay nanocomposites and test their biocompatibility in vitro. The College of Polymer Science and Polymer Engineering at the University of Akron is the largest polymer research program in the country, offering unique expertise in biomaterial development. This AREA grant would be the first NIH grant in the Department of Polymer Science, exposing teachers and students to health-related research.

DESCRIPTION (provided by applicant): This project aims to develop a new class of biocompatible nanocomposite using montmorillonite nano- clay with our proprietary polymer - an arborescent form of poly(isobutylene-b-(p-methylstyrene-co- isobutylene)) block copolymer (arbIB-MS), as an alternative to silicone rubber in a breast implant model.之所以选择该模型，是因为美国女性的乳腺癌广泛，其中八分之一的女性可能患有侵入性乳腺癌。现有的设计和物质选择用于乳房植入物的硅胶橡胶与健康并发症（例如凝胶出血和囊膜染色）有关，要求患者进行重新操作以进行矫正或去除植入物。这种情况需要新材料。我们的初步结果表明，Arbib-MS机械性能和生物相容性的碳纳米复合材料超过了硅橡胶的碳纳米复合材料。将纳米粘膜混合到该聚合物中可以进一步提高整体材料性能并保留光学透明度/透明度。在这个为期两年的项目中，特定的目标设置为以实验室量表合成ARBIB-MS，准备Arbib-MS-Clay纳米复合材料，评估重要特性，例如热，物理和机械性能，并建立这些材料的体外生物相容性（与Summa Health Sealth System合作）。该项目的研究任务旨在在Puskas博士和我们在Summa的合作者的指导下，旨在培训并与一名博士后研究员，一名研究生，一名本科生，一名来自生物医学和材料科学研究的高中生的当地高中生培训并与一名当地高中生的高中生一起培训和参与。本科生和高中老师参与了一项宣传计划，以鼓励早期沉浸在科学研究中，并在当地的高中一级将“研究进入我们的课堂”，以灌输下一代潜在研究生的科学，技术和工程的积极观点。该项目将与现有和成功的外展计划有关，例如在背包，向上绑定和教育的人才搜索中，该计划是为中学生设计的。博士后研究生和研究生将受到挑战，以开发和进行与生物医学有关的研究。通过非正式讨论，生物材料协会的定期小组会议，区域或国家科学会议以及期刊出版物，接受传统聚合物和材料科学培训的团队成员将有机会向生物医学界呈现研究发现。如果获得资助，则拟议的项目将是美国NIH资助的第一项由美国领先的聚合物计划，全球广泛认可的NIH资助的研究。公共卫生相关性：该地区项目是开发新型半透明的弹性粘土纳米复合材料并在体外测试其生物相容性。阿克伦大学聚合物科学与聚合物工程学院是该国最大的聚合物研究计划，在生物材料开发方面提供了独特的专业知识。该领域的赠款将是聚合物科学系的第一笔NIH赠款，使教师和学生接受与健康相关的研究。